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de Jong, A.J. (author), Klein-Wietinga, I.R. (author), Andersen, S.N. (author), Kwekkeboom, J.C. (author), Herb-van Toorn, L. (author), de Lange-Brokaar, B.J.E. (author), van Delft, D. (author), Garcia, J. (author), Wei, W. (author), van der Heide, H.J.L. (author), Bastiaanen-Jenniskens, Y.M. (author), van Osch, G.J.V.M. (author), Zuurmond, A.M. (author), Stojanovic-Susulic, V. (author), Nelissen, R.G. (author), Toes, R.E.M. (author), Kloppenburg, M. (author), Ioan-Facsinay, A. (author)Background. Obesity is associated with the development and progression of osteoarthritis (OA). Although the infrapatellar fat pad (IFP) could be involved in this association, due to its intracapsular localization in the knee joint, there is currently little known about the effect of obesity on the IFP. Therefore, we investigated cellular and...article 2017
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Klein-Wieringa, I.R. (author), de Lange-Brokaar, B.J. (author), Yusuf, E. (author), Andersen, S.N. (author), Kwekkeboom, J.C. (author), Kroon, H.M. (author), van Osch, G.J. (author), Zuurmond, A.M. (author), Stojanovic-Susulic, V. (author), Nelissen, R.G. (author), Toes, R.E. (author), Kloppenburg, M. (author), Ioan-Facsinay, A. (author)Objective: To get a better understanding of inflammatory pathways active in the osteoarthritic (OA) joint, we characterized and compared inflammatory cells in the synovium and the infrapatellar fat pad (IFP) of patients with knee OA. Methods: Infiltrating immune cells were characterized by flow cytometry in 76 patients with knee OA (mean age 63...article 2016
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Klein-Wieringa, I.R. (author), Andersen, S.N. (author), Kwekkeboom, J.C. (author), Giera, M. (author), de Lange-Brokaar, B.J. (author), van Osch, G.J. (author), Zuurmond, A.M. (author), Stojanovic-Susulic, V. (author), Nelissen, R.G. (author), Pijl, H. (author), Huizinga, T.W. (author), Kloppenburg, M. (author), Toes, R.E. (author), Ioan-Facsinay, A. (author)Previous studies have shown accumulation and an enhanced proinflammatory profile of macrophages in adipose tissue of obese mice, indicating the presence of an interaction between adipocytes and macrophages in this tissue. However, the consequences of this interaction in humans are yet incompletely understood. In this study, we explored the...article 2013
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Klein-Wieringa, I.R. (author), Kloppenburg, M. (author), Bastiaansen-Jenniskens, Y.M. (author), Yusuf, E. (author), Kwekkeboom, J.C. (author), El-Bannoudi, H. (author), Nelissen, R.G.H.H. (author), Zuurmond, A. (author), Stojanovic-Susulic, V. (author), van Osch, G.J.V.M. (author), Toes, R.E.M. (author), Ioan-Facsinay, A. (author)Objectives: Obesity is a risk factor for the development of osteoarthritis (OA) in hands and knees. Adipose tissue can secrete different adipokines with powerful immunomodulatory effects. The infrapatellar fat pad (IFP) is an intra-articular organ in the vicinity of the synovium and cartilage. It is hypothesised that IFP-derived soluble factors...article 2011