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Beter onderscheid in fijnstofdeeltjes leidt tot meer gezondheidswinst

Denier van der Gon, H.A.C. (author), Bronsveld, P.C.P. (author), Kooter, I.M. (author), Kostanje, T.J. (author), Hartendorf, F.H. (author)

Sinds 2015 daalt de fijnstofconcentratie niet meer, terwijl er nog grote gezondheidsschade is. Hoe nu verder? De schadelijkste deeltjes aan pakken op plekken waar veel mensen worden blootgesteld biedt de grootste gezondheidswinst.

article 2022

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Advanced epithelial lung and gut barrier models demonstrate passage of microplastic particles

Donkers, J.M. (author), Hoppener, E.M. (author), Grigoriev, I. (author), Will, L. (author), Melgert, B.N. (author), van der Zaan, B. (author), van de Steeg, E. (author), Kooter, I.M. (author)

Micro- and nanoplastics (MNP) can be found virtually everywhere around us in the biosphere and food chain, therefore humans are continuously exposed to MNP, mainly via inhalation and ingestion. Here, we have applied physiologically relevant human-based advanced in vitro models representing the lung (MucilAir™) and gut (InTESTine™ and Intestinal...

article 2022

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Air pollution exposure during pregnancy and childhood and brain morphology in preadolescents

Lubczynska, M.J. (author), Muetzel, R.L. (author), el Marroun, H. (author), Hoek, G. (author), Kooter, I.M. (author), Thomson, E.M. (author), Hillegers, M. (author), Vernooij, M.W. (author), White, T. (author), Tiemeier, H. (author), Guxens, M. (author)

article 2021

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Adviesrapport inventarisatie uniforme meetmethode voor microplastic vezels uit textiel [Advisory report inventory uniform measuring method for microplastic fibres from textiles]

Bronsveld, P.C.P. (author), Hoppener, E.M. (author), Kooter, I.M. (author)

In 2018, RIVM conducted research into the sources of microplastics (MP) in Dutch waters. From this and other studies, microplastic fibres (MPVs), created during wearing and washing of clothes, emerged as one of the largest sources of microplastics1. With support from the Ministry of Infrastructure and Water Management (I&W), the MPV ...

report 2021

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Mutagenicity- and pollutant-emission factors of pellet-fueled gasifier cookstoves Comparison with other combustion sources

Champion, W.M. (author), Warren, S.H. (author), Kooter, I.M. (author), Preston, W. (author), Krantz, Q.T. (author), DeMarini, D.M. (author), Jetter, J.J. (author)

Chemicals / CAS Air Pollutants; Environmental Pollutants; Mutagens; Particulate Matter

article 2020

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Mechanistic Similarities between 3D Human Bronchial Epithelium and Mice Lung, Exposed to Copper Oxide Nanoparticles, Support Non-Animal Methods for Hazard Assessment

Ndika, J. (author), Ilves, M. (author), Kooter, I.M. (author), Grollers-Mulderij, M. (author), Duistermaat, E. (author), Tromp, P.C. (author), Kuper, F. (author), Kinaret, P. (author), Greco, D. (author), Karisola, P. (author), Alenius, H. (author)

The diversity and increasing prevalence of products derived from engineered nanomaterials (ENM), warrants implementation of non-animal approaches to health hazard assessment for ethical and practical reasons. Although non-animal approaches are becoming increasingly popular, there are almost no studies of side-by-side comparisons with traditional...

article 2020

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Wat doet microplastic in ons lichaam?

Kooter, I.M. (author)

Een onderzoeksprogramma van ZonMw gaat de gezondheidseffecten van het plastic fijnstof dat we dagelijks inademen en doorslikken in kaart brengen. De enorme diversiteit stelt onderzoekers voor grote analytische uitdagingen.

article 2019

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Molecular signature of asthma-enhanced sensitivity to cuo nanoparticle aerosols from 3d cell modell

Kooter, I.M. (author), Ilves, M. (author), Grollers-Mulderij, M. (author), Duistermaat, E. (author), Tromp, P.C. (author), Kuper, F. (author), Kinaret, P. (author), Savolainen, K. (author), Greco, D. (author), Karisola, P. (author), Ndika, J. (author), Alenius, H. (author)

More than 5% of any population suffers from asthma, and there are indications that these individuals are more sensitive to nanoparticle aerosols than the healthy population. We used an air–liquid interface model of inhalation exposure to investigate global transcriptomic responses in reconstituted three-dimensional airway epithelia of healthy...

article 2019

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A practical approach to assess inhalation toxicity of metal oxide nanoparticles in vitro

