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Jacobs, P.L. (author), Ridder, L. (author), Ruijken, M. (author), Rosing, H. (author), Jager, N.G.L. (author), Beijnen, J.H. (author), Bas, R.R. (author), van Dongen, W.D. (author), TNO Triskelion BV (author)
Background: Comprehensive identification of human drug metabolites in first-in-man studies is crucial to avoid delays in later stages of drug development. We developed an efficient workflow for systematic identification of human metabolites in plasma or serum that combines metabolite prediction, high-resolution accurate mass LC-MS and MS vendor...
article 2013