Searched for: author:"Kuipers, F."
(1 - 20 of 37)

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Smeltink, E. (author), Herrebout, F. (author), van Bussel, H. (author), Nooren, P. (author), Heijnen, P. (author), Wijngaard, P. (author), Wilkens, J. (author), Kuipers, F. (author), Heemstra de Groot, S. (author), Smolders, B. (author), Heijenk, G. (author), van den Berg, H. (author), Zaalberg, J. (author)
Communicatienetwerken zijn van essentieel belang voor Nederland en de Nederlanders. Iedere dag vertrouwen burgers en bedrijven in Nederland op digitale communicatienetwerken om te werken, te leren, te ontspannen en elkaar op de hoogte te houden. Netwerken zorgen voor innovatie en economische groei in alle sectoren: van zorg en energie tot...
report 2021
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Turkovic, B. (author), Kuipers, F. (author), van Adrichem, N.L.M. (author), Langendoen, K. (author)
Along with exciting visions for 5G communications and the Tactile Internet, the networking requirement of attaining extremely low end-to-end latency has appeared. While network devices are typically equipped with buffers to counteract packet loss caused by short-lived traffic bursts, the more those buffers get filled, the more delay is added to...
conference paper 2018
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van Manthena, M.P.V. (author), Adrichem, N.L.M. (author), van den Broek, C. (author), Kuipers, F. (author)
Network-as-a-Service (NaaS) is a cloud-based service model that offers on-demand network connectivity and the provisioning and management of network services. However, the actual orchestration of dynamically allocating underlying resources to customer requirements is not trivial. In this paper, we propose an SDN-based approach to support the...
conference paper 2015
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Gautier, T. (author), de Haan, W. (author), Grober, J. (author), Ye, D. (author), Bahr, M.J. (author), Claudel, T. (author), Nijstad, N. (author), van Berkel, T.J. (author), Havekes, L.M. (author), Manns, M.P. (author), Willems, S.M. (author), Hogendoorn, P.C. (author), Lagrost, L. (author), Kuipers, F. (author), van Eck, M. (author), Rensen, P.C. (author), Tietge, U.J. (author)
Cholesteryl ester transfer protein (CETP) activity results in a proatherogenic lipoprotein profi le. In cholestatic conditions, farnesoid X receptor (FXR) signaling by bile acids (BA) is activated and plasma HDL cholesterol (HDL-C) levels are low. This study tested the hypothesis that FXR-mediated induction of CETP contributes to this phenotype....
article 2013
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Berbée, J.F.P. (author), Abildayeva, K. (author), Blokland, A. (author), Jansen, P.J. (author), Lütjohann, D. (author), Gautier, T. (author), Sijbrands, E. (author), Prickaerts, J. (author), Hadfoune, M. (author), Ramaekers, F.C.S. (author), Kuipers, F. (author), Rensen, P.C.N. (author)
The e4 allele of apolipoprotein E (APOE4), which is a well established genetic risk factor for development of Alzheimer's disease (AD), is in genetic disequilibrium with the H2 allele of apolipoprotein C1 (APOC1), giving rise to increased expression of apoC-I. This raises the possibility that the H2 allele of APOC1, either alone or in...
article 2011
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Lu, Y. (author), Kuipers, F. (author), den Hartog, F.T.H. (author), van Mieghem, P. (author)
We develop a performance model for the availability of a MobileTV service in a caching hierarchy network. The probability that bandwidth for the service is available is calculated as a function of channel popularity, the number of available channels, cache sizes, network configuration, and content viewing behavior. The system performance and the...
conference paper 2011
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Kuipers, F. (author), Kooij, R.E. (author), de Vleeschauwer, D. (author), Brunnström, K. (author), TNO Informatie- en Communicatietechnologie (author)
Quality of Experience (QoE) relates to how users perceive the quality of an application. To capture such a subjective measure, either by subjective tests or via objective tools, is an art on its own. Given the importance of measuring users' satisfaction to service providers, research on QoE took flight in recent years. In this paper we present...
