document

Dietary selenium, selenium status, fat consumption and body composition: A case-control study on the etiology of pre- and postmenopausal breast cancer

van 't Veer, P. (author), van Faassen, A. (author), Egger, R.J. (author), Ockhuizen, T. (author), Hermus, R.J.J. (author), Sturmans, F. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)

Dìet is considered to be a potentiaì1y modifiabìe exposure which mìght give opportunities to reduce breast cancer incidence (l ). It is, however, not known whìch specìfic factors are the most important causes of breast cancer in the Netherlands. Results of correlation studies suggest that the relatìveìy high Dutch breast cancer incidence and...

article 1985

document

Effects of endotoxin-treatment on inflammatory cell infiltrates in murine Meth A sarcoma

Kuper, C.F. (author), Bloksma, N. (author), Bruyntjes, J.P. (author), Hofhuis, F.M. (author), Wolferink, G. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)

The effect of intravenously injected endotoxin on inflammatory cells within solid Meth A tumours was studied and central hyperaemia, necrosis and early collapse were observed macroscopically at 4, 24 and 48 h, respectively. The effects were studied in semithin sections and cytocentrifuge preparations of the tumours. The inflammatory cell...

article 1985

document

Vitamins and endurance training: Food for running or faddish claims?

van der Beek, E.J. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)

The inter-relationship of food and physical performance, food is considered as a conglomerate of nutrients and man is depicted as a kind of organic pudding. This 'machine' concept of human performance in combination with the mysticism surrounding vitamins, has led to the faddish belief that additional vitamins are necessary to improve physical...

article 1985

document

Selenium en vet in de voeding in relatie tot borstkanker: een patient controle onderzoek bij pre-en postmenopauzale vrouwen

Instituut CIVO-Toxicologie en voeding TNO (author), van 't Veer, P. (author), Egger, R.J. (author), van Faassen, A. (author), Ockhuizen, T. (author), Sturmans, F. (author), Hermus, R.J.J. (author)

Voordracht en bijeenkomst 11e WEON-bijeenkomst, 2 en 3 mei 1985 te Amsterdam.

article 1985

document

Voeding en voedingstoestand van migranten-kinderen van Mediterrane herkomst

Instituut CIVO-Toxicologie en voeding TNO (author), Meulmeester, J.F. (author), Bovens, M. (author), Wedel, M. (author), Luyken, R. (author)

Voordracht en bijeenkomst 11e WEON-bijeenkomst, 2 en 3 mei 1985 te Amsterdam.

article 1985

document

Mutagenicity of urine and faeces after treatment of rats with known genotoxins

Instituut CIVO-Toxicologie en Voeding TNO (author), Willems, M.I. (author), de Raat, W.K. (author)

article 1985

document

Restoration of the hamster tracheal wall following injury by electrocoagulation

Feron, V.J. (author), Immel, H.R. (author), Spit, B.J. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)

The trachea of Syrian golden hamsters was injured by electrocoagulation. The lesions induced as well as the repair process were studied by light and scanning electron microscopy. The changes observed were considered to create the proper conditions for studying the significance of severe focal damage to the respiratory tract for the formation of...

article 1984

document

Modifying effect of vitamin A on benzo[a]pyrene-induced respiratory tract tumours in hamsters

Beems, R.B. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)

Chemicals/CAS: benzo[a]pyrene, 50-32-8; retinol, 68-26-8, 82445-97-4; Benzo(a)pyrene, 50-32-8; Benzopyrenes; Vitamin A, 11103-57-4

article 1984

document

Inhalation toxicity of acetaldehyde in rats. II. Carcinogenicity study: Interim results after 15 months

Woutersen, R.A. (author), Appelman, L.M. (author), Feron, V.J. (author), van der Heijden, C.A. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)

Male and female Wistar rats were exposed to acetaldehyde vapour at concentrations of 0, 750, 1500 and 3000/1000 ppm during 6 h/day, 5 days/week for up to 27 months. The present paper deals with the results obtained during the first 15 months of the study, including interim kills after 13, 26 and 52 weeks. Major compound-related lesions occurred...

article 1984

document

Therelationship of diet, body composition, physical activity and quality of metabolic control to blood lipid levels in type-I-diabetic men

van der Beek, E.J. (author), Wedel, M. (author), van de Zedde, A. (author), Bovens, M. (author), Leep, B.J. (author), Hermus, R.J.J. (author), Schouten, J.A. (author), van der Veen, E.A. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)

Twenty seven male patients, with Type-I diabetes mellitus were studied, all from the Outpatient Clinic of the Department of Internal Medicine, the Free University Hospital, Amsterdam. In comparison with healthy subjects and as regards age, total cholesterol and LDL-cholesterol levels were within normal limits, although HDL-cholesterol and...

