Searched for: author:"Jespersen, J."
(1 - 20 of 20)
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de Maat, M.P.M. (author), Dooijewaard, G. (author), Meijer, P. (author), Binder, B.R. (author), Keber, D. (author), Risberg, B. (author), Kluft, C. (author), Jespersen, J. (author), Gaubius Instituut TNO (author)
In most Westernized societies cardiovascular diseases are the leading cause of death over the age of 45 years and one-quarter of these deaths occur in men below the age of 65 years. The haemostasis system has been identified as an important system in cardiovascular disease (CVD). The European Concerted Action on Prevention from Thrombosis by...
article 2001
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Kluft, C. (author), Meijer, P. (author), Gram, J. (author), Jespersen, J. (author), Gaubius instituut TNO (author)
article 1999
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Myrup, B. (author), Rossing, P. (author), Jensen, T. (author), Gram, J. (author), Kluft, C. (author), Jespersen, J. (author), Gaubius instituut TNO (author)
Objective: To investigate protein concentration changes during venous occlusion of proteins with reported affinity for extracellular matrix (plasminogen activator inhibitor type 1, antithrombin III, fibronectin and von Willebrand factor) in comparison with proteins with no reported affinity (albumin, tissue-type plasminogen activator,...
article 1999
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Kluft, C. (author), Meijer, P. (author), Gram, J. (author), Jespersen, J. (author), Sidelmann, J. (author), te Koppele, J.M. (author), Buytenhek, M. (author), Gaubius Instituut TNO (author)
conference paper 1999
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Dooijewaard, G.D. (author), Maat Mpm, E. (author), Meijer, P. (author), Kluft, C. (author), Binder, B.R. (author), Jespersen, J. (author), Keber, D. (author), Risberg, B. (author), Gaubius Instituut TNO (author)
Introduction. This study addresses the rote of circulatory u-PA in the prevention and precipitation of arterial thrombosis. u-PA occurs in three forms: the inactive zymogen scu-PA, the active enzyme tcu-PA and u-PA#, the inactive complex of tcu-PA with inhibitors. In apparently healthy individuals (n=50) scu-PA amounts 2.2±0.4 ng/ml, u-PA# 1.1 ...
article 1998
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Myrup, B. (author), Jensen, T. (author), Gram, J. (author), Kluft, C. (author), Jespersen, J. (author), Deckert, T. (author), Gaubius Instituut TNO (author)
OBJECTIVE - The high risk for cardiovascular disease in IDDM patients with nephropathy may be mediated by abnormal function of the vascular wall. We investigated whether heparin was able to modulate markers of vascular wall and hemostatic function in patients with incipient nephropathy. RESEARCH DESIGN AND METHODS - Thirty-five IDDM patients...
article 1997
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de Maat, M.P.M. (author), Green, F. (author), de Knijff, P. (author), Jespersen, J. (author), Kluft, C. (author), Gaubius Instituut TNO (author)
Increased plasma factor VII coagulant activity (FVII:C) has been associated with the risk of ischemic heart disease (IHD). Differences in plasma FVII:C among individuals are associated with three common polymorphisms in the FVII gene. Therefore, we investigated FVII polymorphisms in four populations that differ in their risk of developing...
article 1997
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Juhan-Vague, I. (author), Pyke, S.D.M. (author), Alessi, M.C. (author), Jespersen, J. (author), Haverkate, F. (author), Thompson, S.G. (author), Hematology Laboratory, CHU Timone, Marseille, France Medical Statistics Unit, London (UK) Sch. of Hyg./Trop. Med. Centralsygehuset, Esbjerg, Denmark Gaubius Laboratory Hematology Laboratory, CHU Timone, 13385 Marseille Cedex 5, France TNO Preventie en Gezondheid (author)
Background: Disturbances of the fibrinolytic system that lead to decreased removal of fibrin deposits may be important risk factors for coronary thrombosis. There is as yet no consensus on the prognostic value of fibrinolytic parameters, which may be attributed in part to the choice of confounding variables controlled for. Methods and Results:...
