Searched for: author:"Kulig, B.M."
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McKee, R.H. (author), Lammers, J.H.C.M. (author), Muijser, H. (author), Owen, D.E. (author), Kulig, B.M. (author), TNO Kwaliteit van Leven (author)
This article reports the results of neurobehavioral tests on representative aromatic constituents, specifically C<sub>9</sub> to C<sub>11</sub> species. The testing evaluated effects in several domains including clinical effects, motor activity, functional observations, and visual discrimination performance. Exposures ranging from 600 to 5000 mg...
article 2010
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Hissink, A.M. (author), Kulig, B.M. (author), Kruse, J. (author), Freidig, A.P. (author), Verwei, M. (author), Muijser, H. (author), Lammers, J.H.C.M. (author), Mckee, R.H. (author), Owen, D.E. (author), Sweeney, L.M. (author), Salmon, F. (author), TNO Kwaliteit van Leven (author)
This report describes a physiologically based pharmacokinetic model for cyclohexane and its use in comparing internal doses in rats and volunteers following inhalation exposures. Parameters describing saturable metabolism of cyclohexane are measured in rats and used along with experimentally determined partition coefficients. The model is...
article 2009
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Lammers, J.H.C.M. (author), Emmen, H.H. (author), Muijser, H. (author), Hoogendijk, E.M.G. (author), McKee, R.H. (author), Owen, D.E. (author), Kulig, B.M. (author), TNO Kwaliteit van Leven (author)
The neurobehavioral effects of inhaled cyclohexane in rats and humans are investigated to define relationships between internal doses and acute central nervous system effects. Rats are exposed for 3 consecutive days at target concentrations of 0, 1.4, 8, and 28 g/m3, 8 h/d. Measurements include standardized observational measures, spontaneous...
article 2009
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Hissink, A.M. (author), Kr├╝se, J. (author), Kulig, B.M. (author), Verwei, M. (author), Muijser, H. (author), Salmon, F. (author), Leenheers, L.H. (author), Owen, D.E. (author), Lammers, J.H.C.M. (author), Freidig, A.P. (author), McKee, R.H. (author), TNO Kwaliteit van Leven (author)
As part of a project designed to develop a framework for extrapolating acute central nervous system (CNS) effects of hydrocarbon solvents in animals to humans, experimental studies were conducted in rats and human volunteers in which acute CNS effects were measured and toxicokinetic data were collected. A complex hydrocarbon solvent, white...
article 2007
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Lammers, J.H.C.M. (author), Emmen, H.H. (author), Muijser, H. (author), Hoogendijk, E.M.G. (author), McKee, R.H. (author), Owen, D.E. (author), Kulig, B.M. (author), TNO Kwaliteit van Leven (author)
To evaluate the neurobehavioral effects of hydrocarbon solvents and to establish a working model for extrapolating animal test data to humans, studies were conducted which involved inhalation exposure of rats and humans to white spirit (WS). The specific objectives of these studies were to evaluate the behavioral effects of exposure to WS in...
article 2007
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McKee, R.H. (author), Lammers, J.H.C.M. (author), Hoogendijk, E.M.G. (author), Emmen, H.H. (author), Muijser, H. (author), Barsotti, D.A. (author), Owen, D.E. (author), Kulig, B.M. (author), TNO Kwaliteit van Leven (author)
As a preliminary step to evaluating the acute neurobehavioral effects of hydrocarbon solvents and to establish a working model for extrapolating animal test data to humans, joint neurobehavioral/toxicokinetic studies were conducted which involved administering ethanol to rats and volunteers. The specific objectives of the present studies were to...
article 2006
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Cappaert, N.L.M. (author), Klis, S.F.L. (author), Muijser, H. (author), Kulig, B.M. (author), Ravensberg, L.C. (author), Smoorenburg, G.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The present study was designed to compare the ototoxic effects of volatile ethyl benzene in guinea pigs and rats. Rats showed deteriorated auditory thresholds in the mid-frequency range, based on electrocochleography, after 550-ppm ethyl benzene (8 h/day, 5 days). Outer hair cell (OHC) loss was found in the corresponding cochlear regions. In...
article 2002
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Cappaert, N.L.M. (author), Klis, S.F.L. (author), Muijser, H. (author), Kulig, B.M. (author), Smoorenburg, G.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The effects on hearing of simultaneous exposure to the ototoxic organic solvent ethyl benzene and broad-band noise were evaluated in rats. The effects of three ethyl benzene concentrations (0, 300 or 400 ppm) and three noise levels (95 or 105 dBlin SPL or background noise at 65 dBlin SPL) and all their combinations were investigated for a 5 day...
article 2001
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de Groot, D.M.G. (author), Bierman, E.P.B. (author), Bruijnzeel, P.L.B. (author), Carpentier, P. (author), Kulig, B.M. (author), Lallement, G. (author), Melchers, B.P.C. (author), Philippens, I.H.C.H.M. (author), van Huygevoort, A.H.B.M. (author)
Poisoning with the potent nerve agent soman produces a cascade of central nervous system (CNS) effects characterized by severe convulsions and eventually death. In animals that survive a soman intoxication, lesions in the amygdala, piriform cortex, hippocampus and thalamus can be observed. In order to examine the mechanisms involved in the...