Dankers, A.C.A. (author), Kuper, C.F. (author), Boumeester, A.J. (author), Fabriek, B.O. (author), Kooter, I.M. (author), Gröllers-Mulderij, M. (author), Tromp, P. (author), Nelissen, I. (author), Zondervan-Van Den Beuken, E.K. (author), Vandebriel, R.J. (author)

Exposure of humans to metal oxide nanoparticles (NPs) occurs mainly via air, and inhaled metal oxide NPs may generate inflammation. The aim of this study was to investigate the proinflammatory potential of six metal oxide NPs (CeO2, Mn2O3, CuO, ZnO, Co3O4 and WO3; 27–108 μg ml−1) using human primary 3-dimensional airway epithelium (MucilAir™)...

article 2018

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Air-liquid interface In Vitro models for respiratory toxicology research: Consensus workshop and recommendations

LaCroix, G. (author), Koch, W. (author), Ritter, D. (author), Gutleb, A.C. (author), Larsen, S.T. (author), Loret, T. (author), Zanetti, F. (author), Constant, S. (author), Chortarea, S. (author), Rothen-Rutishauser, B. (author), Hiemstra, P.S. (author), Frejafan, E. (author), Hubert, P. (author), Gribaldo, L. (author), Kearns, P. (author), Aublant, J.M. (author), Diabaté, S. (author), Weiss, C. (author), de Groot, A. (author), Kooter, I.M. (author)

In vitro air–liquid interface (ALI) cell culture models can potentially be used to assess inhalation toxicology endpoints and are usually considered, in terms of relevancy, between classic (i.e., submerged) in vitro models and animal-based models. In some situations that need to be clearly defined, ALI methods may represent a complement or an...

article 2018

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Human lung epithelial cell cultures for analysis of inhaled toxicants: Lessons learned and future directions

Hiemstra, P.S. (author), Grootaers, G.G. (author), van der Does, A.M. (author), Krul, C.A.M. (author), Kooter, I.M. (author)

The epithelium that covers the conducting airways and alveoli is a primary target for inhaled toxic substances, and therefore a focus in inhalation toxicology. The increasing concern about the use of animal models has stimulated the development of in vitro cell culture models for analysis of the biological effects of inhaled toxicants. However,...

article 2018

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Effect of diesel exhaust generated by a city bus engine on stress responses and innate immunity in primary bronchial epithelial cell cultures

Zarcone, M.C. (author), Duistermaat, E. (author), Alblas, M.J. (author), van Schadewijk, A. (author), Ninaber, D.K. (author), Clarijs, V. (author), Moerman, M.M. (author), Vaessen, D. (author), Hiemstra, P.S. (author), Kooter, I.M. (author)

Harmful effects of diesel emissions can be investigated via exposures of human epithelial cells, but most of previous studies have largely focused on the use of diesel particles or emission sources that are poorly representative of engines used in current traffic. We studied the cellular response of primary bronchial epithelial cells (PBECs) at...

article 2018

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Spatial variations and development of land use regression models of oxidative potential in ten European study areas

Jedynska, A. (author), Hoek, G. (author), Wang, M. (author), Yang, A. (author), Eeftens, M. (author), Cyrys, J. (author), Keuken, M. (author), Ampe, C. (author), Beelen, R. (author), Cesaroni, G. (author), Forastiere, F. (author), Cirach, M. (author), de Hoogh, K. (author), de Nazelle, A. (author), Nystad, W. (author), Akhlaghi, H.M. (author), Declercq, C. (author), Stempfelet, M. (author), Eriksen, K.T. (author), Dimakopoulou, K. (author), Lanki, T. (author), Meliefste, K. (author), Nieuwenhuijsen, M. (author), Yli-Tuomi, T. (author), Raaschou-Nielsen, O. (author), Janssen, N.A.H. (author), Brunekreef, B. (author), Kooter, I.M. (author)

Oxidative potential (OP) has been suggested as a health-relevant measure of air pollution. Little information is available about OP spatial variation and the possibility to model its spatial variability. Our aim was to measure the spatial variation of OP within and between 10 European study areas. The second aim was to develop land use...

article 2017

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Factors of concern in a human 3D cellular airway model to aerosols of nanoparticles

Kooter, I.M. (author), Grollers-Mulderij, M. (author), Duistermaat, E. (author), Kuper, C.F. (author)

Mucilair 3D bronchial airway models, cultured at an air-liquid interface, were exposed to aerosols of copper oxide (CuO) nanoparticles in Vitrocell air exposure modules. Four cell donors, four exposure modules and four exposure concentrations were varied within four different exposure sessions using a statistical experimental design called a...

