document

Correlation between the antibody response to influenza vaccine and helper T cell subsets in healthy ageing

Remarque, E.J. (author), Nijhuis, E.W.P. (author), Hinloopen, B. (author), Nagelkerken, L. (author), van der Velde, E.A. (author), Ligthart, G.J. (author), Instituut voor Experimentele Gerontologie TNO (author)

To investigate the effects of the altered composition of the helper T cell compartment in ageing on the humoral response to influenza vaccine, we investigated correlations between helper T cell subsets and anti-influenza antibody responses in 23 JUNIEUR healthy young and 41 SENIEUR healthy elderly subjects. Naive helper T cell numbers (CD4...

article 1996

document

HLA-B27 as a relative risk factor in ankylosing enthesopathy in transgenic mice

Weinreich, S. (author), Eulderink, F. (author), Capkova, J. (author), Pla, M. (author), Gaede, K. (author), Heesemann, J. (author), van Alphen, L. (author), Zurcher, C. (author), Hoebe-Hewryk, B. (author), Kievits, F. (author), Ivanyi, P. (author), Instituut voor Experimentele Gerontologie TNO (author)

HLA-B27 is a risk factor for several human diseases through a mechanism that is not yet understood. This article describes a naturally occurring joint disease in laboratory mice, ANKENT. ANKENT begins with mild inflammation and culminates in irreversible stiffening of the ankle and/or tarsal joints in one or both hind paws. The macroscopic and...

article 1995

document

Visualization of uptake and processing of lipoproteins by various liver cell types

Gezondheidsorganisatie TNO Instituut voor experimentele gerontologie TNO Instituut voor verouderings- en vaatziekten onderzoek TNO (author), Esbach, S. (author)

doctoral thesis 1993

document

Genomic instability and aging

Gaubius instituut Instituut voor experimentele gerontologie TNO (author), Slagboom, P.E. (author)

doctoral thesis 1993

document

Inleiding gerontologie en geriatrie

Instituut voor experimentele gerontologie TNO (author), Eulderink, F. (author), Heeren, T.J. (author), Knook, D.L. (author), Ligthart, G.J. (author)

Dit boek bevat wat de basisarts moet weten over veroudering. Het behandelt eerst de belangrijkste aspecten van normale veroudering (Gerontologie), daarna de geneeskunde bij ouderen (Geriatrie) voor zover die anders is dan bij jongeren. Veroudering is het optreden van ogenschijnlijk spontane, irreversibele veranderingen met de tijd. Deze...

book 1993

document

Metabolic and functional aspects of retinoids (vitamin A)

Instituut voor verouderings- en vaatziekten onderzoek TNO Instituut voor experimentele gerontologie TNO (author), van Bennekum, A.M. (author)

doctoral thesis 1993

document

Genetic and functional analysis of apolipoprotein E

Gezondheidsorganisatie TNO Instituut voor verouderings- en vaatziekten onderzoek TNO Instituut voor experimentele gerontologie TNO (author), van den Maagdenberg, A.M.J.M. (author)

doctoral thesis 1993

document

Immunologic abnormalities in canine juvenile polyarteritis syndrome: A naturally occurring animal model of Kawasaki disease

Felsburg, P.J. (author), Instituut voor experimentele gerontologie TNO (author)

article 1992

document

Increased sensitivity of old rats to bacterial endotoxins

Instituut voor experimentele gerontologie TNO Instituut voor verouderings- en vaatziekten onderzoek TNO (author), Brouwer, A. (author)

doctoral thesis 1992

document

The involvement of the intestinal microflora in the expansion of CD4+ T cells with a naive phenotype in the periphery

Instituut voor Experimentele Gerontologie TNO Institute of Ageing and Vascular Research TNO (author), Dobber, R. (author), Hertogh-Huijbregts, A. (author), Rozing, J. (author), Bottomly, K. (author), Nagelkerken, L. (author)

