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- Meima, M.Y. (author), Blom, W.M. (author), Westerhout, J. (author), Kruizinga, A.G. (author), Remington, B.C. (author), Wheeler, M.W. (author), Houben, G.F. (author) article 2021
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Remington, B.C. (author), Westerhout, J. (author), Dubois, A.E.J. (author), Blom, W.M. (author), Kruizinga, A.G. (author), Taylor, S.L. (author), Houben, G.F. (author), Baumert, J.L. (author)Food allergen threshold dose distributions are used in food allergen risk assessment to determine the level of risk within a food-allergic population to a defined exposure amount of allergenic food protein and to help inform allergen risk management decisions. There has been a long-standing interest in determining threshold dose distributions...article 2021
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Remington, B.C. (author), Westerhout, J. (author), Meima, M.Y. (author), Blom, W.M. (author), Kruizinga, A.G. (author), Wheeler, M.W. (author), Taylor, S.L. (author), Houben, G.F. (author), Baumert, J.L. (author)Food allergy and allergen management are important global public health issues. In 2011, the first iteration of our allergen threshold database (ATDB) was established based on individual NOAELs and LOAELs from oral food challenge in roughly 1750 allergic individuals. Population minimal eliciting dose (EDp) distributions based on this dataset...article 2020
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Houben, G.F. (author), Baumert, J.L. (author), Blom, W.M. (author), Kruizinga, A.G. (author), Meima, M.Y. (author), Remington, B.C. (author), Wheeler, M.W. (author), Westerhout, J. (author), Taylor, S.L. (author)Previously, we published selected Eliciting Dose (ED) values (i.e. ED01 and ED05 values) for 14 allergenic foods, predicted to elicit objective allergic symptoms in 1% and 5%, respectively, of the allergic population (Remington et al., 2020). These ED01 and ED05 values were specifically presented and discussed in the context of establishing...article 2020
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Blom, W.M. (author), van Os-Medendorp, H. (author), Bijlsma, S. (author), van Dijk, A. (author), Kruizinga, A.G. (author), Rubingh, C. (author), Michelsen-Huisman, A.D. (author), Knulst, A.C. (author), Houben, G.F. (author)Unintentional intake of allergens through food products poses a daily risk for allergic patients. Models estimating the risk of reactions mostly use intake data from general population surveys. Our study evaluates the comparability of food intake levels in the general population to those in the food allergic population. Data were collected by a...article 2020
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Westerhout, J. (author), Baumert, J.L. (author), Blom, W.M. (author), Allen, K.J. (author), Ballmer-Weber, B. (author), Crevel, R.W.R. (author), Dubois, A.E.J. (author), Fernández-Rivas, M. (author), Greenhawt, M.J. (author), Hourihane, J.O. (author), Koplin, J.J. (author), Kruizinga, A.G. (author), Le, T.M. (author), Sampson, H.A. (author), Shreffler, W.G. (author), Turner, P.J. (author), Taylor, S.L. (author), Houben, G.F. (author), Remington, B.C. (author)Background: Food allergies are a significant public health issue, and the only effective management option currently available is strict avoidance of all foods containing the allergen. In view of the practical impossibility of limiting risks to zero, quantitative allergen risk assessment and management strategies are needed. Objective: We sought...article 2019
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DunnGalvin, A. (author), Roberts, G. (author), Schnadt, S. (author), Astley, S. (author), Austin, M. (author), Blom, W.M. (author), Baumert, J. (author), Chan, C.H. (author), Crevel, R.W.R. (author), Grimshaw, K.E.C. (author), Kruizinga, A.G. (author), Regent, L. (author), Taylor, S. (author), Walker, M. (author), Mills, E.N.C. (author)Food allergy is a major public health concern with avoidance of the trigger food(s) being central to management by the patient. Food information legislation mandates the declaration of allergenic ingredients; however, the labelling of the unintentional presence of allergens is less defined. Precautionary allergen labelling (PAL) was introduced...article 2019
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Blom, W.M. (author), Remington, B.C. (author), Baumert, J.L. (author), Bucchini, L. (author), Crépet, A. (author), Crevel, R.W.R. (author), Madsen, C.B. (author), Taylor, S.L. (author), Houben, G.F. (author), Kruizinga, A.G. (author)One of the input parameters in food allergy risk assessment is the amount of a given food consumed at an eating occasion. There is no consensus on how to use food consumption data when assessing the risk from unintended allergen presence in food products. A sensitivity analysis was performed to establish the optimal food consumption estimate for...article 2019
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Birot, S. (author), Crépet, A. (author), Remington, B.C. (author), Madsen, C.B. (author), Kruizinga, A.G. (author), Baumert, J.L. (author), Brockhoff, P.B. (author)Peer-reviewed probabilistic methods already predict the probability of an allergic reaction resulting from an accidental exposure to food allergens, however, the methods calculate it in different ways. The available methods utilize the same three major input parameters in the risk model: the risk is estimated from the amount of food consumed,...article 2019
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Blom, W.M. (author), Michelsen-Huisman, A.D. (author), van Os-Medendorp, H. (author), van Duijn, G. (author), de Zeeuw-Brouwer, M.L. (author), Versluis, A. (author), Castenmiller, J.J.M. (author), Noteborn, H.P.J.M. (author), Kruizinga, A.G. (author), Knulst, A.C. (author), Houben, G.F. (author)Background: Accidental allergic reactions to food are frequent and can be severe and even fatal. Objective: We sought to analyze the culprit food products and levels of unexpected allergens in accidental reactions. Methods: A prospective cohort study was conducted in adults (n = 157) with a physician-confirmed diagnosis of food allergy. During a...article 2018
