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Bogdanovic, J. (author), Koets, M. (author), Sander, I. (author), Wouters, I. (author), Meijster, T. (author), Heederik, D. (author), van Amerongen, A. (author), Doekes, G. (author), TNO Kwaliteit van Leven (author)Background: Occupational allergen exposure assessment usually requires airborne dust sampling at the worksite followed by dust extraction and enzyme immunoassay (EIA) analysis at the laboratory. Use of semiquantitative lateral flow immunoassays (LFIAs) may allow a more rapid detection procedure with direct on-site demonstration of a bioallergen...article 2006
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Pronk, A. (author), Yu, F. (author), Vlaanderen, J. (author), Tielemans, E. (author), Preller, L. (author), Bobeldijk, I. (author), Deddens, J.A. (author), Latza, U. (author), Baur, X. (author), Heederik, D. (author), TNO Kwaliteit van Leven (author)Objectives: To study inhalation and dermal exposure to hexamethylene diisocyanate (HDI) and its oligomers as well as personal protection equipment (PPE) use during task performance in conjunction with urinary hexamethylene diamine (HDA) in car body repair shop workers and industrial spray painters. Methods: Personal task based inhalation samples...article 2006
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Portengen, L. (author), Preller, L. (author), Tielen, M. (author), Doekes, G. (author), Heederik, D. (author), TNO Kwaliteit van Leven (author)Background: Recent studies have reported a low prevalence of atopic sensitization and respiratory allergy in children growing up on farms. Objectives: We sought to evaluate the dose-response relationship between endotoxin and atopic sensitization in adult farmers and to assess the effect on respiratory health outcomes. Methods: Data on endotoxin...article 2005
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Heederik, D. (author), Pronk, A. (author), Doekes, G. (author), Bobbeldijk, I. (author), Preller, L. (author), TNO Kwaliteit van Leven (author)Isocyanate allergy and asthma is an important respiratory disease in most industrialized countries. Little information about its importance is available for the Netherlands. A baseline survey, part of a larger longitudinal epidemiological survey, shows that exposure to mainly HDI monomers and oligomers is present. The respiratory symptoms...article 2005
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Risk assessment of silicosis and lung cancer among construction workers exposed to respirable quartzTNO Kwaliteit van Leven TNO Voeding (author), Tjoe Nij, E. (author), Heederik, D. (author)Objectives: The aim of this study was to assess the magnitude of the silicosis and cancer risk among construction workers. Methods: In 1998, 1335 of 4173 invited construction workers with expected high cumulative exposure to quartz were studied for early signs of silicosis. In 2002 the study was repeated for 96 persons. Exposure measurements...article 2005
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TNO Kwaliteit van Leven TNO Voeding (author), Peretz, C. (author), de Pater, N. (author), de Monchy, J. (author), Oostenbrink, J. (author), Heederik, D. (author)In this article, dust and wheat-allergen exposure were assessed among bakers, flour millers, and bakery-ingredient producers, and the risk for sensitization was studied. About 520 inhalable dust and wheat-allergen measurements were made among 270 Dutch workers. The effect of exposure to both inhalable dust and wheat allergens on sensitization...article 2005
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- Tielemans, E. (author), Heederik, D. (author), Kromhout, H. (author), van Hemmen, J. (author), Meijster, T. (author), Fransman, W. (author), Spaan, S. (author), TNO Voeding (author) article 2004
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TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author), Tielemans, E. (author), Heederik, D. (author), Kromhout, H. (author), van Hemmen, J. (author), Meijster, T. (author), Fransman, W. (author), Spaan, S. (author)Dit artikel beschrijft een benadering om op branche niveau trends in blootstelling aan chemische en biologische agentia te onderzoeken. Hiervoor is de internationale literatuur over blootstellingstrends geïntentariseerd en beschreven. Hierbij is gebleken dat blootstellingsveranderingen in verschillende industrieën zijn onderzocht. Deze zijn...article 2004
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Smit, L.A.M. (author), van Wendel- de Joode, B.N. (author), Heederik, D. (author), Peiris-John, R.J. (author), van der Hoek, W. (author)Background: In many agricultural districts in Sri Lanka, pesticide poisoning is a leading cause of death. This study aims to evaluate the impact of pesticide use on Sri Lankan farmers' health. Methods: A total of 260 subjects were surveyed in both a low and a high exposure period. Acetylcholinesterase activity was measured and data on symptoms...article 2003
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de Pater, N. (author), Doekes, G. (author), Miedema, E. (author), Goede, H. (author), van Hemmen, J. (author), Heederik, D. (author)Beroepsmatige blootstelling aan meelstof kan leiden tot klachten aan de luchtwegen zoals astma en rhinitis. Deze klachten worden toegeschreven aan de in het stof aanwezige tarwe-allergenen en schimmel alpha-amylase. Het doel van het onderzoek is op basis van de resultaten een taakstelling te formuleren voor een reductie van de blootstelling aan...book 2003
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- Tielemans, E. (author), Burdorf, A. (author), te Velde, E. (author), Weber, R. (author), van Kooij, R. (author), Heederik, D. (author), TNO Voeding (author) article 2002
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- van Wendel de Joode, B. (author), Tjoe Nij, E. (author), Doekes, G. (author), Heederik, D. (author), TNO Voeding (author) conference paper 2002
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Tielemans, E. (author), Louwerse, E. (author), de Cock, J. (author), Brouwer, D. (author), Zielhuis, G. (author), Heederik, D. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)As part of a European Concerted Action on Male Reproduction Capability an exposure assessment survey was conducted among seasonal workers in the fruit growing sector in the Netherlands. Dermal exposure to the fungicides captan and tolylfluanid was measured using cotton gloves (12 persons) and skin pads on several body parts (12 persons). In...article 1999
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- Tielemans, E. (author), Louwerse, E. (author), de Cock, J. (author), Brouwer, D. (author), Zielhuis, G. (author), Heederik, D. (author) article 1999
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TNO Voeding (author), Peelen, S. (author), Roeleveld, N. (author), Heederik, D. (author), Kromhout, H. (author), de Kort, W. (author)Naar aanleiding van Kamervragen over mogelijke effecten op de voortplanting en/of het nageslacht als gevolg van beroepsmatige blootstelling aan chemische stoffen werd in het najaar van 1995 door het Ministerie van Sociale Zaken en Werkgelegenheid een onderzoek geïnitieerd naar reproductie-toxische effecten bij ziekenhuispersoneel met de volgende...book 1999
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- de Cock, J. (author), Heederik, D. (author), Kromhout, H. (author), Boleij, J.S.M. (author), Hoek, F. (author), Wegh, H. (author), Tjoe Ny, E. (author), Centraal Instituut voor Voedingsonderzoek TNO (author) article 1998
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Bongers, P.M. (author), Heederik, D. (author)The Dutch prospective study on the determinants of musculoskeletal disorders (n = 1763 ) is the first study in this field that quantified physical load at the workplace on a large scale. Baseline assessment of physical load was based on videorecordings and force measurements at the workplace and observations of posture, movement and force...conference paper 1998
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- de Cock, J. (author), Heederik, D. (author), Kromhout, H. (author), Boleij, J.S.M. (author), TNO Voeding (author) article 1996
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- de Cock, J. (author), Kromhout, H. (author), Heederik, D. (author), Burema, J. (author), TNO Voeding (author) article 1996