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- Lubczynska, M.J. (author), Muetzel, R.L. (author), el Marroun, H. (author), Hoek, G. (author), Kooter, I.M. (author), Thomson, E.M. (author), Hillegers, M. (author), Vernooij, M.W. (author), White, T. (author), Tiemeier, H. (author), Guxens, M. (author) article 2021
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Bronsveld, P.C.P. (author), Hoppener, E.M. (author), Kooter, I.M. (author)waters.report 2021
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Ndika, J. (author), Ilves, M. (author), Kooter, I.M. (author), Grollers-Mulderij, M. (author), Duistermaat, E. (author), Tromp, P.C. (author), Kuper, F. (author), Kinaret, P. (author), Greco, D. (author), Karisola, P. (author), Alenius, H. (author)The diversity and increasing prevalence of products derived from engineered nanomaterials (ENM), warrants implementation of non-animal approaches to health hazard assessment for ethical and practical reasons. Although non-animal approaches are becoming increasingly popular, there are almost no studies of side-by-side comparisons with traditional...article 2020
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Champion, W.M. (author), Warren, S.H. (author), Kooter, I.M. (author), Preston, W. (author), Krantz, Q.T. (author), DeMarini, D.M. (author), Jetter, J.J. (author)Chemicals / CAS Air Pollutants; Environmental Pollutants; Mutagens; Particulate Matterarticle 2020
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Kooter, I.M. (author)Een onderzoeksprogramma van ZonMw gaat de gezondheidseffecten van het plastic fijnstof dat we dagelijks inademen en doorslikken in kaart brengen. De enorme diversiteit stelt onderzoekers voor grote analytische uitdagingen.article 2019
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Kooter, I.M. (author), Ilves, M. (author), Grollers-Mulderij, M. (author), Duistermaat, E. (author), Tromp, P.C. (author), Kuper, F. (author), Kinaret, P. (author), Savolainen, K. (author), Greco, D. (author), Karisola, P. (author), Ndika, J. (author), Alenius, H. (author)More than 5% of any population suffers from asthma, and there are indications that these individuals are more sensitive to nanoparticle aerosols than the healthy population. We used an air–liquid interface model of inhalation exposure to investigate global transcriptomic responses in reconstituted three-dimensional airway epithelia of healthy...article 2019
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Dankers, A.C.A. (author), Kuper, C.F. (author), Boumeester, A.J. (author), Fabriek, B.O. (author), Kooter, I.M. (author), Gröllers-Mulderij, M. (author), Tromp, P. (author), Nelissen, I. (author), Zondervan-Van Den Beuken, E.K. (author), Vandebriel, R.J. (author)Exposure of humans to metal oxide nanoparticles (NPs) occurs mainly via air, and inhaled metal oxide NPs may generate inflammation. The aim of this study was to investigate the proinflammatory potential of six metal oxide NPs (CeO2, Mn2O3, CuO, ZnO, Co3O4 and WO3; 27–108 μg ml−1) using human primary 3-dimensional airway epithelium (MucilAir™)...article 2018
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Zarcone, M.C. (author), Duistermaat, E. (author), Alblas, M.J. (author), van Schadewijk, A. (author), Ninaber, D.K. (author), Clarijs, V. (author), Moerman, M.M. (author), Vaessen, D. (author), Hiemstra, P.S. (author), Kooter, I.M. (author)Harmful effects of diesel emissions can be investigated via exposures of human epithelial cells, but most of previous studies have largely focused on the use of diesel particles or emission sources that are poorly representative of engines used in current traffic. We studied the cellular response of primary bronchial epithelial cells (PBECs) at...article 2018