article 2001
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Muijser, H. (author), Lammers, J.H.C.M. (author), Kulig, B.M. (author)
article 2000
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Cappaert, N.L.M. (author), Klis, S.F.L. (author), Muijser, H. (author), de Groot, J.C.M.J. (author), Kulig, B.M. (author), Smoorenburg, G.F. (author)
article 1999
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Cappaert, N.L.M. (author), Klis, S.F.L. (author), Muijser, H. (author), de Groot, J.C.M.J. (author), Kulig, B.M. (author), Smoorenburg, G.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Exposure to organic solvents has been shown to be ototoxic in animals and there is evidence that these solvents can induce hearing loss in humans. In this study, the effects of inhalation of the possibly ototoxic solvent ethyl benzene on the cochlear function and morphology were evaluated using three complementary techniques: (1) reflex...
article 1999
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Moser, V.C. (author), Tilson, H.A. (author), Macphail, R.C. (author), Becking, G.C. (author), Cuomo, V. (author), Frantik, E. (author), Kulig, B.M. (author), Winneke, G. (author), Instituut CIVO-Toxicologie en Voeding TNO TNO Voeding (author)
article 1997
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Macphail, R.C. (author), Tilson, H.A. (author), Moser, V.C. (author), Becking, G.C. (author), Cuomo, V. (author), Frantik, E. (author), Kulig, B.M. (author), Winneke, G. (author), Instituut CIVO-Toxicologie en Voeding TNO TNO Voeding (author)
article 1997
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Ruwaard, D. (author), Kramers, P.G.N. (author), van Herten, L.M. (author), Bloemhoff, A. (author), Boshuizen, H.C. (author), Perenboom, R.J.M. (author), Hirasing, R.A. (author), van Deursen, C.G.L. (author), Buitendijk, S.E. (author), Emmen, H.H. (author), Kalsbeek, H. (author), Gevers Leuven, J.A. (author), Princen, J.M.G. (author), Verloove-Vanhorick, S.P. (author), Riedstra, M. (author), Passchier-Vermeer, W. (author), van der Pal-de Bruin, K.M. (author), Stafleu, A. (author), den Ouden, A.L. (author), Smulders, P.G.W. (author), Miedema, H.M.E. (author), Schaapveld, K. (author), Lowik, M.R.H. (author), Kulig, B.M. (author), Havekes, L.M. (author)
In 1993 werd voor het eerst een toekomstverkenning gepubliceerd. In dat document werd een groot aantal gezondheidsgegevens over de Nederlandse bevolking in onderlinge samenhang gepresenteerd. Vier jaar later blijkt behoefte aan bijstelling van de cijfers over ziekte, gezondheid en hun oorzaken. Naast die actualisering van gegevens wordt in dit...
book 1997
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Moser, V.C. (author), Becking, G.C. (author), Cuomo, V. (author), Frantik, E. (author), Kulig, B.M. (author), Macphail, R.C. (author), Tilson, H.A. (author), Winneke, G. (author), Brightwell, W.S. (author), de Salvia, M.A. (author), Gill, M.W. (author), Haggerty, G.C. (author), Hornychova, M. (author), Lammers, J. (author), Larsen, J.J. (author), Mcdaniel, K.L. (author), Nelson, B.K. (author), Ostergaard, G. (author), Instituut CIVO-Toxicologie en Voeding TNO TNO Voeding (author)
article 1997
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Moser, V.C. (author), Becking, G.C. (author), Cuomo, V. (author), Frantik, E. (author), Kulig, B.M. (author), Macphail, R.C. (author), Tilson, H.A. (author), Winneke, G. (author), Brightwell, W.S. (author), Cagiano, R. (author), Gill, M.W. (author), Haggerty, G.C. (author), Hornychova, M. (author), Lammers, J. (author), Larsen, J.J. (author), Mcdaniel, K.L. (author), Nelson, B.K. (author), Ostergaard, G. (author), Instituut CIVO-Toxicologie en Voeding TNO TNO Voeding (author)
article 1997
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Moser, V.C. (author), Becking, G.C. (author), Cuomo, V. (author), Frantik, E. (author), Kulig, B.M. (author), Macphail, R.C. (author), Tilson, H.A. (author), Winneke, G. (author), Brightwell, W.S. (author), de Salvia, M.A. (author), Gill, M.W. (author), Haggerty, G.C. (author), Hornychova, M. (author), Lammers, J. (author), Larsen, J.J. (author), Mcdaniel, K.L. (author), Nelson, B.K. (author), Ostergaard, G. (author), Instituut CIVO-Toxicologie en Voeding TNO TNO Voeding (author)
article 1997
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Tilson, H.A. (author), Macphail, R.C. (author), Moser, V.C. (author), Becking, G.C. (author), Cuomo, V. (author), Frantik, E. (author), Kulig, B.M. (author), Winneke, G. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)
article 1997
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van den Berg, K.J. (author), Lammers, J.H.C.M. (author), Hoogendijk, E.M.G. (author), Kulig, B.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Adult male WAG/Rij/MBL rats were dosed with lead acetate at 0, 4.0, 8.0 or 12.5 mg/kg, 5 days per week for 4 weeks. Animals were assessed prior to exposure, at the end of the 4-week exposure period and after a 2-week recovery period using a functional observational battery (FOB) and motor activity assessment. Rats were sacrificed two weeks after...
article 1996
Searched for: author:"Kulig, B.M."
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