Searched for: author:"Koopman, J.L."
(1 - 6 of 6)
document
Koopman, J.L. (author), Slomp, J. (author), de Bart, A.C.W. (author), Quax, P.H.A. (author), Verheijent, J.H. (author), Gaubius Instituut TNO (author)
The structural and functional properties of the urokinase-type plasminogen activator (u-PA) that are involved in the mitogenic effect of this proteolytic enzyme on human melanoma cells M14 and IF6 and the role of the u-PA receptor (u-PAR) in transducing this signal were analyzed. Native u- PA purified from urine induced a mitogenic response in...
article 1998
document
TeKoppele, J.M. (author), Beekman, B. (author), Verzijl, N. (author), Koopman, J.L. (author), de Groot, J. (author), Bank, R.A. (author), Gaubius Instituut TNO (author)
Doxycycline (DOX) profoundly inhibited collagen synthesis by differentiated articular chondrocytes. At 25 microM, the rate of collagen synthesis was suppressed by more than 50% without affecting cell proliferation (DNA levels) and general protein synthesis (35S-Met and 35S-Cys incorporation). Steady-state mRNA levels of type II collagen were...
article 1998
document
Beekman, B. (author), Verzijl, N. (author), de Roos, J.A.D.M. (author), Koopman, J.L. (author), Tekoppele, J.M. (author), Leiden, Netherlands Gaubius Instituut TNO (author)
Doxycycline is known for its ability to inhibit matrix metalloproteinases (MMPs), a family of enzymes that play a role in cartilage breakdown in arthritides. Its prophylactic effect in reducing joint degradation in osteoarthritis is mainly attributed to this property. In this study, we show that doxycycline exhibits a profound inhibition of...
article 1997
document
Koopman, J.L. (author), Slomp, J. (author), de Bart, A.C.W. (author), Quax, P.H.A. (author), Verheijen, J.H. (author), TNO Preventie en gezondheid (author)
article 1996
document
Slomp, J. (author), Koopman, J.L. (author), Quax, P.H.A. (author), de Bart, A.C.W. (author), Hennius, B.C. (author), Nieuwenbroek, N.M.E. (author), Verheijen, J.H. (author), TNO Preventie en gezondheid (author)
abstract
article 1996
document
Koopman, J.L. (author), Instituut voor verouderings- en vaatziekten onderzoek TNO (author), GO IVVO (author)
doctoral thesis 1992
Searched for: author:"Koopman, J.L."
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