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LaCroix, G. (author), Koch, W. (author), Ritter, D. (author), Gutleb, A.C. (author), Larsen, S.T. (author), Loret, T. (author), Zanetti, F. (author), Constant, S. (author), Chortarea, S. (author), Rothen-Rutishauser, B. (author), Hiemstra, P.S. (author), Frejafan, E. (author), Hubert, P. (author), Gribaldo, L. (author), Kearns, P. (author), Aublant, J.M. (author), Diabaté, S. (author), Weiss, C. (author), de Groot, A. (author), Kooter, I.M. (author)In vitro air–liquid interface (ALI) cell culture models can potentially be used to assess inhalation toxicology endpoints and are usually considered, in terms of relevancy, between classic (i.e., submerged) in vitro models and animal-based models. In some situations that need to be clearly defined, ALI methods may represent a complement or an...article 2018
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Hiemstra, P.S. (author), Grootaers, G.G. (author), van der Does, A.M. (author), Krul, C.A.M. (author), Kooter, I.M. (author)The epithelium that covers the conducting airways and alveoli is a primary target for inhaled toxic substances, and therefore a focus in inhalation toxicology. The increasing concern about the use of animal models has stimulated the development of in vitro cell culture models for analysis of the biological effects of inhaled toxicants. However,...article 2018
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Jedynska, A. (author), Hoek, G. (author), Wang, M. (author), Yang, A. (author), Eeftens, M. (author), Cyrys, J. (author), Keuken, M. (author), Ampe, C. (author), Beelen, R. (author), Cesaroni, G. (author), Forastiere, F. (author), Cirach, M. (author), de Hoogh, K. (author), de Nazelle, A. (author), Nystad, W. (author), Akhlaghi, H.M. (author), Declercq, C. (author), Stempfelet, M. (author), Eriksen, K.T. (author), Dimakopoulou, K. (author), Lanki, T. (author), Meliefste, K. (author), Nieuwenhuijsen, M. (author), Yli-Tuomi, T. (author), Raaschou-Nielsen, O. (author), Janssen, N.A.H. (author), Brunekreef, B. (author), Kooter, I.M. (author)Oxidative potential (OP) has been suggested as a health-relevant measure of air pollution. Little information is available about OP spatial variation and the possibility to model its spatial variability. Our aim was to measure the spatial variation of OP within and between 10 European study areas. The second aim was to develop land use...article 2017
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Kooter, I.M. (author), Grollers-Mulderij, M. (author), Duistermaat, E. (author), Kuper, C.F. (author)Mucilair 3D bronchial airway models, cultured at an air-liquid interface, were exposed to aerosols of copper oxide (CuO) nanoparticles in Vitrocell air exposure modules. Four cell donors, four exposure modules and four exposure concentrations were varied within four different exposure sessions using a statistical experimental design called a...article 2017
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Zarcone, M.C. (author), van Schadewijk, A. (author), Duistermaat, E. (author), Hiemstra, P.S. (author), Kooter, I.M. (author)Background: Exacerbations constitute a major cause of morbidity and mortality in patients suffering from chronic obstructive pulmonary disease (COPD). Both bacterial infections, such as those with non-typeable Haemophilus influenzae (NTHi), and exposures to diesel engine emissions are known to contribute to exacerbations in COPD patients....article 2017
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Pedersen, M. (author), Gehring, U. (author), Beelen, R. (author), Wang, M. (author), Giorgis-Allemand, L. (author), Andersen, A.M.N. (author), Basagaña, X. (author), Bernard, C. (author), Cirach, M. (author), Forastiere, F. (author), de Hoogh, K. (author), Gražuleviĉvienė, R. (author), Gruzieva, O. (author), Hoek, G. (author), Jedynska, A. (author), Klümper, C. (author), Kooter, I.M. (author), Krämer, U. (author), Kukkonen, J. (author), Porta, D. (author), Postma, D.S. (author), Raaschou-Nielsen, O. (author), van Rossem, L. (author), Sunyer, J. (author), Sørensen, M. (author), Tsai, M.Y. (author), Vrijkotte, T.G.M. (author), Wilhelm, M. (author), Nieuwenhuijsen, M.J. (author), Pershagen, G. (author), Brunekreef, B. (author), Kogevinas, M. (author), Slama, R. (author)Background: The health effects of suspended particulate matter (PM) may depend on its chemical composition. Associations between maternal exposure to chemical constituents of PM and newborn’s size have been little examined. Objective: We aimed to investigate the associations of exposure to elemental constituents of PM with term low birth weight ...article 2016
