Searched for: author%3A%22Knook%2C+D.L.%22
(1 - 20 of 27)

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Wijlhuizen, G.J. (author), Hopman-Rock, M. (author), Knook, D.L. (author), van der Cammen, T.J. (author), TNO Kwaliteit van Leven (author)
article 2006
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Heijmans, B.T. (author), Westendorp, R.G.J. (author), Knook, D.L. (author), Kluft, C. (author), Slagboom, P.E. (author), Gaubius instituut TNO (author)
OBJECTIVES: We studied the contribution of putative risk genotypes at the angiotensin I-converting enzyme inhibitor (ACE D/D) and plasminogen activator inhibitor-1 (PAI-1 4G/4G) loci to all-cause and cardiovascular mortality in a population-based cohort. BACKGROUND: The ACE D/D and PAI-1 4G/4G genotypes have been consistently associated with...
article 1999
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van Buuren, S. (author), Boshuizen, H.C. (author), Knook, D.L. (author), TNO Preventie en Gezondheid (author)
This paper studies a non-response problem in survival analysis where the occurrence of missing data in the risk factor is related to mortality. In a study to determine the influence of blood pressure on survival in the very old (85+ years), blood pressure measurements are missing in about 12.5 per cent of the sample. The available data suggest...
article 1999
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Heijmans, B.T. (author), Westendorp, R.G.J. (author), Knook, D.L. (author), Kluft, C. (author), Slagboom, P.E. (author), Gaubius Instituut TNO (author)
The factor V Leiden mutation (conferring resistance to activated protein C) has been implicated in the risk of arterial thrombosis and is a well-established risk factor for venous thrombosis especially in the elderly. We studied whether the disease association of the factor V mutation is reflected in an increased all-cause and cause-specific...
article 1998
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Heijmans, B.T. (author), Kluft, C. (author), Bots, M.L. (author), Lagaay, A.M. (author), Brand, A. (author), Grobbee, D.E. (author), Knook, D.L. (author), Slagboom, P.E. (author), Gaubius Instituut TNO (author)
The genetic component of human longevity is estimated at 30%. Which genes are involved in determining human longevity, however, is largely unknown. Genes that may affect human survival are susceptibility loci for major age related pathologies. Many studies are being performed to identify such loci for cardiovascular disease, dementia and...
article 1996
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Bergsma, J.H. (author), van Boxtel, J.A.M. (author), Kleijn de Vrankrijker, M.W. (author), Knook, D.L. (author), TNO Preventie en Gezondheid (author)
Abstract
conference paper 1995
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Knook, D.L. (author), Bosma, A. (author), Seifert, W.F. (author), Instituut voor Verouderings- en Vaatziekten Onderzoek TNO (author)
The relationship between vitamin A and liver fibrosis was studied with a CCl4-induced fibrosis model in rats. Depending on the time of administration, vitamin A can potentiate or reduce fibrosis: when present during CCl4-treatment parenchymal cell damage and fibrosis were enhanced, whereas vitamin A post-treatment strongly reduced fibrosis....
article 1995
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Seifert, W.F. (author), Bosma, A. (author), Brouwer, A. (author), Hendriks, H.F.J. (author), Roholl, P.J.M. (author), van Leeuwen, R.E.W. (author), de Thiel van-Ruiter, G.C.F. (author), Seifert-Bock, I. (author), Knook, D.L. (author), TNO Preventie en Gezondheid (author)
Earlier studies have shown that retinoid administration suppresses the generation of hepatic fibrosis and stimulates its regression in normal (i.e., vitamin A-sufficient) carbon tetrachloride-treated rats. This study focuses on the possible role of a marginal or deficient vitamin A status on carbon tetrachloride-induced fibrosis. This...
article 1994
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Knook, D.L. (author), Goedhard, W.J.A. (author), Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author)
Gebaseerd op het 15e Gerontologie symposium 18 maart 1994 te Utrecht.
