document

Spatial variations of levoglucosan in four European study areas

Jedynska, A. (author), Hoek, G. (author), Wang, M. (author), Eeftens, M. (author), Cyrys, J. (author), Beelen, R. (author), Cirach, M. (author), De Nazelle, A. (author), Keuken, M. (author), Visschedijk, A. (author), Nystad, W. (author), Akhlaghi, H.M. (author), Meliefste, K. (author), Nieuwenhuijsen, M. (author), de Hoogh, K. (author), Brunekreef, B. (author), Kooter, I.M. (author)

Relatively little is known about long term effects of wood smoke on population health. A wood combustion marker - levoglucosan - was measured using a standardized sampling and measurement method in four European study areas (Oslo, The Netherlands, Munich/Augsburg, Catalonia) to assess within and between study area spatial variation. Levoglucosan...

article 2015

document

Chemical chacterization of biofuel exhaust emissions

Jedynska, A.D. (author), Tromp, P.C. (author), Houtzager, M.M.G. (author), Kooter, I.M. (author)

Use of biodiesel is increasing following implementation of various policy instruments and a surge in demand due to growing urbanized populations. A series of experiments to characterize the chemical composition of emissions generated during combustion of petro-diesel (B0), biodiesel blends (B5, B10, B20), biodiesel (B100) and pure plant oil were...

article 2015

document

Health effects of soy-biodiesel emissions: Mutagenicity-emission factors.

Mutlu, E. (author), Warren, S.H. (author), Matthews, P.P. (author), King, C. (author), Walsh, L. (author), Kligerman, A.D. (author), Schmid, J.E (author), Janek, D. (author), Kooter, I.M. (author), Linak, W.P (author), Gilmour, M.I (author), DeMarini, D.M. (author)

CONTEXT: Soy biodiesel is the predominant biodiesel fuel used in the USA, but only a few, frequently conflicting studies have examined the potential health effects of its emissions.

article 2015

document

Natural-cause mortality and long-term exposure to particle components: An Analysis of 19 European cohorts within the multi-center ESCAPE project

Beelen, R. (author), Hoek, G. (author), Raaschou-Nielsen, O. (author), Stafoggia, M. (author), Andersen, Z.J. (author), Weinmayr, G. (author), Hoffmann, B. (author), Wolf, K. (author), Samoli, E. (author), Fischer, P.H. (author), Nieuwenhuijsen, M.J. (author), Xun, W.W. (author), Katsouyanni, K. (author), Dimakopoulou, K. (author), Marcon, A. (author), Vartiainen, E. (author), Lanki, T. (author), Yli-Tuomi, T. (author), Oftedal, B. (author), Schwarze, P.E. (author), Nafstad, P. (author), de Faire, U. (author), Pedersen, N.L. (author), Östenson, C.-G. (author), Fratiglioni, L. (author), Penell, J. (author), Korek, M. (author), Pershagen, G. (author), Eriksen, K.T. (author), Overvad, K. (author), Sørensen, M. (author), Eeftens, M. (author), Peeters, P.H. (author), Meliefste, K. (author), Wang, M. (author), Bas Bueno-De-Mesquita, H. (author), Sugiri, D. (author), Krämer, U. (author), Heinrich, J. (author), De Hoogh, K. (author), Key, T. (author), Peters, A. (author), Hampel, R. (author), Concin, H. (author), Nagel, G. (author), Jaensch, A. (author), Ineichen, A. (author), Tsai, M.-Y. (author), Schaffner, E. (author), Probst-Hensch, N.M. (author), Schindler, C. (author), Ragettli, M.S. (author), Vilier, A. (author), Clavel-Chapelon, F. (author), Declercq, C. (author), Ricceri, F. (author), Sacerdote, C. (author), Galassi, C. (author), Migliore, E. (author), Ranzi, A. (author), Cesaroni, G. (author), Badaloni, C. (author), Forastiere, F. (author), Katsoulis, M. (author), Trichopoulou, A. (author), Keuken, M. (author), Jedynska, A. (author), Kooter, I.M. (author), Kukkonen, J. (author), Sokhi, R.S. (author), Vineis, P. (author), Brunekreef, B. (author)

Background: Studies have shown associations between mortality and long-term exposure to particulate matter air pollution. Few cohort studies have estimated the effects of the elemental composition of particulate matter on mortality. oBjectives: Our aim was to study the association between natural-cause mortality and long-term exposure to...

article 2015

document

Health effects of soy-biodiesel emissions: Bioassay-directed fractionation for mutagenicity.

