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Prenatal exposure to nonpersistent chemical mixtures and fetal growth: A population-based study

van den Dries, M.A. (author), Keill, A.P. (author), Tiemeier, H. (author), Pronk, A. (author), Spaan, S. (author), Santos, S. (author), Asimakopoulos, A.G. (author), Kannan, K. (author), Gaillard, R. (author), Guxens, M. (author), Trasande, L. (author), Jaddoe, V.W.V. (author), Ferguson, K.K. (author)

BACKGROUND: Prenatal exposure to mixtures of nonpersistent chemicals is universal. Most studies examining these chemicals in association with fetal growth have been restricted to single exposure models, ignoring their potentially cumulative impact. OBJECTIVE: We aimed to assess the association between prenatal exposure to a mixture of phthalates...

article 2021

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Prenatal Exposure to Nonpersistent Chemical Mixtures and Offspring IQ and Emotional and Behavioral Problems

van den Dries, M.A. (author), Ferguson, K.K. (author), Keill, A.P. (author), Pronk, A. (author), Spaan, S. (author), Ghassabian, A. (author), Santos, S. (author), Jaddoe, V.W.V. (author), Trasande, L. (author), Tiemeier, H. (author), Guxens, M. (author)

Prenatal exposure to nonpersistent chemicals such as phthalates, bisphenols, and organophosphate (OP) pesticides is ubiquitous and occurs in mixtures. So far, epidemiological studies investigating neurodevelopmental consequences of these exposures have mainly been restricted to single-pollutant models. Thus, we studied the association between...

article 2021

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Fetal Growth Trajectories among Small for Gestational Age Babies and Child Neurodevelopment

Ferguson, K.K. (author), Sammallahti, S. (author), Rosen, E. (author), van den Dries, M. (author), Pronk, A. (author), Spaan, S. (author), Guxens, M. (author), Tiemeier, H. (author), Gaillard, R. (author), Jaddoe, V.W.V. (author)

Background: Being born small for gestational age (SGA,

article 2021

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Phthalate and bisphenol exposure during pregnancy and offspring nonverbal IQ

van den Dries, M.A. (author), Guxens, M. (author), Spaan, S. (author), Ferguson, K.K. (author), Philips, E. (author), Santos, S. (author), Jaddoe, V.W.V. (author), Ghassabian, A. (author), Trasande, L. (author), Tiemeier, H. (author), Pronk, A. (author)

BACKGROUND: Prenatal exposures to phthalates and bisphenols are associated with impaired brain development in animals. However, epidemiological studies investigating the association between prenatal phthalate or bisphenol exposure and cognition have produced mixed findings and mostly had modest sample sizes and measured the exposure during the...

article 2020

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Organophosphate pesticide exposure in pregnancy in association with ultrasound and delivery measures of fetal growth

Ferguson, K.K. (author), van den Drie, M.A. (author), Gaillar, R. (author), Pron, A. (author), Spaa, S. (author), Tiemeie, H. (author), Jaddoe, V.W.V. (author)

Background: Perturbations in fetal growth may have adverse consequences for childhood and later life health. Organophosphate pesticide (OP) exposure has been associated with reduced birth weight at delivery but results are not consistent. We investigated this question by utilizing ultrasound measures of size in utero in combination with measures...

article 2019

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Gestational weight gain charts for different body mass index groups for women in Europe, North America, and Oceania

