Searched for: author:"Kroese, E.D."
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Kroese, E.D. (author), Leeman, W.R. (author), Buist, H.E. (author)
Deze rapportage betreft de beantwoording van de vraag “Kan (lichamelijk) medisch onderzoek uitwijzen of een bepaald effect op de gezondheid gerelateerd is aan de blootstelling aan HDI?”. De effecten waar het in dit rapport om gaat komen uit het deelproject “Nadelige gezondheidseffecten en ziekten veroorzaakt door blootstelling aan...
report 2020
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Kroese, E.D. (author), Voogd, E. (author), Kwantes, J.H. (author), Leeman, W.R. (author)
report 2020
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Byrne, F.P. (author), Nussbaumer, C.M. (author), Savin, E.J. (author), Milescu, R.A. (author), McElroy, C.R. (author), Clark, J.H. (author), van Vugt-Lussenburg, B.M.A. (author), van der Burg, B. (author), Meima, M.Y. (author), Buist, H.E. (author), Kroese, E.D. (author), Hunt, A.J. (author), Farmer, T.J. (author)
Three dipolar aprotic solvents were designed to possess high dipolarity and low toxicity: N,N,N′,N′-tetrabutylsuccindiamide (TBSA), N,N′-diethyl-N,N′-dibutylsuccindiamide (EBSA), and N,N′-dimethyl-N,N′-dibutylsuccindiamide (MBSA). They were synthesized catalytically by using a K60 silica catalyst in a solventless system. Their water...
article 2020
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Moné, M.J. (author), Pallocca, G. (author), Escher, S.E. (author), Exner, T. (author), Herzler, M. (author), Hougaard Bennekou, S. (author), Kamp, H. (author), Kroese, E.D. (author), Leist, M. (author), Steger-Hartmann, T. (author), van de Water, B. (author)
In 2016, the European Commission launched the EU-ToxRisk research project to develop and promote animal-free approaches in toxicology. The 36 partners of this consortium used in vitro and in silico methods in the context of case studies (CSs). These CSs included both compounds with a highly defined target (e.g. mitochondrial respiratory chain...
article 2020
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Verheij, E.R. (author), Kroese, E.D. (author)
report 2018
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Kroese, E.D. (author), Leeman, W.R. (author), Voogd, E. (author)
report 2018
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Leeman, W.R. (author), Kwantes, J.H. (author), Voogd, E. (author), Kroese, E.D. (author)
report 2018
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Kroese, E.D. (author), Leeman, W.R. (author)
report 2018
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Verheij, E.R. (author), Kroese, E.D. (author)
report 2018
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Kroese, E.D. (author), Leeman, W.R. (author)
In opdracht van het RIVM heeft TNO onderzocht of (lichamelijk) medisch onderzoek kan uitwijzen of een bepaald effect op de gezondheid gerelateerd is aan de blootstelling aan chroom-6.
report 2017
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Zhu, H. (author), Bouhifd, M. (author), Donley, E. (author), Egnash, L. (author), Kleinstreuer, N. (author), Kroese, E.D. (author), Liu, Z. (author), Luechtefeld, T. (author), Palmer, J. (author), Pamies, D. (author), Shen, J. (author), Strauss, V. (author), Wu, S. (author), Hartung, T. (author)
Read-across, i.e., filling toxicological data gaps by relating to similar chemicals for which test data are available, is usually done based on chemical similarity. Besides structure and physico-chemical properties, biological similarity based on biological data adds extra strength to this process. In the simplest case, chemically similar...
article 2016
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Ball, N. (author), Cronin, M.T.D. (author), Shen, J. (author), Blackburn, K. (author), Booth, E.D. (author), Bouhifd, M. (author), Donley, E. (author), Egnash, L. (author), Hastings, C. (author), Juberg, D.R. (author), Kleensang, A. (author), Kleinstreuer, N. (author), Kroese, E.D. (author), Lee, A.C. (author), Luechtefeld, T. (author), Maertens, A. (author), Marty, S. (author), Naciff, J.M. (author), Palmer, J. (author), Pamies, D. (author), Penman, M. (author), Richarz, A.N. (author), Russo, D.P. (author), Stuard, S.B. (author), Patlewicz, G. (author), van Ravenzwaay, B. (author), Wu, S. (author), Zhu, H. (author), Hartung, T. (author)
Grouping of substances and utilizing read-across of data within those groups represents an important data gap filling technique for chemical safety assessments. Categories/analogue groups are typically developed based on structural similarity and, increasingly often, also on mechanistic (biological) similarity. While read-across can play a key...