Mutlu, E. (author), Warren, S.H. (author), Matthews, P.P. (author), Schmid, J.E. (author), Kooter, I.M. (author), Linak, W.P. (author), Gilmour, I. (author), DeMarini, D.M. (author)

CONTEXT: Soy biodiesel is the predominant biodiesel in the USA, but there is little understanding of the classes of chemicals responsible for the mutagenicity of its emissions. OBJECTIVE: We determined some of the chemical classes responsible for the mutagenicity of the particulate matter (PM) of the emissions from petroleum diesel (B0) and...

article 2015

document

Development of land use regression models for elemental, organic carbon, PAH, and hopanes/steranes in 10 ESCAPE/TRANSPHORM European study areas

Jedynska, A. (author), Hoek, G. (author), Wang, M. (author), Eeftens, M. (author), Cyrys, J. (author), Keuken, M. (author), Ampe, C. (author), Beelen, R. (author), Cesaroni, G. (author), Forastiere, F. (author), Cirach, M. (author), de Hoogh, K. (author), de Nazelle, A. (author), Nystad, W. (author), Declercq, C. (author), Eriksen, K.T. (author), Dimakopoulou, K. (author), Lanki, T. (author), Meliefste, K. (author), Nieuwenhuijsen, M.J. (author), Yli-Tuomi, T. (author), Raaschou-Nielsen, O. (author), Brunekreef, B. (author), Kooter, I.M. (author)

Land use regression (LUR) models have been used to model concentrations of mainly traffic-related air pollutants (nitrogen oxides (NOx), particulate matter (PM) mass or absorbance). Few LUR models are published of PM composition, whereas the interest in health effects related to particle composition is increasing. The aim of our study was to...

article 2014

document

Spatial variations of PAH, hopanes/steranes and EC/OC concentrations within and between European study areas

Jedynska, A. (author), Hoek, G. (author), Eeftens, M. (author), Cyrys, J. (author), Keuken, M. (author), Ampe, C. (author), Beelen, R. (author), Cesaroni, G. (author), Forastiere, F. (author), Cirach, M. (author), de Hoogh, K. (author), de Nazelle, A. (author), Madsen, C. (author), Declercq, C. (author), Eriksen, K.T. (author), Katsouyanni, K. (author), Akhlaghi, H.M. (author), Lanki, T. (author), Meliefste, K. (author), Nieuwenhuijsen, M. (author), Oldenwening, M. (author), Pennanen, A. (author), Raaschou-Nielsen, O. (author), Brunekreef, B. (author), Kooter, I.M. (author)

Limited information is available on the contribution of organic components in particulate matter to health effects related to fine particles. Spatial variability of specific fine particle organic components has not been assessed with consistent methods. The aim of this paper is to assess spatial variation of organic components of fine particles...

article 2014

document

Spatial variability of trace elements and sources for improved exposure assessment in Barcelona

Minguillón, M.C. (author), Cirach, M. (author), Hoek, G. (author), Brunekreef, B. (author), Tsai, M. (author), de Hoogh, K. (author), Jedynska, A. (author), Kooter, I.M. (author), Nieuwenhuijsen, M. (author), Querol, X. (author)

Trace and major elements concentrations in PM10 and PM2.5 were measured at 20 sites spread in the Barcelona metropolitan area (1 rural background, 6 urban background, 13 road traffic sites) and at 1 reference site. Three 2-week samples per site and size fraction were collected during 2009 using low volume samplers, adding a total of 120 samples....

article 2014

document

Impact of increasing the blend ratio of biodiesel on engine emission associated toxicity. A quick scan by RIVM and TNO

Gerlofs-Nijland, N.E. (author), Vercruijsse, W. (author), Cassee, F.R. (author), Janssen, P. (author), Kadijk, G. (author), Kooter, I.M. (author), Verbeek, R.P. (author), van Zyl, P.S. (author), Jedynska, A.D. (author), Koornneef, G.P. (author)

There are no strong indications that mixing FAME (Fatty Acid Methyl Ester) biodiesel up to 7 vol%2 and HVO (Hydrotreated Vegetable Oil) biodiesel up to 30 vol% will result in significant increase in harmful emissions by road traffic. This conclusion is based on the limited toxicological data suggesting low or negligible changes in the hazard...

report 2014

document

Toxicity assessment of aggregated/agglomerated cerium oxide nanoparticles in an in vitro 3D airway model: The influence of mucociliary clearance

Kuper, C.F. (author), Gröllers-Mulderij, M. (author), Maarschalkerweerd, T. (author), Meulendijks, N.M.M. (author), Reus, A. (author), van Acker, F. (author), Zondervan-van den Beuken, E.K. (author), Wouters, M.E.L. (author), Bijlsma, S. (author), Kooter, I.M. (author)

We investigated the toxicity of aggregated nanoparticles of cerium oxide (CeO2) using an in vitro 3D human bronchial epithelial model that included a mucociliary apparatus (MucilAir™). CeO2 was dispersed in saline and applied to the apical surface of the model. CeO2 did not induce distinct effects in the model, whereas it did in BEAS-2B and A549...

article 2014

document

Projected impact of biodiesel on road transport emissions up to 2030 - background report