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Birot, S. (author), Madsen, C.B. (author), Kruizinga, A.G. (author), Crépet, A. (author), Christensen, T. (author), Brockhoff, P.B. (author)To prevent allergic reactions, food producers have to be able to make a knowledge based decision on whether to label their products with precautionary labelling. As many manufactured food products are sold in different countries across Europe, the allergen risk assessment should be estimated at the European levels. As currently, there are no pan...article 2018
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Michelsen-Huisman, A.D. (author), van Os-Medendorp, H. (author), Blom, W.M. (author), Versluis, A. (author), Castenmiller, J.J.M. (author), Noteborn, H.P.J.M. (author), Kruizinga, A.G. (author), Houben, G.F. (author), Knulst, A.C. (author)[No abstract available]article 2018
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Birot, S. (author), Madsen, C.B. (author), Kruizinga, A.G. (author), Christensen, T. (author), Crépet, A. (author), Brockhoff, P.B. (author)Food allergic subjects need to avoid the allergenic food that triggers their allergy. However, foods can also contain unintended allergens. Food manufacturers or authorities need to perform a risk assessment to be able to decide if unintended allergen presence constitutes a risk to food allergic consumers. One of the input parameters in risk...article 2017
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Blom, W.M. (author), Kruizinga, A.G. (author), Rubingh, C.M. (author), Remington, B.C. (author), Crevel, R.W.R. (author), Houben, G.F. (author)Refined vegetable oils including refined peanut oil are widely used in foods. Due to shared production processes, refined non-peanut vegetable oils can contain residual peanut proteins. We estimated the predicted number of allergic reactions to residual peanut proteins using probabilistic risk assessment applied to several scenarios involving...article 2017
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Broekman, H. (author), Verhoeckx, K.C. (author), den Hartog Jager, C.F. (author), Kruizinga, A.G. (author), Pronk-Kleinjan, M. (author), Remington, B.C. (author), Bruijnzeel-Koomen, C.A. (author), Houben, G.F. (author), Knulst, A.C. (author)The growing world population motivates the exploration of new sustainable protein sources to ensure food security. Insects such as mealworm (Tenebrio molitor) are promising candidates, with active ongoing marketing efforts within America and Europe. This warrants assessment of the potential risks. Toxicologic and microbiological risks were...article 2016
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Versluis, A. (author), van Os-Medendorp, H. (author), Kruizinga, A.G. (author), marty Blom, W. (author), Houben, G.F. (author), Knulst, A.C. (author)Introduction: Involvement of cofactors, like physical exercise, alcohol consumption and use of several types of medication, are associated with more severe food allergic symptoms. However, there is limited evidence on how often cofactors play a role in food allergic reactions. The study aimed to get more insight into the frequency of exposure to...article 2016
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Dano, D. (author), Remington, B.C. (author), Astier, C. (author), Baumert, J.L. (author), Kruizinga, A.G. (author), Bihain, B.E. (author), Taylor, S.L. (author), Kanny, G. (author)Background: Sesame is a relevant food allergen in France. Compared to other allergens there is a lack of food challenge data and more data could help sesame allergy risk management. The aim of this study is to collect more sesame challenge data and investigate the most efficient food challenge method for future studies. Method: Records of...article 2015
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Remington, B.C. (author), Baumert, J.L. (author), Blom, W.M. (author), Houben, G.F. (author), Taylor, S.L. (author), Kruizinga, A.G. (author)Background Allergens in food may pose a risk to allergic consumers. While there is EU regulation for allergens present as an ingredient, this is not the case for unintended allergen presence (UAP). Food companies use precautionary allergen labels to inform allergic individuals of a potential risk from UAPs. This study investigates the risk of an...article 2015
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Versluis, A. (author), Knulst, A.C. (author), Kruizinga, A.G. (author), Michelsen, A. (author), Houben, G.F. (author), Baumert, J.L. (author), van Os-Medendorp, H. (author)Summary: Food allergic patients have to deal with an avoidance diet. Confusing labelling terms or precautionary labels can result in misinterpretation and risk-taking behaviour. Even those patients that strictly adhere to their diet experience (sometimes severe) unexpected allergic reactions to food. The frequency, severity and causes of such...article 2015
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DunnGalvin, A. (author), Chun-Han, C. (author), Crevel, R. (author), Grimshaw, K. (author), Poms, R. (author), Schnadt, S. (author), Taylor, S.L. (author), Turner, P. (author), Allen, K.J. (author), Austin, M. (author), Baka, A. (author), Baumert, J.L. (author), Baumgartner, S. (author), Beyer, K. (author), Bucchini, L. (author), Fernández-Rivas, M. (author), Grinter, K. (author), Houben, G.F. (author), Hourihane, J. (author), Kenna, F. (author), Kruizinga, A.G. (author), Lack, G. (author), Madsen, C.B. (author), Mills, E.N. (author), Papadopoulos, N.G. (author), Alldrick, A. (author), Regent, L. (author), Sherlock, R. (author), Wal, J.M. (author), Roberts, G. (author)Precautionary allergen labelling (PAL) was introduced by the food industry to help manage and communicate the possibility of reaction from the unintended presence of allergens in foods. However, in its current form, PAL is counter-productive for consumers with food allergies. This review aims to summarise the perspectives of all the key...article 2015