Santos, S. (author), Eekhout, I. (author), Voerman, E. (author), Gaillard, R. (author), Barros, H. (author), Charles, M.A. (author), Chatzi, L. (author), Chevrier, C. (author), Chrousos, G.P. (author), Corpeleijn, E. (author), Costet, N. (author), Crozier, S. (author), Doyon, M. (author), Eggesbø, M. (author), Fantini, M.P. (author), Farchi, S. (author), Francesco Forastiere, F. (author), Gagliardi, L. (author), Georgiu, V. (author), Godfrey, K.M. (author), Gori, D. (author), Grote, V. (author), Hanke, W. (author), Hertz-Picciotto, I. (author), Heude, B. (author), Hivert, M.F. (author), Hryhorczuk, D. (author), Huang, R.C. (author), Inskip, H. (author), Jusko, T.A. (author), Karvonen, A.M. (author), Koletzko, B. (author), Küpers, L.K. (author), Lagström, H. (author), Lawlor, D.A. (author), Lehmann, I. (author), Lopez-Espinosa, M.J. (author), Magnus, P. (author), Majewska, R. (author), Mäkelä, J. (author), Manios, Y. (author), McDonald, S.W. (author), Mommers, M. (author), Morgen, C.S. (author), Moschonis, G. (author), Murínová, L. (author), Newnham, J. (author), Nohr, E.A. (author), Nybo Andersen, A.M. (author), Oken, E. (author), Oostvogels, A.J.J.M. (author), Pac, A. (author), Papadopoulou, E. (author), Pekkanen, J. (author), Pizzi, C. (author), Polanska, K. (author), Porta, D. (author), Richiardi, L. (author), Rifas-Shiman, S.L. (author), Roeleveld, N. (author), Santa-Marina, L. (author), Santos, A.C. (author), Smit, H.A. (author), Sørensen, T.I.A. (author), Standl, M. (author), Stanislawski, M. (author), Stoltenberg, C. (author), Thiering, E. (author), Thijs, C. (author), Torrent, M. (author), Tough, S.C. (author), Trnovec, T. (author), van Gelder, M.M.H.J. (author), van Rossem, L. (author), von Berg, A. (author), Vrijheid, M. (author), Vrijkotte, T.G.M. (author), Zvinchuk, O. (author), van Buuren, S. (author), Jaddoe, V.W.V. (author)

Background. Gestational weight gain differs according to pre-pregnancy body mass index and is related to the risks of adverse maternal and child health outcomes. Gestational weight gain charts for women in different pre-pregnancy body mass index groups enable identification of women and offspring at risk for adverse health outcomes. We aimed to...

article 2018

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Reproducibility of urinary bisphenol A concentrations measured during pregnancy in the Generation R Study

Jusko, T.A. (author), Shaw, P.A. (author), Snijder, C.A. (author), Pierik, F.H. (author), Koch, H.M. (author), Hauser, R. (author), Jaddoe, V.W.V. (author), Burdorf, A. (author), Hofman, A. (author), Tiemeier, H. (author), Longnecker, M.P. (author)

The potential human health effects of bisphenol A (BPA) exposure are a public health concern. In order to design adequately powered epidemiological studies to address potential health effects, data on the reproducibility of BPA concentration in seri al urine specimens taken during pregnancy are needed. To provide additional data on the...

article 2014

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The impact of preschool wheezing patterns on health-related quality of life at age 4 years pattern of pulmonary adenocarcinoma

Hafkamp-De Groen, E. (author), Mohangoo, A.D. (author), Landgraf, J.M. (author), de Jongste, J.C. (author), Duijts, L. (author), Moll, H.A. (author), Jaddoe, V.W.V. (author), Hofmane, A. (author), Raat, H. (author)

We assessed whether dynamic preschool wheezing patterns affect health-related quality of life (HRQOL) at age 4 years. The study included 3878 children participating a prospective cohort study. Information on preschool wheezing was obtained by questionnaire and children were categorised into: never, early, late and persistent wheezing. At age 4...

article 2013

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Preschool physical activity and functional constipation: The generation r study

Driessen, L.M. (author), Jong, J.C.K.D. (author), Wijtzes, A. (author), de Vries, S.I. (author), Jaddoe, V.W.V. (author), Hofman, A. (author), Raat, H. (author), Moll, H.A. (author)

OBJECTIVES:: Decreased physical activity levels in children may partly explain the rising prevalence of functional constipation in childhood. The aim of the present study, therefore, was to examine the association between physical activity and functional constipation during the preschool period. METHODS:: This study was embedded in the...

