Cell culture techniques in biotransformation studies

Pharmacokinetic differences of desmethyldiazepam in three outbred Wistar strains related to differences in liver enzyme activities

Various strains of rats differ in their sensitivities towards benzodiazepines suggesting that variations in biological features are responsible for these differences. All reports concern inbred strains. We have studied male rats of three outbred Wistar strains with regard to the pharmacokinetics of desmethyldiazepam given as a single intravenous...

The role of oxidative metabolism in hexachlorobenzene-induced porphyria and thyroid hormone homeostasis: a comparison with pentachlorobenzene in a 13-week feeding study

Hexachlorobenzene (HCB) induces a broad spectrum of effects including disturbances in the heme synthesis (porphyria) and in thyroid hormone homeostasis. For most of its effects, biotransformation of the parent compound seems to be a prerequisite. The present study was designed to assess the relevance of the oxidative metabolites in HCB-induced...

Food and nutrition policy in Europe: proceedings of the Second European Conference on Food and Nutrition Policy, The Hague, 21-24 April 1992

Tannins in faba beans (Vicia faba L.): antinutritional properties in monogastric animals

Condensed tannins are found in coloured-flowering varieties of faba beans ( Viciafaba L.). They are considered as antinutritional factors for nonruminant species. High-tannin hulls of faba beans and isolated tannins were shown to induce a rapid hypertrophy of the parotid glands in rats and increase the secretion of salivary proline-rich proteins...

Assessment of variety, clustering and adequacy of eating patterns: Dutch National Food Consumption Survey

Nutrition: Health aspects of meat consumption

Effect of long-term ethanol administration on survival and age-related pathophysiologicaal changes in calorie restricted rats

Susceptibility of the respiratory tract to toxic substances

Vitamin B-6 supplementation in elderly men: Effects on mood, memory, performance and mental effort

Acid reaction products of indole-3-carbinol and their effects on cytochrome P450 and phase II enzymes in rat and monkey hepatocytes

The effects of three acid condensation products of indole-3-carbinol (I3C), i.e. 3,3'-diindolylmethane (DIM), 5,6,11,12,17,18-hexahydrocyclonona[1,2-b:4,5-b:7,8-b]tri-indole (CTI) and 2,3-bis[3-indolylmethyl]indole (BII), on cytochrome P450 and phase II enzymes were studied in primary cultures of rat and cynomolgus monkey liver cells. In rat...

Marginal deficiencies of thiamin, riboflavin, vitamin B-6 and vitamin C: prevalence and functional consequences in man

The validity of total diet studies for assessing nutrient intake

Vormgeven: verslag van de NRLO-themadag gehouden op 15 mei 1991 te Wageningen

Mechanical properties of the respiratory system, a study in humans and rats by forced oscillations

Moderate alcohol consumption and risk of coronary heart disease, an experimental approach

The use of liver cell cultures derived from different mammalian species in in vitro toxicological studies: implementation in extrapolation models?

In vitro techniques can be applied to obtain insight into the organotoxic potential of compounds and in the underlying mechanisms of action. During the last few decades the applicability of these techniques in toxicology has been demonstrated for an increasing number of cell types. Cultured hepatocytes have been shown to provide convenient in...