conference paper 2010
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Lu, Y. (author), Kuipers, F. (author), Janic, M. (author), van Mieghem, P. (author), TNO Informatie- en Communicatietechnologie (author)
Increased Internet speeds together with new possibilities for tailor-made television services have spurred the interest in providing television via the Internet. Several television services are readily available and both IP-layer and application-layer (P2P) technologies are used. When disregarding commercial influences, customers will choose for...
bookPart 2008
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Fallica, B. (author), Lu, Y. (author), Kuipers, F. (author), Kooij, R.E. (author), van Mieghem, P. (author), TNO Informatie- en Communicatietechnologie (author)
Peer-to-Peer (P2P) file sharing has become immensely popular in the Internet. Recently, there has been a growing interest in academic and commercial environments for live streaming using P2P technology. A number of new P2P digital television (P2PTV) applications have emerged. Such P2PTV applications are developed with proprietary technologies...
conference paper 2008
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TNO Kwaliteit van Leven (author), Abildayeva, K. (author), Berbée, J.F.P. (author), Blokland, A. (author), Jansen, P.J. (author), Hoek, F.J. (author), Meijer, O. (author), Lütjohann, D. (author), Gautier, T. (author), Pillot, T. (author), Vente, J.de (author), Havekes, L.M. (author), Ramaekers, F.C.S. (author), Kuipers, F. (author), Rensen, P.C.N. (author), Mulder, M. (author)
The H2 allele of APOC1, giving rise to increased gene expression of apolipoprotein C-I (apoC-I), is in genetic disequilibrium with the APOE4 allele and may provide a major risk factor for Alzheimer's disease (AD). We found that apoC-I protein is present in astrocytes and endothelial cells within hippocampal regions in both human control and AD...
article 2008
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TNO Kwaliteit van Leven (author), Gautier, T. (author), Tietge, U.J.F. (author), Boverhof, R. (author), Perton, F.G. (author), Le Guern, N. (author), Masson, D. (author), Rensen, P.C.N. (author), Havekes, L.M. (author), Lagrost, L. (author), Kuipers, F. (author)
The impact of apolipoprotein C-I (apoC-I) deficiency on hepatic lipid metabolism was addressed in mice in the presence or the absence of cholesteryl ester transfer protein (CETP). In addition to the expected moderate reduction in plasma cholesterol levels, apoCIKO mice showed significant increases in the hepatic content of cholesteryl esters (...
article 2007
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Korsheninnikova, E. (author), van der Zon, G.C.M. (author), Voshol, P.J. (author), Janssen, G.M. (author), Havekes, L.M. (author), Grefhorst, A. (author), Kuipers, F. (author), Reijngoud, D.-J. (author), Romijn, J.A. (author), Ouwens, D.M. (author), Maassen, J.A. (author), TNO Kwaliteit van Leven (author)
Aims/hypothesis: Activation of nutrient sensing through mammalian target of rapamycin (mTOR) has been linked to the pathogenesis of insulin resistance. We examined activation of mTOR-signalling in relation to insulin resistance and hepatic steatosis in mice. Materials and methods: Chronic hepatic steatosis and hepatic insulin resistance were...
article 2006
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den Boer, M.A.M. (author), Berbée, J.F.P. (author), Reiss, P. (author), van der Valk, M. (author), Voshol, P.J. (author), Kuipers, F. (author), Havekes, L.M. (author), Rensen, P.C.N. (author), Romijn, J.A. (author), Gaubius Instituut TNO (author)
Objective - The use of the HIV protease inhibitor ritonavir (RTV) is frequently associated with hypertriglyceridemia and lipodystrophy. The aim of our study was to determine the mechanism underlying the observed hypertriglyceridemia. Methods and Results - Feeding female APOE*3-Leiden transgenic mice a Western-type diet supplemented with RTV (35...
article 2006
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den Boer, M.A.M. (author), Voshol, P.J. (author), Schröder-van Der Elst, J.P. (author), Korsheninnikova, E. (author), Ouwens, D.M. (author), Kuipers, F. (author), Havekes, L.M. (author), Romijn, J.A. (author), TNO Kwaliteit van Leven (author)
Several studies have demonstrated an association in humans between plasma levels or production capacity of the antiinflammatory cytokine IL-10 and insulin sensitivity. The aim of our study was to investigate the protective role of endogenous IL-10 availability in the development of diet-induced insulin resistance. We compared parameters of...
