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Muijser, H. (author), Geuskens, R.B.M. (author), Hooisma, J. (author), Emmen, H.H. (author), Kulig, B.M. (author), TNO Voeding (author)Carpet layers and age-matched controls were investigated both at the beginning of a working day and at the end with four subtests of a neuropsychological test battery (NES2). Exposure to toluene, cyclohexane, ethyl acetate, and heptane was measured with personal air sampling methods. One group of carpet layers used water-based adhesives (WBA) on...article 1996
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van der Laan, G. (author), van Dun, R.E.C.S. (author), Roos, Y. (author), Wekkings, T. (author), Hooisma, J. (author), Kulig, B. (author), Emmen, H.H. (author), Monster, A.C. (author), de Wolff, F.A. (author)In dit rapport wordt de ontwikkeling van een protocol voor de diagnostiek van het organisch psychosyndroom door werken met neurotoxische stoffen besproken. Langdurige blootstelling aan hoge concentraties oplosmiddelen kan chronische effecten op het centraal zenuwstelsel veroorzaken. Beoordeling van patiënten met mogelijke chronische...book 1995
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- Salthouse, A.T. (author), Letz, R. (author), Hooisma, J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author) article 1994
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- Ruijten, M.W.M.M. (author), Hooisma, J. (author), Brons, J. (author), Habets, T. (author), Emmen, H.H. (author), Muijser, H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author) article 1994
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- Jaspers, R.M.A. (author), Hooisma, J. (author), Kulig, B.M. (author), Medisch Biologisch Laboratorium TNO Centraal Instituut voor Voedingsonderzoek TNO (author) bookPart 1993
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Medisch Biologisch Laboratorium TNO (author), Hooisma, J. (author), Hänninen, H. (author), de Weerd, A. (author), Emmen, H.H. (author), Poortvliet, D. (author), Kulig, B. (author)In dit rapport worden de resultaten beschreven van een dwarsdoorsnede onderzoek naar de effecten van expositie aan organische oplosmiddelen bij jonge en oudere schilders. Het doel van het onderzoek was tweeledig nl. (a) het verzamelen van informatie betreffende het voorkomen van subjectieve klachten als gevolg van blootstelling aan organische...book 1992
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Medisch Biologisch Laboratorium TNO (author), Emmen, H.H. (author), Hooisma, J. (author), Kullig, B.M. (author), Brouwer, E.J. (author)The purpose of the present study was to evaluate the possible effects of occupational exposure to pesticides on central nervous system (CNS) function. A variety of neurobehavioral functions were assessed in a group of 129 workers in the bulb growing industry with at least ten years occupational exposure to pesticides and a group of 64 controls...book 1992
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Medisch Biologisch Laboratorium TNO (author), Brouwer, E.J. (author), Brouwer, D.H. (author), Bruynzeel, D.P. (author), Emmen, H.H. (author), van Hemmen, J.J. (author), Hooisma, J. (author), Jonkman, E.J. (author), Ruijten, M.W.M.M. (author), Salle, H.J.A. (author), Sjardin, W. (author), Verberk, M.M. (author), Vermeulen, N.P.E. (author), de Weerd, A.W. (author), van Welie, R.T.H. (author), Zielhuis, R.L. (author), de Wolff, F.A. (author)In the Dutch flower bulb culture a large number of pesticides is used for different applications : weed control, crop protection, disinfection of barns (stock protection) and soil, and bulb disinfection. A study was therefore carried out in order to investigate : (1) the type and extent of exposure to pesticides in the flower bulb culture, and ...book 1992
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- Medisch Biologisch Laboratorium TNO (author), Hooisma, J. (author), Emmen, H.H. (author), Kulig, B.M. (author) bookPart 1992
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Hooisma, J. (author), Twisk, D.A.M. (author), Platalla, S. (author), Muijser, H. (author), Kulig, B.M. (author), Medisch Biologisch Laboratorium TNO (author)The performance characteristics of 4 computerized psychological tests were studied using alcohol as a model compound. Subjects received alcohol (0.5 ml/kg) or placebo in a cross-over design and performance was assessed using the Simple Reaction Time test, the Switching Attention test, the Hand/Eye Coordination test and the Color-Word Vigilance...article 1988