It is well known that immune reactivity declines with age. Recently, we demonstrated that the age-related decrease in IL-2 production by CD4+ T cells was accompanied by an increased production of IL-4 and interferon-gamma (IFN-gamma). This age-related shift in the profile of lymphokine production was related to phenotypic changes within the CD4+...

article 1992

document

Monoclonal gammapathies III: clinical significance and basic mechanisms: proceedings of the third Eurage symposium, Brussels, September 19-20, 1991

Radl, J. (author), van Camp, B. (author), Instituut voor Experimentele Gerontologie TNO (author)

book 1991

document

Expression of growth factors and their receptors on human sarcomas. Immunohistochemical detection of platelet-derived growth factor, epidermal growth factor and their receptors

Roholl, P.J.M. (author), Weima, S.M. (author), Prinsen, I. (author), de Weger, R.A. (author), den Otter, W. (author), van Unnik, J.A.M. (author), Instituut voor Verouderings- en Vaatziekten Onderzoek TNO Instituut voor Experimentele Gerontologie TNO (author)

The expression of both platelet-derived growth factor (PDGF) and epidermal growth factor (EGF), and of their receptors was examined immunohistochemically in a number of normal tissues as well as in benign and malignant mesenchymal tumors. The benign lesions studied were from the skin: palmar fibromatosis (fibroblastic) and from the uterus:...

article 1991

document

The influence of ageing on the pharmacodynamics of sedative and anticonvulsant drugs in rats

Instituut voor verouderings- en vaatziekten onderzoek TNO Instituut voor experimentele gerontologie TNO (author), Stijnen, A.M. (author)

doctoral thesis 1991

document

Retinoid (vitamin A) metabolism in rat liver

Gezondheidsorganisatie TNO Instituut voor verouderings- en vaatziekten onderzoek TNO Instituut voor experimentele gerontologie TNO (author), Hendriks, H.F.J. (author)

doctoral thesis 1991

document

Knowledge, attitude and practice in antiepileptic drug monitoring

Gezondheidsorganisatie TNO Instituut voor verouderings- en vaatziekten onderzoek TNO Instituut voor experimentele gerontologie TNO (author), Meijer, J.W.A. (author)

doctoral thesis 1991

document

Duizeligheid als signaal bij ouderen

Instituut voor experimentele gerontologie TNO (author)

book 1990

document

Interaction of lipoproteins with liver cells

Gezondheidsorganisatie TNO Instituut voor experimentele gerontologie TNO (author), Kleinherenbrink-Stins, M. (author)

doctoral thesis 1990

document

The 5T mouse multiple myeloma model: Absence of c-myc oncogene rearrangement in early transplant generations

Instituut voor Experimentele Gerontologie TNO (author), Radl, J. (author), Punt, Y.A. (author), van den Enden-Vieveen, M.H.M. (author), Bentvelzen, P.A.J. (author), Bakkus, M.H.C. (author), van den Akker T., W. (author), Benner, R. (author)

Consistent chromosomal translocations involving the c-myc cellular oncogene and one of the three immunoglobulin loci are typical for human Burkitt's lymphoma, induced mouse plasmacytoma (MPC) and spontaneously arising rat immunocytoma (RIC). Another plasma cell malignancy, multiple myeloma (MM), arising spontaneously in the ageing C57BL/KaLwRij...

article 1990

document

mRNA levels and methylation patterns of the tyrosine aminotransferase gene in aging inbred rats

Instituut voor Experimentele Gerontologie TNO (author), Slagboom, P.E. (author), Leeuw, W.J.F.de (author), Vijg, J. (author)

We have examined the mRNA levels and methylation patterns of the liver-specific tyrosine aminotransferase (TAT) gene in inbred female rats aged 6, 24 and 36 months. Northern hybridization analysis of total RNA showed a 65% decrease in the steady state transcript level of TAT in the liver of 24- and 36-month old rats as compared to 6-month old...

article 1990

document

Variations in reported serum alkaline phosphatase activities

Instituut voor Experimentele Gerontologie TNO (author), Parker, S.G. (author)

article 1990