article 1996
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Gram, J. (author), Jespersen, J. (author), Kluft, C. (author), Declerck, P. (author), Gaubius Instituut TNO (author)
Biochemical measurements of quantities, i.e. analytes, of the haemostatic system are the basis of evaluating patients with potentially serious or lifethreatening disorders. Therefore, there is a need of a high level of certainty of the results. Experience based on the comprehensive international standardization of prothrombin time measurements ...
article 1996
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de Maat, M.P.M. (author), de Knijff, P. (author), Green, F.R. (author), Thomas, A.E. (author), Jespersen, J. (author), Kluft, C. (author), TNO Preventie en Gezondheid (author)
Elevated plasma fibrinogen levels represent an increased risk for cardiovascular diseased, but the mechanism explaining this association is still not clear. Genetic differences may play a role, because it has been shown that individuals who carry the rare alleles of polymorphisms in the genes for the Bβ-chain (Bcl I and G/A 455) and the Aα-chain...
article 1995
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Myrup, B. (author), Hansen, P.M. (author), Jensen, T. (author), Kofoed-Enevoldsen, A. (author), Feldt-Rasmussen, B. (author), Gram, J. (author), Kluft, C. (author), Jespersen, J. (author), Deckert, T. (author), Gaubius Instituut TNO (author)
We investigated the effect of heparin on urinary albumin excretion in patients with insulin-dependent diabetes mellitus. 39 patients with persistent urinary albumin excretion of 30-300 mg/24 h were randomly treated for 3 months with subcutaneous injections twice daily of isotonic saline, 5000 IU unfractionated heparin, or 2000 anti-Xa IU low...
article 1995
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Gram, J.B. (author), Leebeek, F.W.G. (author), Kluft, C. (author), Jespersen, J. (author), TNO Preventie en Gezondheid (author)
article 1994
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Myrup, B. (author), Rossing, P. (author), Jonson, T. (author), Gram, J. (author), Kluft, C. (author), Jespersen, J. (author), Gaubius instituut (author)
Supplement with abstract from the 29th Annual Meeting of the European Association for the Study of Diabetes Istanbul, Turkey 6-10 September 1993
article 1993
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Gram, J. (author), Munkvad, S. (author), Leebeek, F.W.G. (author), Kluft, C. (author), Jespersen, J. (author), Gaubius instituut Instituut voor verouderings- en vaatziekten onderzoek TNO (author)
Background: We and others have demonstrated that administration of thrombolytic agents causes the generation of thrombosis-promoting agents. At present, we have studied whether formation in vivo of excessive amounts of plasmin is responsible for the activation of coagulation in patients treated with recombinant tissue-type plasminogen activator....
article 1993
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Jespersen, J. (author), Gaubius instituut (author)
article 1992
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Jespersen, J. (author), Gaubius instituut (author)
Panel discussion
article 1992
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Jespersen, J. (author), Gaubius instituut (author)
other 1992
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Munkvad, S. (author), Nieuwenhuizen, W. (author), Jespersen, J. (author), Gezondheidsorganisatie TNO Gaubius Instituut TNO (author)
article 1990
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Kluft, C. (author), Verheijen, J.H. (author), Jie, A.F.H. (author), Rijken, D.C. (author), Preston, F.E. (author), Sue-Ling, H.M. (author), Jespersen, J. (author), Aasen, A.O. (author), Gezondheidsorganisatie TNO Gaubius Instituut TNO (author)
The plasma activity level of the recently discovered fast-acting inhibitor of tissue-type plasminogen activator (t-PA) was found to be temporarily increased after surgery, myocardial infarction and severe trauma. Detailed analysis of the postoperative period revealed simultaneously increased t-PA antigen and inhibition and decreased t-PA...
article 1985
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Jespersen, J. (author), Kluft, C. (author), Gezondheidsorganisatie TNO Gaubius Instituut TNO (author)
Histidine-rich glycoprotein (HRG), a 3.8 S-αc2-glycoprotein recently identified as a new flbrinolysis regulating protein, was determined by an electroimmunoassay in samples of plasma collected during one menstrual or hormone cycle in 15 young women and in 11 women using oral contraceptives with 30 μg ethinyl oestradiol and 150 μg levo-norgestrel...
article 1982
Searched for: author:"Jespersen, J."
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