article 2013

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Correlates of physical activity in 2-year-old toddlers: The generation R study

Wijtzes, A.I. (author), Kooijman, M.N. (author), Kiefte-de Jong, J.C. (author), de Vries, S.I. (author), Henrichs, J. (author), Jansen, W. (author), Jaddoe, V.W.V. (author), Hofman, A. (author), Moll, H.A. (author), Raat, H. (author)

Objective: To describe and identify correlates of objectively measured physical activity and sedentary behavior in 2-year-old toddlers. Study design: A total of 347 children participating in a birth cohort study wore a unaxial ActiGraph accelerometer during 1 weekday and 1 weekend day. Information on potential correlates was assessed by parent...

article 2013

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Air pollution exposure during pregnancy, ultrasound measures of fetal growth, and adverse birth outcomes: A prospective cohort study

van den Hooven, E.H. (author), Pierik, F.H. (author), de Kluizenaar, Y. (author), Willemsen, S.P. (author), Hofman, A. (author), van Ratingen, S.W. (author), Zandveld, P.Y.J. (author), Mackenbach, J.P. (author), Steegers, E.A.P. (author), Miedema, H.M.E. (author), Jaddoe, V.W.V. (author)

Background: Air pollution exposure during pregnancy might have trimester-specific effects on fetal growth. Objective: We prospectively evaluated the associations of maternal air pollution exposure with fetal growth characteristics and adverse birth outcomes in 7,772 subjects in the Netherlands. Methods: Particulate matter with an aerodynamic...

article 2012

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Chronic air pollution exposure during pregnancy and maternal and fetal c-reactive protein levels: The generation R study

van den Hooven, E.H. (author), de Kluizenaar, Y. (author), Pierik, F.H. (author), Hofman, A. (author), van Ratingen, S.W. (author), Zandveld, P.Y.J. (author), Lindemans, J. (author), Russcher, H. (author), Steegers, E.A.P. (author), Miedema, H.M.E. (author), Jaddoe, V.W.V. (author)

Background: Exposure to air pollution has been associated with higher C-reactive protein (CRP) levels, suggesting an inflammatory response. Not much is known about this association in pregnancy. Objectives: We investigated the associations of air pollution exposure during pregnancy with maternal and fetal CRP levels in a population-based cohort...

article 2012

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The role of prenatal, perinatal and postnatal factors in the explanation of socioeconomic inequalities in preschool asthma symptoms: The generation R study

Hafkamp-de Groen, E. (author), van Rossem, L. (author), de Jongste, J.C. (author), Mohangoo, A.D. (author), Moll, H.A. (author), Jaddoe, V.W.V. (author), Hofman, A. (author), Mackenbach, J.P. (author), Raat, H. (author)

Background The authors assessed whether socioeconomic inequalities in asthma symptoms were already present in preschool children and to what extent prenatal, perinatal and postnatal risk factors for asthma symptoms mediate the effect of socioeconomic status (SES). Methods The study included 3136 Dutch children participating in the Generation R...

article 2012

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Air Pollution Exposure and Markers of Placental Growth and Function: The Generation R Study

van den Hooven, E.H. (author), Pierik, F.H. (author), de Kluizenaar, Y. (author), Hofman, A. (author), van Ratingen, S.W. (author), Zandveld, P.Y.J. (author), Russcher, H. (author), Lindemans, J. (author), Miedema, H.M.E. (author), Steegers, E.A.P. (author), Jaddoe, V.W.V. (author)

article 2012

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Asthma-like symptoms in the first year of life and health-related quality of life at age 12 months: The Generation R study

Mohangoo, A.D. (author), de Koning, H.J. (author), de Jongste, J.C. (author), Landgraf, J.M. (author), van der Wouden, J.C. (author), Jaddoe, V.W.V. (author), Hofman, A. (author), Moll, H.A. (author), Mackenbach, J.P. (author), Raat, H. (author)