article 2017

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Diesel exhaust alters the response of cultured primary bronchial epithelial cells from patients with chronic obstructive pulmonary disease (COPD) to non-typeable Haemophilus influenzae

Zarcone, M.C. (author), van Schadewijk, A. (author), Duistermaat, E. (author), Hiemstra, P.S. (author), Kooter, I.M. (author)

Background: Exacerbations constitute a major cause of morbidity and mortality in patients suffering from chronic obstructive pulmonary disease (COPD). Both bacterial infections, such as those with non-typeable Haemophilus influenzae (NTHi), and exposures to diesel engine emissions are known to contribute to exacerbations in COPD patients....

article 2017

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Elemental constituents of particulate matter and newborn’s size in eight European cohorts

Pedersen, M. (author), Gehring, U. (author), Beelen, R. (author), Wang, M. (author), Giorgis-Allemand, L. (author), Andersen, A.M.N. (author), Basagaña, X. (author), Bernard, C. (author), Cirach, M. (author), Forastiere, F. (author), de Hoogh, K. (author), Gražuleviĉvienė, R. (author), Gruzieva, O. (author), Hoek, G. (author), Jedynska, A. (author), Klümper, C. (author), Kooter, I.M. (author), Krämer, U. (author), Kukkonen, J. (author), Porta, D. (author), Postma, D.S. (author), Raaschou-Nielsen, O. (author), van Rossem, L. (author), Sunyer, J. (author), Sørensen, M. (author), Tsai, M.Y. (author), Vrijkotte, T.G.M. (author), Wilhelm, M. (author), Nieuwenhuijsen, M.J. (author), Pershagen, G. (author), Brunekreef, B. (author), Kogevinas, M. (author), Slama, R. (author)

Background: The health effects of suspended particulate matter (PM) may depend on its chemical composition. Associations between maternal exposure to chemical constituents of PM and newborn’s size have been little examined. Objective: We aimed to investigate the associations of exposure to elemental constituents of PM with term low birth weight ...

article 2016

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Cellular effects in an in vitro human 3D cellular airway model and A549/BEAS-2B in vitro cell cuultures following air exposure to cerium oxide particles at an air-liquid interface

Kooter, I.M. (author), Grollers-Mulderij, M. (author), Steenhof, M. (author), Duistermaat, E. (author), van Acker, F.A.A. (author), Staal, Y.C.M. (author), Tromp, P.C. (author), Schoen, E.D. (author), Kuiper, C.F. (author), van Someren, E.P. (author)

There is a need for representative in vitro models to assess the effects of airborne particles on lung health. The ob-jective of this study was to assess the cellular effects of cerium oxide (Ce02) particles exposed via an air—liquid interface in three relevant cell models in parallel. BEAS-2B, A549, and MucilAirTM cells were exposed for 1 hour...

article 2016

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Cellular response of mucociliary differentiated primary bronchial epithelial cells to diesel exhaust

Zarcone, M.C. (author), Duistermaat, E. (author), van Schadewijk, A. (author), Jedynksa, A.D. (author), Hiemstra, P.S. (author), Kooter, I.M. (author)

Cellular response of mucociliary differentiated primary bronchial epithelial cells to diesel exhaust. Am J Physiol Lung Cell Mol Physiol 311: L111–L123, 2016. First published May 17, 2016; doi:10.1152/ajplung.00064.2016.—Diesel emissions are the main source of air pollution in urban areas, and diesel exposure is linked with substantial adverse...

article 2016

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Mutagenicity and pollutant emission factors of solid-fuel cookstoves: Comparison with other combustion sources

Mutlu, E. (author), Warren, S.H. (author), Ebersviller, S.M. (author), Kooter, I.M. (author), Schmid, J.E. (author), Dye, J.A. (author), Linak, W.P. (author), Gilmour, M.I. (author), Jetter, J.J. (author), Higuchi, M. (author), DeMarini, D.M. (author)

Background: Emissions from solid fuels used for cooking cause ~4 million premature deaths

article 2016

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Generation and characterization of diesel engine combustion emissions from petroleum diesel and soybean biodiesel fuels and application for inhalation exposure studies.

Mutlu, E. (author), Nash, D.G. (author), King, C. (author), Krantz, T.Q. (author), Preston, W.T. (author), Kooter, I.M. (author), Higuchi, M. (author), DeMarini, D. (author), Linak, W.P. (author), Ian Gilmour, M. (author)

Biodiesel made from the transesterification of plant- and animal-derived oils is an important alternative fuel source for diesel engines. Although numerous studies have reported health effects associated with petroleum diesel emissions, information on biodiesel emissions are more limited. To this end, a program at the U.S. EPA assessed health...

article 2015