Modulation of induced aberrant crypt foci (ACF) and colorectal cancer in azoxymethane-treated rats by novelose 330, cellulose and fat

Effect of dietary galacto-oligosaccharides on azoxymethane-induced aberrant crypt foci and colorectal cancer in Fischer 344 rats

The aim of the present study was to investigate the effects of galacto-oligosaccharides (GOS, Elix'or) on the development of aberrant crypt foci (ACF) and colorectal tumours in rats treated with azoxymethane (AOM). Two groups of 102 male Fischer 344 rats were injected twice with AOM to induce colorectal tumours, and fed diets containing either a...

A comparison of the effects of dietary cellulose and fermentable galacto-oligosaccharide, in a rat model of colorectal carcinogenesis: Fermentable fibre confers greater protection than non-fermentable fibre in both high and low fat background

The objective of this experiment was to compare the effects of diets with either a non-fermentable fibre source (cellulose) or a fermentable fibre source [galacto-oligosaccharide (GOS)], combined with different levels of dietary fat, on the development of colorectal cancer. Male Wistar rats were fed AIN76-based diets with either a low or high...

Absence of an inhibitory effect of a vegetables-fruit mixture on the initiation and promotion phases of azoxymethane-induced colorectal carcinogenesis in rats fed low- or high-fat diets

The potential inhibitory effects of a vegetables-fruit mixture on the initiation and promotion phases of azoxymethane-induced colorectal carcinogenesis were examined in rats fed low- or high-fat diets. Rats were fed low-fat diets (20 energy percent, Diets A and B) or high-fat diets (40 energy percent, Diets C and D), supplemented with a...

Effects of a dietary load of acid or base on changes induced by lactose in rats

Multigeneration reproduction study of lactitol in rats

Lactitol is a disaccharide sugar alcohol (polyol) which holds promise as a reduced calorie, noncariogenic sugar substitute. In a multigeneration reproduction study, lactitol was fed to Wistar-derived Cpb:WU rats of both sexes throughout three successive generations at dietary concentrations of 0, 2, 5, and 10%. A comparison group receiving a...

Subchronic and chronic toxicity/carcinogenicity feeding studies with lactitol in rats

The toxicity and possible carcinogenicity of lactitol, a lactose-derived reduced calorie sugar substitute, were examined in Wistar Cpb:WU rats. In a first 13-week study, groups of 10 weanling rats of each sex were fed diets containing 0, 5, 10, or 20% lactitol, or 25% lactose. In a second 13-week study, groups of 20 rats of each sex received...

Chronic toxicity and carcinogenicity study of lactitol in mice

Lactitol is a sweet-tasting disaccharide sugar alcohol with potential applications as a reduced calorie sugar substitute. In a chronic toxicity/carcinogenicity study, groups of 50 male and 50 female Cpb:Swiss random (SPF) mice received diets containing 0, 2, 5, and 10% lactitol for 104 weeks. The test compound was added to the diet at the...