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Wong, M.C. (author), van Diepen, J.A. (author), Hu, L. (author), Guigas, B. (author), de Boer, H.C. (author), van Puijvelde, G.H. (author), Kuiper, J. (author), van Zonneveld, A.J. (author), Shoelson, S.E. (author), Voshol, P.J. (author), Romijn, J.A. (author), Havekes, L.M. (author), Tamsma, J.T. (author), Rensen, P.C.N. (author), Hiemstra, P.S. (author), Berbée, J.F.P. (author)Objective: The liver is the key organ involved in systemic inflammation, but the relation between hepatic inflammation and atherogenesis is poorly understood. Since nuclear factor-κB (NF-κB) is a central regulator of inflammatory processes, we hypothesized that chronically enhanced hepatic NF-κB activation, through hepatocyte-specific expression...article 2012
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TNO Kwaliteit van Leven (author), Venema, A. (author), van Eijk, V. (author), Kuiper, J. (author), Drupsteen, L. (author), Giesbertz, P. (author), Bloemhoff, A. (author), Brinkhuis, B. (author), Jansen, W. (author)Eind 2006 is het onderzoeksproject Aanrijdgevaar Wegwerkers gestart. De meeste werkzaamheden daarvan zijn uitgevoerd in de eerste helft van 2007 door TNO Kwaliteit van Leven en Consument en Veiligheid in opdracht van en in samenwerking met Van den Berg Infrastructuren. Het project moest inzicht geven in de meest voorkomende oorzaken en...report 2008
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TNO Kwaliteit van Leven (author), Venema, A. (author), van Eijk, V. (author), Kuiper, J. (author), Drupsteen, L. (author), Bloemhoff, A. (author), Brinkhuis, B. (author), Jansen, W. (author)Door de omvang en aard van het risico dat wegwervers lopen te worden aangereden is weinig bekend. Van den Berg Infrastructuur heeft het initiatief genomen tot een onderzoeksproject waarbij verschillende methodes werden gebruikt om informatie te verzamelen. Gebleken is dat wegwerkzaamheden niet zonder risico's zijn. Aanrijdgevaar wordt niet...article 2008
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TNO Kwaliteit van Leven (author), Kuiper, J. (author), Giesbertz, P. (author), Bloemhoff, A. (author)Eind 2006 is het onderzoeksproject Aanrijdgevaar Wegwerkers gestart. De meeste werkzaamheden daarvan zijn uitgevoerd in de eerste helft van 2007 door TNO Kwaliteit van Leven en Consument en Veiligheid in opdracht van en in samenwerking met Van den Berg Infrastructuren. Het project bestaat uit verschillende onderzoeken waarvan de opzet en...report 2007
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- van der Kaaden, M.E. (author), Rijken, D.C. (author), van Berkel, T.J.C. (author), Kuiper, J. (author), Gaubius Instituut TNO (author) article 1998
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van der Kaaden, M.E. (author), Rijken, D.C. (author), Kruijt, J.K. (author), van Berkel, T.J.C. (author), Kuiper, J. (author), TNO Preventie en Gezondheid (author)Urokinase-type plasminogen activator (u-PA) is used as a thrombolytic agent in the treatment of acute myocardial infarction. In vitro, recombinant single-chain u-PA (rscu-PA) expressed in E. coli is recognized by the Low-Density Lipoprotein Receptor-related Protein (LRP) on rat parenchymal liver cells. In this study we investigated the role of...article 1997
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Rijken, D.C. (author), van der Kaaden, M.E. (author), Groeneveld, E. (author), Barrett-Bergshoeff, M.M. (author), van Thjc, B. (author), Kuiper, J. (author), Gaubius Instituut TNO (author)Urokinase-type plasminogen activator (u-PA) is rapidly cleared from the circulation with a half-life of a few minutes. We have previously shown that non-glycosylated recombinant u-PA is recognized by LRP, whereas urinary u-PA is recognized by the asialoglycoprotein receptor (ASGPr) on liver parenchymal cells. In the present study we...article 1996
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van der Kaaden, M.E. (author), Riiken, D.C. (author), Kruiit, J.K. (author), van Berkel, T. (author), Kuiper, J. (author), TNO Preventie en Gezondheid (author)Urokinase-type plasminogen activator (u-PA) is used as a thrombolytic agent in the treatment of acute myocardial infarction. In vitro, E.coli produced rscu-PA is recognized by LRP on parenchyma! liver cells. In this study we investigated the role of LRP in the liver uptake and plasma clearance of rscu-PA. A preinjection of the LRP inhibitor...article 1996
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Kuiper, J. (author), van Teijlingen, M. (author), Vietsch, H. (author), Rijken, D.C. (author), van Berkel, T.J.C. (author), Blessen, E.A.L. (author), Division of Biopharmaceutics, LACDR, Leiden, Netherlands Gaubius Laboratory TNO Preventie en Gezondheid (author)A major complication of the use of of tissue-type plasminogen activator (t-PA) as fibrinolytic agent is its rapid clearance from the bloodstream. We have studied whether t-PA clearance can be reduced by preventing receptor-mediated endocytosis of t-PA in vivo via the mannose receptor and the low-density lipoprotein receptor related protein (LRP)...article 1996