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Kooter, I.M. (author), Grollers-Mulderij, M. (author), Steenhof, M. (author), Duistermaat, E. (author), van Acker, F.A.A. (author), Staal, Y.C.M. (author), Tromp, P.C. (author), Schoen, E.D. (author), Kuiper, C.F. (author), van Someren, E.P. (author)There is a need for representative in vitro models to assess the effects of airborne particles on lung health. The ob-jective of this study was to assess the cellular effects of cerium oxide (Ce02) particles exposed via an air—liquid interface in three relevant cell models in parallel. BEAS-2B, A549, and MucilAirTM cells were exposed for 1 hour...article 2016
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Cellular response of mucociliary differentiated primary bronchial epithelial cells to diesel exhaustZarcone, M.C. (author), Duistermaat, E. (author), van Schadewijk, A. (author), Jedynksa, A.D. (author), Hiemstra, P.S. (author), Kooter, I.M. (author)Cellular response of mucociliary differentiated primary bronchial epithelial cells to diesel exhaust. Am J Physiol Lung Cell Mol Physiol 311: L111–L123, 2016. First published May 17, 2016; doi:10.1152/ajplung.00064.2016.—Diesel emissions are the main source of air pollution in urban areas, and diesel exposure is linked with substantial adverse...article 2016
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Mutlu, E. (author), Warren, S.H. (author), Ebersviller, S.M. (author), Kooter, I.M. (author), Schmid, J.E. (author), Dye, J.A. (author), Linak, W.P. (author), Gilmour, M.I. (author), Jetter, J.J. (author), Higuchi, M. (author), DeMarini, D.M. (author)Background: Emissions from solid fuels used for cooking cause ~4 million premature deathsarticle 2016
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Mutlu, E. (author), Nash, D.G. (author), King, C. (author), Krantz, T.Q. (author), Preston, W.T. (author), Kooter, I.M. (author), Higuchi, M. (author), DeMarini, D. (author), Linak, W.P. (author), Ian Gilmour, M. (author)Biodiesel made from the transesterification of plant- and animal-derived oils is an important alternative fuel source for diesel engines. Although numerous studies have reported health effects associated with petroleum diesel emissions, information on biodiesel emissions are more limited. To this end, a program at the U.S. EPA assessed health...article 2015
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Jedynska, A. (author), Hoek, G. (author), Wang, M. (author), Eeftens, M. (author), Cyrys, J. (author), Beelen, R. (author), Cirach, M. (author), De Nazelle, A. (author), Keuken, M. (author), Visschedijk, A. (author), Nystad, W. (author), Akhlaghi, H.M. (author), Meliefste, K. (author), Nieuwenhuijsen, M. (author), de Hoogh, K. (author), Brunekreef, B. (author), Kooter, I.M. (author)Relatively little is known about long term effects of wood smoke on population health. A wood combustion marker - levoglucosan - was measured using a standardized sampling and measurement method in four European study areas (Oslo, The Netherlands, Munich/Augsburg, Catalonia) to assess within and between study area spatial variation. Levoglucosan...article 2015
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Jedynska, A.D. (author), Tromp, P.C. (author), Houtzager, M.M.G. (author), Kooter, I.M. (author)Use of biodiesel is increasing following implementation of various policy instruments and a surge in demand due to growing urbanized populations. A series of experiments to characterize the chemical composition of emissions generated during combustion of petro-diesel (B0), biodiesel blends (B5, B10, B20), biodiesel (B100) and pure plant oil were...article 2015
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