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Medisch Biologisch Laboratorium TNO (author), Muijser, H. (author), Hoogendijk, E.M.G. (author), Hooisma, J. (author), Twisk, D.A.M. (author)In a group of workers exposed to high levels of lead during five months nerve conduction velocity parameters were evaluated at the termination of exposure, and also three and fifteen months later. At the termination of exposure the mean blood lead level was 4.0 ??mol/l, and motor conduction velocities in the median and the ulnar nerves were...article 1987
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Hooisma, J. (author), Medisch Biologisch Laboratorium TNO (author)Application of tissue culture in neurotoxicology may serve two purposes. First, they may be used to unravel the mechanism of action of neurotoxic compounds and secondly, they may be used for the screening of neurotoxic agents. Studies belonging to the first group can be subdivided into those aiming at the replication of neurotoxic processes in...article 1982
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Hooisma, J. (author), Dam, E.W. (author), Medisch Biologisch Laboratorium TNO (author)Chemicals/CAS: 2 hexanone, 591-78-6; acetonylacetone, 110-13-4; hexane, 110-54-3article 1981
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Magchielse, T. (author), Hooisma, J. (author), Muijser, H. (author), Medisch Biologisch Laboratorium TNO (author)The measurement of passive electrical membrane properties in cultured muscle cells is complicated by the fact that the electrotonic length in these cells often exceeds their actual length, leading to serious deviations from the simple infinite cable behaviour. By using very short current pulses for these measurements and integrating the...article 1981
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Hooisma, J. (author), de Krijger, J. (author), de Groot, D.M.G. (author), Medisch Biologisch Laboratorium TNO (author)Previously tropic effects of extracts from whole chick embryos and from innervated muscles on cultured muscle cells were described. The present study demonstrated similar effects of extracts from 10-days denervated chick muscles. Extracts from innervated as well as from denervated muscles exsanguinated in vivo with saline prior to dissection...article 1981
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Medisch Biologisch Laboratorium TNO (author), Hooisma, J. (author), Groot, D.M.G.de (author), Magchielse, T. (author), Muijser, H. (author)Chick spinal ganglia, chick muscle cells combined with mouse spinal cord explants, C1300 neuroblastoma cells, Chinese hamster ovary cells and newborn rat cerebral cells were exposed to various concentrations of acrylamide in culture. Four morphological and 1 electrophysiological parameter were applied in order to score toxic effects. It appeared...article 1980
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Slaaf, D.W. (author), Hooisma, J. (author), Meeter, E. (author), Stevens, W.F. (author), Medisch Biologisch Laboratorium TNO (author)Electrophysiological and pharmacological properties of neuromuscular junctions formed in tissue culture between chick ciliary ganglia and chick skeletal muscle cells have been studied. Functional neuromuscular junctions are formed already within 24h. No functional acetylcholine (ACh) esterase is present at these endplates. The neurites conduct...article 1979
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Hooisma, J. (author), Slaaf, D.W. (author), Meeter, E. (author), Stevens, W.F. (author), Medisch Biologisch Laboratorium TNO (author)The influence of various neural explants on the morphology and the survival of chick muscle fibers was studied. A method was developed to evaluate the condition of the muscle fibers using the following four morphological parameters: cross striation, thickness, number of fibers and absence of vacuoles. Chick as well as mouse spinal cord explants...article 1978
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Stevens, W.F. (author), Slaaf, D.W. (author), Hooisma, J. (author), Magchielse, T. (author), Meeter, E. (author), Medisch Biologisch Laboratorium TNO (author)A less complicated source of neurons suitable for this type of studies is the parasympathetic ciliary ganglion. In the pigeon and in the chick this ganglion is known to contain only two classes of neurons, both of which are cholinoceptive and cholinergic and that innervate the muscle fibres of the choroid plexus of the eye, the sphincter iridis...article 1978
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- Medisch Biologisch Laboratorium TNO (author), Hooisma, J. (author) doctoral thesis 1977