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Kuiper, J. (author), van 't Hof, A. (author), Otter, M. (author), Biessen, E.A.L. (author), Rijken, D.C. (author), van Berkel, T.J.C. (author), Division of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research, Sylvius Laboratory, P. O. Box 9503, 2300 RA Leiden, Netherlands Gaubius Laboratory, TNO Prevention and Health, P.O. Box 430, 2300 AK Leiden, Netherlands (author)The fibrin-specific thrombolyticum tissue-type plasminogen activator (t-PA) has proven to be a potent drug in several clinical trials, but its clinical application is complicated by the rapid clearance of t-PA from the circulation. The rapid plasma clearance of t-PA results from the uptake of t-PA in the liver. t-PA consists of several domains...article 1996
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TNO Preventie en Gezondheid Gaubius Instituut TNO (author), Biessen, E.A.L. (author), Noorman, F. (author), van Teijlingen, M.E. (author), Kuiper, J. (author), Barrett-Bergshoeff, M.M. (author), Bijsterbosch, M.K. (author), Rijken, D.G. (author), van Berkel, T.J.G. (author)In search of synthetic high affinity ligands for the mannose receptor, we synthesized a series of lysine-based oligomannosides containing two (M2L) to six (M6L5) terminal alpha-D-mannose groups that are connected with the backbone by flexible elongated spacers (16 Å). The synthesized cluster mannosides were all able to displace binding of...article 1996
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Kuiper, J. (author), Otter, M. (author), Voorschuur, A.H. (author), van Zonneveld, A.j. (author), Rijken, D.C. (author), van Berkel, Th.J.C. (author), TNO Preventie en Gezondheid (author)The present study was undertaken in order to determine the recognition site for tissue-type plasminogen activator-plasminogen activator inhibitor type 1 [t-PA-PAI-1] complexes in rat liver in vivo and in vitro. After intravenous injection into rats t-PA-PAI-1 complexes were rapidly removed from the plasma and the liver took up 80% of the...article 1995
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Otter, M. (author), Kuiper, J. (author), Rijken, D. (author), van Zonneveld, A.-J. (author), TNO Preventie en Gezondheid (author)To characterize the primary structure of rat Vn, a cDNA library constructed from freshly isolated rat hepatocytes, was screened with a human Vn cDNA probe. Comparison of the sequence of the obtained rat cDNA clone with the sequences of human, mouse and rabbit Vn cDNA's showed predominantly consensus in the somatomedin B domain, the RGD-sequence...article 1995
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Biessen, E.A.L. (author), Kuiper, J. (author), van Teijlingen, M. (author), Vietsch, H. (author), Bijsterbosch, M.K. (author), Rijken, D.C. (author), van Berkel, T.J.C. (author), Gaubius Instituut TNO (author)Abstractarticle 1995
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Otter, M. (author), Kuiper, J. (author), Bos, R. (author), Rijken, D.C. (author), van Berkel, T.J.C. (author), Gaubius Laboratory Instituut voor verouderings- en vaatziekten onderzoek TNO (author)The interaction of 125I-labelled tissue-type plasminogen activator (125I-t-PA) with freshly isolated rat parenchymal and endothelial liver cells was studied. Binding experiments at 4°C with parenchymal cells and endothelial liver cells indicated the presence of 68000 and 44000 high-affinity t-PA-binding sites, with an apparent K(d) of 3.5 and 4...article 1992
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Gaubius instituut Instituut voor verouderings- en vaatziekten onderzoek TNO (author), Kuiper, J. (author), Rijken, D.C. (author), Munk, G.A. (author), van Berkel, T.J. (author)The plasma clearance and the interaction of high (HMW) and low (LMW) molecular weight single-chain urokinase-type plasminogen activator (scu-PA) with rat liver cells was determined. 125I-Labeled HMW- and LMW-scu-PA were rapidly cleared from plasma with a half-life of 0.45 min and a maximal liver uptake of 55% of the injected dose. Liver uptake...article 1992
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Gaubius Instituut TNO (author), Otter, M. (author), Kuiper, J. (author), Berkel T.J.C. van, (author), Rijken, D.C. (author)Chemicals/CAS: mannose receptor; Mannose, 31103-86-3; PLAT protein, human; Receptors, Cell Surface; Receptors, Immunologic; Recombinant Proteins; Tissue Plasminogen Activator, EC 3.4.21.68.article 1992
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Gaubius Instituut TNO (author), Quax, P.H.A. (author), van den Hoogen, M. (author), Verheijen, J.H. (author), Padro, T. (author), Zeheb, R. (author), Gelehrter, T.D. (author), van Berkel, T.J.C. (author), Kuiper, J. (author), Emeis, J.J. (author)The tissue-specific distribution of tissue-type and urokinase-type plasminogen activator (t-PA and u-PA) and their inhibitor type 1 (PAI-1) was analyzed at mRNA level in five major rat organ tissues. t-PA mRNA was detected in lung, kidney, heart, and liver. u-PA mRNA was detected in kidney and lung. Presence of PA mRNA correlated with the...article 1990
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- Gezondheidsorganisatie TNO Gaubius Instituut TNO (author), Rijken, D.C. (author), Otter, M. (author), Kuiper, J. (author), van Berkel, T.J.C. (author) article 1990
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- Gezondheidsorganisatie TNO Gaubius Instituut TNO (author), Kuiper, J., (author) article 1988
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