Searched for: author%3A%22Jenniskens%2C+Y.M.%22
(1 - 15 of 15)
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Wei, W. (author), Bastiaanen-Jenniskens, Y.M. (author), Suijkerbuik, M. (author), Kops, N. (author), Bos, P.K. (author), Verhaar, J.A.M. (author), Zuurmond, A.M. (author), Dell'Accio, F. (author), van Osch, G.J.V.M. (author)
Obesity is a well-known risk factor for osteoarthritis, but it is unknown what it does on cartilage repair. Here we investigated whether a high fat diet (HFD) influences cartilage repair in a mouse model of cartilage repair. We fed DBA/1 mice control or HFD (60% energy from fat). After 2 weeks, a full thickness cartilage defect was made in the...
article 2017
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de Jong, A.J. (author), Klein-Wietinga, I.R. (author), Andersen, S.N. (author), Kwekkeboom, J.C. (author), Herb-van Toorn, L. (author), de Lange-Brokaar, B.J.E. (author), van Delft, D. (author), Garcia, J. (author), Wei, W. (author), van der Heide, H.J.L. (author), Bastiaanen-Jenniskens, Y.M. (author), van Osch, G.J.V.M. (author), Zuurmond, A.M. (author), Stojanovic-Susulic, V. (author), Nelissen, R.G. (author), Toes, R.E.M. (author), Kloppenburg, M. (author), Ioan-Facsinay, A. (author)
Background. Obesity is associated with the development and progression of osteoarthritis (OA). Although the infrapatellar fat pad (IFP) could be involved in this association, due to its intracapsular localization in the knee joint, there is currently little known about the effect of obesity on the IFP. Therefore, we investigated cellular and...
article 2017
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Wei, W. (author), Clockaerts, S. (author), Bastiaansen-Jenniskens, Y.M. (author), Gierman, L.M. (author), Botter, S.M. (author), Bierma-Zeinstra, S.M.A. (author), Weinans, H. (author), Verhaar, J.A.N. (author), Kloppenburg, M. (author), Zuurmond, A.M. (author), van Osch, G.J.V.M. (author)
Objective: Since statins and fibrates are capable of improving the metabolic profile of patients as well as decreasing inflammation, they are considered as potential drugs for preventing osteoarthritis (OA). The goal of the present study was to investigate the effect of these drugs in the STR/Ort spontaneous OA mouse model. Design: Male STR/Ort...
article 2014
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Gierman, L.M. (author), Wopereis, S. (author), van El, B. (author), Verheij, E.R. (author), Werff-Van Der Vat, B.J.C. (author), Bastiaansen-Jenniskens, Y.M. (author), van Osch, G.J.V.M. (author), Kloppenburg, M. (author), Stojanovic-Susulic, V. (author), Huizinga, T.W.J. (author), Zuurmond, A.M. (author)
Objective The infrapatellar fat pad (IPFP) in the knee joint is hypothesized to contribute to osteoarthritis (OA) development by the IFPF possibly by influencing inflammatory processes. Oxylipins are essential mediators in the inflammatory process. We undertook this study to investigate secretion by the IFPF of fatty acids and oxylipins derived...
article 2013
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Bastiaansen-Jenniskens, Y.M. (author), Siawash, M. (author), van de Lest, C.H.A. (author), Verhaar, J.A.N. (author), Kloppenburg, M. (author), Zuurmond, A.M. (author), Stojanovic-Susulic, V. (author), van Osch, G.J.V.M. (author), Clockaerts, S. (author)
Purpose: Osteoarthritis (OA) is associated with obesity in which altered fatty acid levels have been observed. We investigated whether the most common fatty acids in synovial fluid influence cartilage deterioration in OA. Design: Cartilage was obtained from OA patients undergoing total knee arthroplasty. Chondrocytes or cartilage explants were...
article 2013
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Bastiaansen-Jenniskens, Y.M. (author), Wei, W. (author), Feijt, C. (author), Waarsing, J.H. (author), Verhaar, J.A. (author), Zuurmond, A.M. (author), Hanemaaijer, R. (author), Stoop, R. (author), van Osch, G.J. (author)
Objective: Stiffening of the joint is a feature of knee osteoarthritis (OA) that can be caused by fibrosis of the synovium. The infrapatellar fat pad (IPFP) present in the knee joint produces immune-modulatory and angiogenic factors. The goal of the present study was to investigate whether the IPFP can influence fibrotic processes in synovial...
article 2013
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Bastiaansen-Jenniskens, Y.M. (author), Clockaerts, S. (author), Feijt, C. (author), Zuurmond, A.M. (author), Stojanovic-Susulic, V. (author), Bridts, C. (author), de Clerck, L. (author), de Groot, J. (author), Verhaar, J.A.N. (author), Kloppenburg, M. (author), van Osch, G.J.V.M. (author)
Objective: Adipose tissue is known to release inflammatory cytokines and growth factors. In this exploratory study, the authors examined whether the infrapatellar fat pad (IPFP) closely located to cartilage in the knee joint can affect cartilage metabolism. In addition, the authors analysed whether the macrophage types present in IPFP could...