article 1984

document

Fluorometric determination of total vitamin C in whole blood by high-performance liquid chromatography with pre-column derivatization

Instituut CIVO-Toxicologie en Voeding TNO (author), Speek, A.J. (author), Schrijver, J. (author), Schreurs, W.H.P. (author)

A reliable and semi-automated high-performance liquid chromatographic (HPLC) method is described for the determination of total vitamin C in whole blood. After deproteinization of whole blood and enzymatic oxidation of l-ascorbic acid to dehydro-l-ascorbic acid, the latter is condensed with o-phenylenediamine to its quinoxaline derivative. This...

article 1984

document

Re-evaluation of the haptoglobin reference values with the radial immunodiffusion technique

Instituut CIVO-Toxicologie en Voeding TNO (author), Schrijver, J. (author), van Rijn, H.J.M. (author), Schreurs, W.H.P. (author)

The reference values of the three main types of serum haptoglobin Hp 1-1, Hp 2-1, and Hp 2-2, as determined by radial immunodiffusion and with phenotype determination on polyacrylamide gel electrophoresis have been re-evaluated for both sexes. For that purpose about 500 serum samples were collected from normal, healthy Dutch volunteers. The...

article 1984

document

Fluorometric determination of total vitamin C and total isovitamin C in foodstuffs and beverages by high-performance liquid chromatography with precolumn derivatization

Instituut CIVO-Toxicologie en Voeding TNO (author), Speek, A.J. (author), Schrijver, J. (author), Schreurs, W.H.P. (author)

A reliable and sensitive high-performance liquid chromatographic (HPLC) method is described for the simultaneous determination of total vitamin C (l-ascorbic acid, AA, plus dehydro-1-ascorbic acid, DHAA) and its C-5 epimer, total isovitamin C (erythorbic acid, EA, plus dehydroerythorbic acid, DHEA), in foodstuffs and beverages. After extraction...

article 1984

document

Electrocoagulation as a method to induce local lesions in the tracheal wall of Syrian hamsters

Instituut CIVO-Toxicologie en Voeding TNO (author), Reuzel, P.G.J. (author), Immel, H.R. (author), Spit, B.J. (author), Feron, V.J. (author)

article 1984

document

Short-term tests in the framework of carcinogen risk assessment to man

Kroes, R. (author), Instituut CIVO-Toxicologie en voeding TNO (author)

Short-term tests designed to detect possible carcinogenicity have been extensively refined during the last years. Presently, many more or less simple and convenient systems are available to detect mutations, chromosome effects, DNA damage, and malignant transformation. Although their relevance to carcinogenicity is often reasonably good,...

article 1983

document

Enkele aspecten van de ontwikkeling van de voedingstoestand van geselecteerde groepen Nederlandse adolescenten en jonge volwassenen 1960-1975

Luyken, R. (author), Luyken-Koning, F.W.M. (author), de Wijn, J.F. (author), Instituut CIVO-Toxicologie en voeding TNO Instituut TNO voor wiskunde, informatieverwerking en statistiek (author)

article 1983

document

Tissue damage and nutritional factors in experimental respiratory tract (co-)carcinogenesis

Reuzel, P.G.J. (author), Feron, V.J. (author), Spit, B.J. (author), Beems, R.B. (author), Kroes, R. (author), Instituut CIVO-Toxicologie en voeding TNO (author)

Cofactors involved in respiratory tract carcinogenesis were studied in Syrian golden hamster or in rats using benzo(a)pyrene as the carcinogenic agent. These factors included severe tissue tissue damage induced by electro-coagulation, glass fibers administered by intratracheal instillation, acetaldehyde as irritant vapor, food restriction, and...

article 1983

document

Overvoeding, overgewicht, vroegtijdige sterfte

Hermus, R.J.J. (author), Instituut CIVO-Toxicologie en voeding TNO (author)

article 1983

document

Diet, faecal pH and colorectal cancer

Instituut CIVO-Toxicologie en voeding TNO (author), van Dokkum, W. (author), de Boer, B.C.J. (author), van Faassen, A. (author), Pikaar, N.A. (author), Hermus, R.J.J. (author)

We suggest that a lower faecal pH may be correlated with a lower mortality of large-bowel cancer and that faecal pH should always be considered in epidemiological studies on the role of diet in colon carcinogenesis.

article 1983

document

Physiological effects of fibre-rich types of bread. 2. Dietary fibre from bread: digestibility by the intestinal microflora and water-holding capacity in the colon of human subjects

Instituut CIVO-Toxicologie en voeding TNO Instituut voor Wiskunde, Informatieverwerking en Statistiek TNO (author), van Dokkum, W. (author), Pikaar, N.A. (author), Thissen, J.T.N.M. (author)

article 1983