article 2006
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den Boer, M.A.M. (author), Voshol, P.J. (author), Kuipers, F. (author), Romijn, J.A. (author), Havekes, L.M. (author), TNO Kwaliteit van Leven (author)
Insulin is an important inhibitor of both hepatic glucose output and hepatic VLDL-triglyceride (VLDL-TG) production. We investigated whether both processes are equally sensitive to insulin-mediated inhibition. To test this, we used euglycemic clamp studies with four increasing plasma concentrations of insulin in wild-type C57Bl/6 mice. By...
article 2006
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Delsing, D.J.M. (author), Post, S.M. (author), Groenendijk, M. (author), Solaas, K. (author), van der Boom, H. (author), van Duyvenvoorde, W. (author), de Wit, E.C.M. (author), Bloks, V.W. (author), Kuipers, F. (author), Havekes, L.M. (author), Princen, H.M.G. (author), TNO Kwaliteit van Leven (author)
The present study was designed to investigate the lipid-lowering properties and mechanisms of action of a new HMG-CoA reductase inhibitor, rosuvastatin, in female ApoE*3-Leiden transgenic mice. Mice received a high fat/cholesterol (HFC) diet containing either rosuvastatin (O [control], 0.00125%, 0.0025%, or 0.005% [w/w]) or 0.05% (w/w)...
article 2005
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Hulzebos, C.V. (author), Voshol, P.J. (author), Wolters, H. (author), Kruit, J.K. (author), Ottenhof, R. (author), Groen, A.K. (author), Stellaard, F. (author), Verkade, H.J. (author), Kuipers, F. (author), TNO Preventie en Gezondheid (author)
Background/Aims: Bile flow consists of bile salt-dependent bile flow (BSDF), generated by canalicular secretion of bile salts, and bile salt-independent flow (BSIF), probably of combined canalicular and ductular origin. Bile salt transport proteins have been identified in cholangiocytes, suggesting a role in control of BSDF and/or in control of...
article 2005
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TNO Kwaliteit van Leven (author), Grefhorst, A. (author), Hoekstra, J. (author), Derks, T.G.J. (author), Ouwens, D.M. (author), Baller, J.F.W. (author), Havinga, R. (author), Havekes, L.M. (author), Romijn, J.A. (author), Kuipers, F. (author)
Accumulation of triglycerides (TG) in the liver is generally associated with hepatic insulin resistance. We questioned whether acute hepatic steatosis induced by pharmacological blockade of β-oxidation affects hepatic insulin sensitivity, i.e., insulin-mediated suppression of VLDL production and insulin-induced activation of phosphatidylinositol...
article 2005
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TNO Kwaliteit van Leven (author), Grefhorst, A. (author), van Dijk, T.H. (author), Hammer, A. (author), van der Sluijs, F.H. (author), Havinga, R. (author), Havekes, L.M. (author), Romijn, J.A. (author), Groot, P.H. (author), Reijngoud, D.J. (author), Kuipers, F. (author)
Liver X receptor (LXR) agonists have been proposed to act as anti-diabetic drugs. However, pharmacological LXR activation leads to severe hepatic steatosis, a condition usually associated with insulin resistance and type 2 diabetes mellitus. To address this apparent contradiction, lean and ob/ob mice were treated with the LXR agonist GW-3965 for...
article 2005
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TNO Kwaliteit van Leven (author), Goudriaan, J.R. (author), den oer, M.A.M. (author), Rensen, P.C.N. (author), Febbraio, M. (author), Kuipers, F. (author), Romijn, J.A. (author), Havekes, L.M. (author), Voshol, P.J. (author)
CD36 is involved in high-affinity peripheral FFA uptake. CD36-deficient (cd36-/-) mice exhibit increased plasma FFA and triglyceride (TG) levels. The aim of the present study was to elucidate the cause of the increased plasma TG levels in cd36-/- mice. cd36-/- mice showed no differences in hepatic VLDL-TG production or intestinal [3H]TG uptake...
article 2005
Searched for: author:"Kuipers, F."
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