Purpose: This study compares HRQOL among subgroups of infants with asthma-like symptoms to a subgroup without such symptoms and examines independent associations between asthma-like symptoms during the first year of life and HRQOL at age 12 months. Methods: Our study sample included 5,000 infants participating in the Generation R study. Their...

article 2012

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Air Pollution Exposure During Pregnancy, Ultrasound Measures of Fetal Growth, and Adverse Birth Outcomes: A Prospective Cohort Study

van den Hooven, E.H. (author), Pierik, F.H. (author), de Kluizenaar, Y. (author), Willemsen, S.P. (author), Hofman, A. (author), van Ratingen, S.W. (author), Zandveld, P.Y.J. (author), Mackenbach, J.P. (author), Steegers, E.A.P. (author), Miedema, H.M.E. (author), Jaddoe, V.W.V. (author)

article 2011

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Air Pollution Exposure During Pregnancy, Ultrasound Measures of Fetal Growth, and Adverse Birth Outcomes: A Prospective Cohort Study : Supplemental Material

van den Hooven, E.H. (author), Pierik, F.H. (author), de Kluizenaar, Y. (author), Willemsen, S.P. (author), Hofman, A. (author), van Ratingen, S.W. (author), Zandveld, P.Y.J. (author), Mackenbach, J.P. (author), Steegers, E.A.P. (author), Miedema, H.M.E. (author), Jaddoe, V.W.V. (author)

conference paper 2011

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Air pollution, blood pressure, and the risk of hypertensive complications during pregnancy: The generation r study

van den Hooven, E.H. (author), de Kluizenaar, Y. (author), Pierik, F.H. (author), Hofman, A. (author), van Ratingen, S.W. (author), Zandveld, P.Y.J. (author), MacKenbach, J.P. (author), Steegers, E.A.P. (author), Miedema, H.M.E. (author), Jaddoe, V.W.V. (author)

Exposure to air pollution is associated with elevated blood pressure and cardiovascular disease. We assessed the associations of exposure to particulate matter (PM10) and nitrogen dioxide (NO2) levels with blood pressure measured in each trimester of pregnancy and the risks of pregnancy-induced hypertension and preeclampsia in 7006 women...

article 2011

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A comparison of parent-reported wheezing or shortness of breath among infants as assessed by questionnaire and physician-interview: The generation R study

Mohangoo, A.D. (author), de Koning, H.J. (author), Groen, E.H.D. (author), van der Wouden, J.C. (author), Jaddoe, V.W.V. (author), Moll, H.A. (author), Hofman, A. (author), Mackenbach, J.P. (author), de Jongste, J.C. (author), Raat, H. (author), TNO Kwaliteit van Leven (author)

Purpose: The prevalence of asthma symptoms among preschool children is difficult to determine with accuracy because no gold standard is available for diagnosis. The aim of this study was to compare parent-reported wheezing or shortness of breath among infants as assessed by questionnaire and physician-interview. Methods: We studied 1,202...

article 2010

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Levels of metabolites of organophosphate pesticides, phthalates, and bisphenol A in pooled urine specimens from pregnant women participating in the Norwegian Mother and Child Cohort Study (MoBa)

Ye, X. (author), Pierik, F.H. (author), Angerer, J. (author), Meltzer, H.M. (author), Jaddoe, V.W.V. (author), Tiemeier, H. (author), Hoppin, J.A. (author), Longnecker, M.P. (author), TNO Bouw en Ondergrond (author)

Concerns about reproductive and developmental health risks of exposure to organophosphate (OP) pesticides, phthalates, and bisphenol A (BPA) among the general population are increasing. Six dialkyl phosphate (DAP) metabolites, 3,5,6-trichloro-2-pyridinol (TCPy), BPA, and fourteen phthalate metabolites were measured in 10 pooled urine samples...

article 2009