book 1994
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Bosma, A. (author), Seifert, W.F. (author), de Thiel van - Ruiter, G.C.F. (author), van Leeuwen, R.E.W. (author), Blauw, B. (author), Roholl, P. (author), Knook, D.L. (author), Brouwer, A. (author), Gaubius Laboratory TNO Preventie en Gezondheid Instituut voor verouderings- en vaatziekten onderzoek TNO (author)
Rats were malnourished for 12 months with a highly inadequate fat-rich, calorie-sufficient but otherwise poly-deficient liquid diet composed of mashed potatoes with mayonnaise, comparable with the nutritional intake of many chronic alcoholics. When alcohol was incorporated into this diet, administered as whisky in drinking water available ad...
article 1994
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Knook, D.L. (author), Instituut voor verouderings- en vaatziekten onderzoek TNO (author)
bookPart 1993
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Instituut voor experimentele gerontologie TNO (author), Eulderink, F. (author), Heeren, T.J. (author), Knook, D.L. (author), Ligthart, G.J. (author)
Dit boek bevat wat de basisarts moet weten over veroudering. Het behandelt eerst de belangrijkste aspecten van normale veroudering (Gerontologie), daarna de geneeskunde bij ouderen (Geriatrie) voor zover die anders is dan bij jongeren. Veroudering is het optreden van ogenschijnlijk spontane, irreversibele veranderingen met de tijd. Deze...
book 1993
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Brouwer, A. (author), Seifert, W.F. (author), Bosma, A. (author), van Leeuwen, R.E.W. (author), Hendriks, H.F.J. (author), Knook, D.L. (author), Gezondheidsorganisatie TNO Instituut voor verouderings- en vaatziekten onderzoek TNO Instituut voor toxicologie en voeding TNO (author)
conference paper 1992
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Bosma, A. (author), Seifert, W.F. (author), Wilson, J.H.P. (author), Roholl, P.J.M. (author), Brouwer, A. (author), Knook, D.L. (author), Instituut voor Verouderings- en Vaatziekten Onderzoek TNO (author)
Rats of two strains (BN/BiRij and WAG/Rij) were fed the ethanol-containing Lieber-De Carli liquid diet supplemented with high amounts of vitamin A for 16 months. In contrast to Lieber and co-workers, who showed liver fibrosis developing within 9 months on the same diet in Sprague-Dawley rats, we were unable to demonstrate a histological and...
article 1991
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Gezondheidsorganisatie TNO Instituut voor Verouderings- en Vaatziekten Onderzoek TNO (author), Pieters, M.N. (author), Schouten, D. (author), Bakkeren, H.F. (author), Esbach, B. (author), Brouwer, A. (author), Knook, D.L. (author), van van Berkel, T.J. (author)
[3H]Cholesteryl ester-labelled human high-density lipoprotein (HDL) was injected into rats and its decay, intrahepatic cellular distribution and the kinetics of biliary secretion were determined. At 10 min after injection the hepatic uptake of cholesteryl esters from HDL was 3-fold higher as compared with the apolipoprotein. Selective uptake was...
article 1991
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Gezondheidsorganisatie TNO Instituut voor Experimentele Gerontologie TNO (author), Courtois, Y. (author), Faucheux, B. (author), Forette, B. (author), Knook, D.L. (author), Tréton, J.A. (author)
conference paper 1986
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Knook, D.L. (author), Goedhard, W.J.A. (author), Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author)
book 1985
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Instituut voor experimentele gerontologie TNO (author), Brouwer, A. (author), Knook, D.L. (author)
This review represents an attempt to summarize and evaluate the literature data on the changes occurring in the reticuloendothelial system (RES) during aging. The RES is briefly introduced with emphasis on cellular composition, function, physiology, regulation and the methods employed for assessment of its functions. The age-related changes in...
article 1983
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Praaning-Van Dalen, D.P. (author), Brouwer, A. (author), Knook, D.L. (author)
article 1982
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Instituut voor experimentele gerontologie TNO (author), Praaning-Van Dalen, D.P. (author), Knook, D.L. (author)
Chemicals/CAS: Serum Albumin, Bovine
article 1982
Searched for: author%3A%22Knook%2C+D.L.%22
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