Searched for: author:"Jie, A.F.H."
(1 - 13 of 13)
document
Rijken, D.C. (author), Hoegee-de Nobel, E. (author), Jie, A.F.H. (author), Atsma, D.E. (author), Schalij, M.J. (author), Nieuwenhuizen, W. (author), TNO Kwaliteit van Leven (author)
Background: The development of global tests for the fibrinolytic capacity in blood is hampered by the low base-line fibrinolytic activity in blood, by the involvement of both plasmatic components and blood cells in the fibrinolytic system and by the loss of fibrinolytic activity as a result of the action of plasminogen activator inhibitor-1 (PAI...
article 2008
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Rijken, D.C. (author), Barrett-Bergshoeff, M.M. (author), Jie, A.F.H. (author), Criscuoli, M. (author), Sakharov, D.V. (author), Gaubius Instituut TNO (author)
Amediplase (K2tu-PA) is a hybrid plasminogen activator, consisting of the kringle 2 domain of alteplase and the protease domain of urokinase. The objective of this study was to determine the in vitro clot penetration of amediplase in relation to its fibrin binding and to compare the properties with those of alteplase. The clot lysis activity of...
article 2004
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Sakharov, D.V. (author), Jie, A.F.H. (author), Filippov, D.V. (author), Bekkers, M.E.A. (author), van Boom, J.H. (author), Rijken, D.C. (author), Gaubius Instituut TNO (author)
Extracellular matrix (ECM) of tissues, vascular tissue in particular, contains a high concentration of negatively charged glycosaminoglycans (GAGs), which are involved in the regulation of cell motility, cell proliferation and the regulation of enzyme activities. Previously, we have shown that the vascular ECM is capable of binding an extremely...
article 2003
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Sakharov, D.V. (author), Jie, A.F.H. (author), Bekkers, M.E.A. (author), Emeis, J.J. (author), Rijken, D.C. (author), Gaubius Instituut TNO (author)
We present the first steps in the elaboration of an approach of extracellular matrix-targeted local drug delivery (ECM-LDD), designed to provide a high concentration, ubiquitous distribution, and long-term retention of a drug within the vessel wall after local intravascular delivery. The approach is based on the concept of a bifunctional drug...
article 2001
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Braat, E.A.M. (author), Jie, A.F.H. (author), Ronday, H.K. (author), Beekman, B. (author), Rijken, D.C. (author), Gaubius Instituut TNO (author)
Background - Excessive fibrin deposition within the inflamed joints of rheumatoid arthritis (RA) patients suggests that local fibrinolysis is inefficient, which seems to be in contrast with the observed increased levels of urokinase type plasminogen activator (u-PA). Thrombin-mediated inactivation of single chain u-PA (scu-PA) into an inactive...
article 2000
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Droog, S. (author), Lakenberg, N. (author), Meulenbelt, I. (author), de Maat, M.P.M. (author), Huisman, L.G.M. (author), Jie, A.F.H. (author), Slagboom, P.E. (author), Gaubius Laboratory TNO Preventie en Gezondheid (author)
For genetic population studies, human genomic DNA is commonly isolated from peripheral blood. A fast, non-invasive DNA sampling method is developed involving oral samples taken with cotton swabs. In addition various procedures were compared for isolation of DNA from different sources: whole blood or buffy-coats stored at -20°C for 5-10 years or...
article 1996
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Rijken, D.C. (author), Jie, A.F.H. (author), Gaubius Laboratory TNO Preventie en Gezondheid (author)
Reteplase is a protein consisting of the kringle-2 and protease domains of tissue-type plasminogen activator (t-PA). Because intravenous heparin will be used as an adjunct to thrombolytic therapy with reteplase, we investigated the interactions in vitro between heparin and reteplase as well as between heparin and recombinant t-PA (alteplase) as...
article 1996
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Kluft, C. (author), Jie, A.F.H. (author), Kooistra, T. (author), de Knijff, P. (author), de Geus, E.J.C. (author), Schaafsma, G. (author), Veenstra, J. (author), Instituut voor toxicologie en voeding Instituut voor verouderings- en vaatziekten onderzoek (author)
bookPart 1992
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Kluft, C. (author), Los, P. (author), Jie, A.F.H. (author), Gaubius instituut TNO (author)
Alpha-2-antiplasmin, a major inhibitor of fibrinolysis, is synthesized in the liver and occurs in blood in two molecular forms: a very active plasminogen-binding (PB) form and a less active nonplasminogen-binding (NPB) form. This study investigated the origin and mutual relationship of these two forms in vivo and in vitro. Despite wide variation...
article 1986
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Kluft, C. (author), Jie, A.F.H. (author), Sprengers, E.D. (author), Verheijen, J.H. (author), Gaubius Instituut TNO (author)
Inhibition of tissue-type plasminogen activator (t-PA) by pooled plasma could be ascribed for only 60% to the endothelial cell type PA inhibitor. The residual inhibition is ascribed to a so-far undescribed plasma component present at 0.2 nmol/l. This component shows reversible binding to t-PA with an apparent K(i) of 10 pmol/l (does not hinder t...
article 1985
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Kluft, C. (author), Verheijen, J.H. (author), Jie, A.F.H. (author), Rijken, D.C. (author), Preston, F.E. (author), Sue-Ling, H.M. (author), Jespersen, J. (author), Aasen, A.O. (author), Gezondheidsorganisatie TNO Gaubius Instituut TNO (author)
The plasma activity level of the recently discovered fast-acting inhibitor of tissue-type plasminogen activator (t-PA) was found to be temporarily increased after surgery, myocardial infarction and severe trauma. Detailed analysis of the postoperative period revealed simultaneously increased t-PA antigen and inhibition and decreased t-PA...
article 1985
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Kluft, C. (author), Traas, D.W. (author), Jie, A.F.H. (author), Hoegee de Nobel, E. (author), Gaubius instituut TNO (author)
Various plasmin preparations were tested for their suitability for use in the assay of ??2-antiplasmin in blood plasma by the immediate plasmin inhibition test. Activation of plasminogen, viz., 1-Glu-plasminogen and/or 77-Lys-plasminogen, by immobilized urokinase results in plasmin preparations suitable for this ??2-antiplasmin test. Plasmins...
article 1982
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Kluft, C. (author), Trumpi-Kalshoven, M.M. (author), Jie, A.F.H. (author), Veldhuyzen-Stolk, E.C. (author), Gaubius instituut TNO (author)
Fibrinolytic studies in euglobulin fractions of Fletcher trait plasma (deficient in prekallikrein) revealed reduced activities as compared to normal plasma. A quantitative assay for total plasminogen activator plus proactivator in plasma showed that the amount in Fletcher trait patients is about half of normal (normal = ?? 100 blood activator...
article 1979
Searched for: author:"Jie, A.F.H."
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