article 2012
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Clockaerts, S. (author), Bastiaansen-Jenniskens, Y.M. (author), Feijt, C. (author), Clerck, L.de (author), Verhaar, J.A.N. (author), Zuurmond, A.M. (author), Stojanovic-Susulic, V. (author), Somville, J. (author), Kloppenburg, M. (author), van Osch, G.J.V.M. (author)
Background: Infrapatellar fat pad (IPFP) might be involved in osteoarthritis (OA) by production of cytokines. It was hypothesised that production of cytokines is sensitive to environmental conditions. Objectives: To evaluate cytokine production by IPFP in response to interleukin (IL)1β and investigate the ability to modulate this response with...
article 2012
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Klein-Wieringa, I.R. (author), Kloppenburg, M. (author), Bastiaansen-Jenniskens, Y.M. (author), Yusuf, E. (author), Kwekkeboom, J.C. (author), El-Bannoudi, H. (author), Nelissen, R.G.H.H. (author), Zuurmond, A. (author), Stojanovic-Susulic, V. (author), van Osch, G.J.V.M. (author), Toes, R.E.M. (author), Ioan-Facsinay, A. (author)
Objectives: Obesity is a risk factor for the development of osteoarthritis (OA) in hands and knees. Adipose tissue can secrete different adipokines with powerful immunomodulatory effects. The infrapatellar fat pad (IFP) is an intra-articular organ in the vicinity of the synovium and cartilage. It is hypothesised that IFP-derived soluble factors...
article 2011
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Blumbach, K. (author), Bastiaansen-Jenniskens, Y.M. (author), de Groot, J. (author), Paulsson, M. (author), van Osch, G.J.V.M. (author), Zaucke, F. (author), TNO Kwaliteit van Leven (author)
Objective. Defects in the assembly and composition of cartilage extracellular matrix are likely to result in impaired matrix integrity and increased susceptibility to cartilage degeneration. The aim of this study was to determine the functional interaction of the collagen fibril-associated proteins type IX collagen and cartilage oligomeric...
article 2009
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Bastiaansen-Jenniskens, Y.M. (author), Koevoet, W. (author), Jansen, K.M.B. (author), Verhaar, J.A.N. (author), de Groot, J. (author), Vanosch, G.J.V.M. (author), TNO Kwaliteit van Leven (author)
To understand cartilage degenerative diseases and improve repair procedures, we investigate the influence of glycosaminoglycans (GAGs) on cartilage matrix biochemistry and functionality. Bovine articular chondrocytes were cultured in alginate beads with(out) para-nitrophenyl-beta-d-xyloside (PNPX) to inhibit GAG incorporation into newly formed...
article 2009
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Bastiaansen-Jenniskens, Y.M. (author), Koevoet, W. (author), de Bart, A.C.W. (author), van der Linden, J.C. (author), Zuurmond, A.M. (author), Weinans, H. (author), Verhaar, J.A.N. (author), van Osch, G.J.V.M. (author), de Groot, J. (author), TNO Kwaliteit van Leven (author)
Background: Damage to articular cartilage is one of the features of osteoarthritis (OA). Cartilage damage is characterised by a net loss of collagen and proteoglycans. The collagen network is considered highly important for cartilage function but little is known about processes that control composition and function of the cartilage collagen...
article 2008
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TNO Kwaliteit van Leven (author), Bastiaansen-Jenniskens, Y.M. (author), Koevoet, W. (author), de Bart, A.C.W. (author), Zuurmond, A.M. (author), Bank, R.A. (author), Verhaar, J.A.N. (author), de Groot, J. (author), van Osch, G.J.V.M. (author)
Transforming growth factor beta (TGFbeta) is often used in cartilage tissue engineering to increase matrix formation by cells with various phenotypes. However, adverse effects of TGFbeta, such as extensive cross-linking in cultured fibroblasts, have also been reported. Our goal was to study effects of TGFbeta on collagen cross-linking and...
article 2008
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Jenniskens, Y.M. (author), Koevoet, W. (author), de Bart, A.C.W. (author), Weinans, H. (author), Jahr, H. (author), Verhaar, J.A.N. (author), de Groot, J. (author), van Osch, G.J.V.M. (author), TNO Kwaliteit van Leven (author)
Objective: Examine effects of insulin-like growth factor 1 (IGF1), transforming growth factor β2 (TGFβ2) and fibroblast growth factor 2 (FGF2) on proteoglycan and collagen network and biomechanical properties of the newly formed cartilage matrix. Methods: Bovine articular chondrocytes were cultured in alginate beads for 3 weeks with or without...
article 2006
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TNO Kwaliteit van Leven (author), Uitterlinden, E.J. (author), Jahr, H. (author), Koevoet, J.L.M. (author), Jenniskens, Y.M. (author), Bierma-Zeinstra, S.M.A. (author), de Groot, J. (author), Verhaar, J.A.N. (author), Weinans, H. (author), van Osch, G.J.V.M. (author)
Objective: To investigate the effect of glucosamine (GlcN) in a human osteoarthritic explant model on expression of genes involved in anabolic and catabolic activities of chondrocytes. Methods: Human osteoarthritic explants, obtained during knee arthroplasty surgery, were pre-cultured (3 days) and treated with glucosamine-hydrochloride (GlcN-HCl...
article 2006
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