Kadijk, G. (author), Kooter, I.M. (author), Jedynska, A.D. (author), van Zyl, P.S. (author), Verbeek, R.P. (author), Koornneef, G.P. (author)

report 2014

document

Alveolar epithelial cells (A549) exposed at the air-liquid interface to diesel exhaust: First study in TNO's powertrain test center

Kooter, I.M. (author), Alblas, M.J. (author), Jedynska, A.D. (author), Steenhof, M. (author), Houtzager, M.M.G. (author), van Ras, M.G. (author)

Air–liquid interface (ALI) exposures enable in vitro testing ofmixtures of gases and particles such as diesel exhaust (DE). The main objective of this study was to investigate the feasibility of exposing human lung epithelial cells at the ALI to complete DE generated by a heavy-duty truck in the state-of-the-art TNO powertrain test center. A549...

article 2013

document

Bioassay-directed fractionation and sub-fractionation for mutagenicity and chemical analysis of diesel exhaust particles

Mutlu, E. (author), Warren, S.H. (author), Matthews, P.P. (author), King, C. (author), Linak, W.P. (author), Kooter, I.M. (author), Schmid, J.E. (author), Ross, J.A. (author), Ian Gilmour, M. (author), DeMarini, D.M. (author)

Several types of diesel exhaust particles (DEPs) have been used for toxicology studies, including a highorganic automobile DEP (A-DEP) from Japan, and a low-organic forklift DEP developed by the National Institute of Standards and Technology (N-DEP). However, these DEPs were not characterized extensively for chemical composition or sub...

article 2013

document

Toxicological characterization of diesel engine emissions using biodiesel and a closed soot filter

Kooter, I.M. (author), van Vugt, M.A.T.M. (author), Jedynska, A.D. (author), Tromp, P.C. (author), Houtzager, M.M.G. (author), Verbeek, R.P. (author), Kadijk, G. (author), Mulderij, M. (author), Krul, C.A.M. (author)

This study was designed to determine the toxicity (oxidative stress, cytotoxicity, genotoxicity) in extracts of combustion aerosols. A typical Euro III heavy truck engine was tested over the European Transient Cycle with three different fuels: conventional diesel EN590, biodiesel EN14214 as B100 and blends with conventional diesel (B5, B10, and...

article 2011

document

Exposure to biodiesel exhaust triggers atherosclerotic plaque destabilization through accelerated oxidant stress and apoptosis in the arterial vessel wall

Kooter, I.M. (author), Jedynska, A.D. (author), Kilinc, E. (author), Borissoff, J.I. (author), Haegens, A. (author), Tjwa, D.J.T.H. (author), Spronk, H.M.H. (author), ten Cate, H. (author)

bookPart 2011

document

Chemiluminescent reductive acridinium triggering (CRAT) - mechanism and applications

Kooter, I.M. (author), Jedynska, A.D. (author), Zomer, B. (author), Collé, L. (author), Pasterkamp, G. (author), Bloemen, H. (author)

Acridinium esters traditionally are triggered using basic hydrogen peroxide. By serendipity, we have found that acridinium esters can also be triggered with emission of chemiluminescence by reductive triggering, e.g., by zinc metal or reduced forms of ferric and cupric salts. Furthermore, organic reducing compounds like dithiothreitol,...

article 2011

document

Diesel engine exhaust initiates a sequence of pulmonary and cardiovascular effects in rats

Kooter, I.M. (author), Gerlofs-Nijland, M.E. (author), Boere, A.J.F. (author), Leseman, D.L.A.C. (author), Fokkens, P.H.B. (author), Spronk, H.M.H. (author), Frederix, K. (author), Ten Cate, H. (author), Knaapen, A.M. (author), Vreman, H.J. (author), Cassee, F.R. (author)

This study was designed to determine the sequence of events leading to cardiopulmonary effects following acute inhalation of diesel engine exhaust in rats. Rats were exposed for 2h to diesel engine exhaust (1.9mg/m³), and biological parameters related to antioxidant defense, inflammation, and procoagulation were examined after 4, 18,...

article 2010

document

Health effects of biofuel exhaust

TNO Industrie en Techniek (author), van Vugt, M.A.T.M. (author), Mulderij, M. (author), Usta, M. (author), Kadijk, G. (author), Kooter, I.M. (author), Krul, C.A.M. (author)

Alternatives to fossil fuels receive a lot of attention. In particular, oil derived of specific crops forms a promising fuel. In order to warrant global expectance of such novel fuels, safety issues associated with combustion of these fuels needs to be assessed. Although only a few public reports exist, recently potential toxic effects...

other 2009

document

Onderzoek naar het effect van retrofit roetfilters op de emissies van personenwagens met een dieselmotor

TNO Industrie en Techniek (author), Verbeek, R.P. (author), Vermeulen, R.J. (author), Krul, C.A.M. (author), Kooter, I.M. (author), Houtzager, M.M.G. (author)

report 2007