Searched for: author:"Kamp, H."
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Rovida, C. (author), Escher, S.E. (author), Herzler, M. (author), Bennekou, S.H. (author), Kamp, H. (author), Kroese, D.E. (author), Maslankiewicz, L. (author), Moné, M.J. (author), Patlewicz, G. (author), Sipes, N. (author), van Aerts, L. (author), White, A. (author), Yamada, T. (author), van de Water, B. (author)
The use of new approach methodologies (NAMs) in support of read-across (RAx) approaches for regulatory purposes is a main goal of the EU-ToxRisk project. To bring this forward, EU-ToxRisk partners convened a workshop in close collaboration with regulatory representatives from key organizations including European regulatory agencies, such as the...
article 2021
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Moné, M.J. (author), Pallocca, G. (author), Escher, S.E. (author), Exner, T. (author), Herzler, M. (author), Hougaard Bennekou, S. (author), Kamp, H. (author), Kroese, E.D. (author), Leist, M. (author), Steger-Hartmann, T. (author), van de Water, B. (author)
In 2016, the European Commission launched the EU-ToxRisk research project to develop and promote animal-free approaches in toxicology. The 36 partners of this consortium used in vitro and in silico methods in the context of case studies (CSs). These CSs included both compounds with a highly defined target (e.g. mitochondrial respiratory chain...
article 2020
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Escher, S.E. (author), Kamp, H. (author), Bennekou, S.H. (author), Bitsch, A. (author), Fisher, C. (author), Graepel, R. (author), Hengstler, J.G. (author), Herzler, M. (author), Knight, D. (author), Leist, M. (author), Norinder, U. (author), Ouédraogo, G. (author), Pastor, M. (author), Stuard, S. (author), White, A. (author), Zdrazil, B. (author), van de Water, B. (author), Kroese, D. (author)
Read-across is one of the most frequently used alternative tools for hazard assessment, in particular for complex endpoints such as repeated dose or developmental and reproductive toxicity. Read-across extrapolates the outcome of a specific toxicological in vivo endpoint from tested (source) compounds to “similar” (target) compound(s). If...
article 2019
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Graepel, R. (author), ter Braak, B. (author), Escher, S.E. (author), Fisher, C. (author), Gardner, I. (author), Kamp, H. (author), Kroese, D. (author), Leist, M. (author), Moné, M.J. (author), Pastor, M. (author), van de Water, B. (author)
The EU-ToxRisk research project is an interdisciplinary research project that aims to advance the paradigm shift in toxicology towards new approach methodology (NAM)–based approaches for risk assessment. In this European research project, experts in the fields of in vitro and in silico techniques and risk assessment from academia, industry and...
article 2019
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Leist, M. (author), Ghallab, A. (author), Graepel, R. (author), Marchan, R. (author), Hassan, R. (author), Bennekou, S.H. (author), Limonciel, A. (author), Vinken, M. (author), Schildknecht, S. (author), Waldmann, T. (author), Danen, E. (author), van Ravenzwaay, B. (author), Kamp, H. (author), Gardner, I. (author), Godoy, P. (author), Bois, F.Y. (author), Braeuning, A. (author), Reif, R. (author), Oesch, F. (author), Drasdo, D. (author), Höhme, S. (author), Schwarz, M. (author), Hartung, T. (author), Braunbeck, T. (author), Beltman, J. (author), Vrieling, H. (author), Sanz, F. (author), Forsby, A. (author), Gadaleta, D. (author), Fisher, C. (author), Kelm, J. (author), Fluri, D. (author), Ecker, G. (author), Zdrazil, B. (author), Terron, A. (author), Jennings, P. (author), van der Burg, B. (author), Dooley, S. (author), Meijer, A.H. (author), Willighagen, E. (author), Martens, M. (author), Evelo, C. (author), Mombelli, E. (author), Taboureau, O. (author), Mantovani, A. (author), Hardy, B. (author), Koch, B. (author), Escher, S. (author), van Thriel, C. (author), Cadenas, C. (author), Kroese, D. (author), van de Water, B. (author), Hengstler, J.G. (author)
Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a formalized, transparent and quality-controlled way, mechanistic information to apical endpoints for regulatory purposes. AOP links a molecular initiating event (MIE) to the adverse outcome (AO) via key events (KE), in a way specified by key event...
article 2017
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Ramirez, T. (author), Daneshian, M. (author), Kamp, H. (author), Bois, F.Y. (author), Clench, M.R. (author), Coen, M. (author), Donley, B. (author), Fischer, S.M. (author), Ekman, D.R. (author), Fabian, E. (author), Guillou, C. (author), Heuer, J. (author), Hogberg, H.T. (author), Jungnickel, H. (author), Keun, H.C. (author), Krennrich, G. (author), Krupp, E. (author), Luch, A. (author), Noor, F. (author), Peter, E. (author), Riefke, B. (author), Seymour, M. (author), Skinner, N. (author), Smirnova, L. (author), Verheij, E. (author), Wagner, S. (author), Hartung, T. (author), van Ravenzwaay, B. (author), Leist, M. (author)
Metabolomics, the comprehensive analysis of metabolites in a biological system, provides detailed information about the biochemical/physiological status of a biological system, and about the changes caused by chemicals. Metabolomics analysis is used in many fields, ranging from the analysis of the physiological status of genetically modified...
article 2013
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Scott, L. (author), Eskes, C. (author), Hoffmann, S. (author), Adriaens, E. (author), Alepée, N. (author), Bufo, M. (author), Clothier, R. (author), Facchini, D. (author), Faller, C. (author), Guest, R. (author), Harbell, J. (author), Hartung, T. (author), Kamp, H. (author), Varlet, B.L. (author), Meloni, M. (author), McNamee, P. (author), Osborne, R. (author), Pape, W. (author), Pfannenbecker, U. (author), Prinsen, M. (author), Seaman, C. (author), Spielmann, H. (author), Stokes, W. (author), Trouba, K. (author), Berghe, C.V.d. (author), Goethem, F.V. (author), Vassallo, M. (author), Vinardell, P. (author), Zuang, V. (author), TNO Kwaliteit van Leven (author)
In spite of over 20 years of effort, no single in vitro assay has been developed and validated as a full regulatory replacement for the Draize Eye Irritation test. However, companies have been using in vitro methods to screen new formulations and in some cases as their primary assessment of eye irritation potential for many years. The present...
article 2010
Searched for: author:"Kamp, H."
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