article 2016
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Woutersen, R.A. (author), Soffers, A.E.M.F. (author), Kroese, E.D. (author), Krul, C.A.M. (author), van der Laan, J.W. (author), van Benthem, J. (author), Luijten, M. (author)
Sub-chronic toxicity studies of 163 non-genotoxic chemicals were evaluated in order to predict the tumour outcome of 24-month rat carcinogenicity studies obtained from the EFSA and ToxRef databases. Hundred eleven of the 148 chemicals that did not induce putative preneoplastic lesions in the sub-chronic study also did not induce tumours in the...
article 2016
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van der Burg, B. (author), Pieterse, B. (author), Rorije, E. (author), Lewin, G. (author), van der Linden, S.C. (author), Man, H.Y. (author), Piersma, A.H. (author), Mangelsdorf, I. (author), Wolterbeek, A.P.M. (author), Kroese, E.D. (author), van Vugt-Lussenburg, B.M.A. (author)
There is a great need for alternative testing methods for reproductive toxicants that are practical, fast, cost-effective and easy to interpret. Previously we followed a pragmatic approach using readily available tests, which was successful in predicting reproductive toxicity of chemicals [13]. This initial battery still contained apical tests...
article 2015
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Buist, H.E. (author), Devito, S. (author), Goldbohm, R.A. (author), Stierum, R.H. (author), Venhorst, J. (author), Kroese, E.D. (author)
Carbon capture and storage (CCS) technologies are considered vital and economic elements for achieving global CO2 reduction targets, and is currently introduced worldwide (for more information on CCS, consult for example the websites of the International Energy Agency (http://www.iea.org/topics/ccs/) and the Global CCS Institute (http://www...
article 2015
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ter Burg, W. (author), Bokkers, B.G.H. (author), Kroese, E.D. (author), Schuur, A.G. (author)
ABSTRACT: Health impact assessments (HIA) have become an important tool for applying evidence-based policy. Recently, the concept of HIA has been introduced in the field of chemical substances. Two main issues are encountered, i.e., the focus of risk assessment is deriving safe levels and on first signs of adverse effects. These adverse effects,...
article 2015
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Van der Burg, B. (author), Wedebye, E.B. (author), Dietrich, D.R. (author), Jaworska, J. (author), Mangelsdorf, I. (author), Paune, E. (author), Schwarz, M. (author), Piersma, A.H. (author), Kroese, E.D. (author)
There is a great need for rapid testing strategies for reproductive toxicity testing, avoiding animal use.The EU Framework program 7 project ChemScreen aimed to fill this gap in a pragmatic manner prefer-ably using validated existing tools and place them in an innovative alternative testing strategy. In ourapproach we combined knowledge on...
article 2015
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Kroese, E.D. (author), Bosgra, S. (author), Buist, H.E. (author), Lewin, G. (author), van der Linden, S.C. (author), Man, H.Y. (author), Piersma, A.H. (author), Rorije, E. (author), Schulpen, S.H.W. (author), Schwarz, M. (author), Uibel, F. (author), van Vugt-Lussenburg, B.M.A. (author), Wolterbeek, A.P.M. (author), van der Burg, B. (author)
Previously we showed a battery consisting of CALUX transcriptional activation assays, the ReProGlo assay, and the embryonic stem cell test, and zebrafish embryotoxicity assay as 'apical' tests to correctly predict developmental toxicity for 11 out of 12 compounds, and to explain the one false negative [7]. Here we report on applying this battery...
article 2015
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Piersma, A.H. (author), Bosgra, S. (author), van Duursen, M.B.M. (author), Hermsen, S.A.B. (author), Jonker, L.R.A. (author), Kroese, E.D. (author), van der Linden, S.C. (author), Man, H. (author), Roelofs, M.J.E. (author), Schulpen, S.H.W. (author), Schwarz, M. (author), Uibel, F. (author), van Vugt-Lussenburg, B.M.A. (author), Westerhout, J. (author), Wolterbeek, A.P.M. (author), van der Burg, B. (author)
The application of alternative methods in developmental and reproductive toxicology is challenging in view of the complexity of mechanisms involved. A battery of complementary test systems may provide a better prediction of developmental and reproductive toxicity than single assays. We tested twelve compounds with varying mechanisms of toxic...
article 2013
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Marvin, H.J.P. (author), Bouwmeester, H. (author), Bakker, M. (author), Kroese, E.D. (author), van de Meent, D. (author), Bourgeois, F. (author), Lokers, R. (author), van der Ham, H. (author), Verhelst, L. (author)
Engineered nanoparticles (ENPs) have gained huge commercial interest because of their unique and size-related physicochemical properties. The diversity and complexity of ENPs is increasing with the introduction of next generation nanoparticles. The current approaches are not able to assess the safety of all types and applications of ENPs....
article 2013
Searched for: author:"Kroese, E.D."
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