- document
-
Meijster, T. (author), Warren, N. (author), Heederik, D. (author), Tielemans, E. (author), TNO Kwaliteit van Leven (author)Recently a dynamic population model was developed that simulates a population of bakery workers longitudinally through time and tracks the development of work-related sensitisation and respiratory symptoms in each worker. Input for this model comes from cross-sectional and longitudinal epidemiological studies which allowed estimation of exposure...article 2009
- document
-
Baatjies, R. (author), Lopata, A.L. (author), Sander, I. (author), Raulf-Heimsoth, M. (author), Batemane, E.D. (author), Meijster, T. (author), Heederik, D. (author), Robins, T.G. (author), Jeebhay, M.F. (author), TNO Kwaliteit van Leven (author)While baker's asthma has been well described, various asthma phenotypes in bakery workers have yet to be characterised. Our study aims to describe the asthma phenotypes in supermarket bakery workers in relation to host risk factors and self-reported exposure to flour dust. A cross-sectional study of 517 supermarket bakery workers in 31 bakeries...article 2009
- document
-
Jacobs, J.H. (author), Meijster, T. (author), Meijer, E. (author), Suarthana, E. (author), Heederik, D. (author), TNO Kwaliteit van Leven (author)Background: Occupational airway diseases are common among bakers. The present study describes the association between exposure to wheat allergen levels and sensitization to wheat allergens, work-related upper and lower respiratory symptoms and asthma in bakery workers. Methods: As part of a Health Surveillance System for early detection of ...article 2008
- document
-
Meijster, T. (author), Tielemans, E. (author), Schinkel, J. (author), Heederik, D. (author), TNO Kwaliteit van Leven (author)Objectives: To effectively decrease occupational exposure to flour dust and related allergens, detailed information on exposure determinants and effectiveness of control measures is essential. In this paper, we use personal real-time exposure measurements to get more insight into the relationship between specific work characteristics, including...article 2008
- document
-
Stuurman, B. (author), Meijster, T. (author), Heederik, D. (author), Doekes, G. (author), TNO Kwaliteit van Leven (author)Objectives: To obtain an overview of inhalable β(1→3)glucans levels in Dutch industrial bakeries and explore possible associations with reported respiratory health effects in bakery workers. Methods: β(1→3)glucan levels were analysed in 186 personal inhalable dust measurements obtained from a random population of bakery workers. Association...article 2008
- document
-
Spaan, S. (author), Schinkel, J. (author), Wouters, I.M. (author), Preller, L. (author), Tielemans, E. (author), Nij, E.T. (author), Heederik, D. (author), TNO Kwaliteit van Leven (author)Objectives: Workers in many industries are exposed to endotoxins, which may cause adverse health effects. In exposure assessment, information about exposure variability is essential. However, variability in exposure has rarely been investigated for biological agents and more specifically for endotoxin. Therefore, variance components and...article 2008
- document
-
Bobeldijk, I. (author), Karlsson, D. (author), Pronk, A. (author), Gonsalves, J. (author), Hekman, M. (author), van de Lagemaat, D. (author), Preller, L. (author), Heederik, D. (author), Skarping, G. (author), TNO Kwaliteit van Leven (author)An adapted method for the quantitative determination of isocyanates in air was implemented and validated in-house. The method was based on air sampling using an impinger flask containing di-n-butylamine (DBA) in toluene and a glass fibre filter in series. The DBA derivatives were determined using liquid chromatography and tandem mass...article 2008
- document
- TNO Kwaliteit van Leven (author), Spaan, S. (author), Schinkel, J. (author), Wouters, I.M. (author), Tjoe Nij, E. (author), Preller, L. (author), Heederik, D. (author), Tielemans, E. (author) report 2008
- document
-
TNO Kwaliteit van Leven (author), Spaan, S. (author), Doekes, G. (author), Heederik, D. (author), Thorne, P.S. (author), Wouters, I.M. (author)The measurement of airborne endotoxins is thus far not standardized. Earlier studies reported higher endotoxin yields when Tween 20 was added to the media used for filter extraction and in the Limulus amebocyte lysate (LAL) assay. This study compared four common media and assessed the effects of Tween during extraction and analysis separately....article 2008
- document
-
Fransman, W. (author), Roeleveld, N. (author), Peelen, S. (author), de Kort, W. (author), Kromhout, H. (author), Heederik, D. (author), TNO Kwaliteit van Leven (author)BACKGROUND: Nurses and other hospital workers are exposed to antineoplastic drugs during daily activities. Previous studies suggest that antineoplastic drugs at occupational exposure levels may be toxic to reproduction, but these studies are not consistent or conclusive. METHODS: Self-administered questionnaires were completed by 4393 exposed...article 2007
- document
-
van Wendel de Joode, B. (author), Vermeulen, R. (author), Heederik, D. (author), van Ginkel, K. (author), Kromhout, H. (author), TNO Kwaliteit van Leven (author)We performed an exploratory study to evaluate 2 self-administered questionnaires assessing hand dermatitis and investigate a possible exposure-response relationship between dermal exposure to semi-synthetic metalworking fluids (SMWF) and dermatitis. In a cross-sectional survey on dermatitis, a symptom-based questionnaire and a picture-based skin...article 2007
- document
-
Spaan, S. (author), Schinkel, J.M. (author), Wouters, I.M. (author), Preller, E.A. (author), Tjoe Nij, E.I.M. (author), Heederik, D. (author), Tielemans, E.L.J.P. (author), Preller, L. (author), TNO Kwaliteit van Leven (author)Endotoxin is a well-known toxin which has been associated with several health effects. Many factors influence airborne endotoxin exposure and can cause high variability in exposure between and within workers. Additionally, since the source of endotoxin exposure - gram-negative bacteria - grow and amplify, exposure variability is thought to be...article 2007
- document
- Fransman, W. (author), Roeleveld, N. (author), Peelen, S. (author), de Kort, W. (author), Kromhout, H. (author), Heederik, D. (author), TNO Kwaliteit van Leven (author) article 2007
- document
-
Pronk, A. (author), Preller, L. (author), Raulf-Heimsoth, M. (author), Jonkers, I.C.L. (author), Lammers, J.-W. (author), Wouters, I.M. (author), Doekes, G. (author), Wisnewski, A.V. (author), Heederik, D. (author), TNO Kwaliteit van Leven (author)Rationale: Associations between oligomeric isocyanate exposure, sensitization, and respiratory disease have received little attention, despite the extensive use of isocyanate oligomers. Objectives: To investigate exposure-response relationships of respiratory symptoms and sensitization in a large population occupationally exposed to isocyanate...article 2007
- document
-
Heederik, D. (author), Meijster, T. (author), Spaan, S. (author), Schinkel, J. (author), Tielemans, E. (author), van Niftrik, M. (author)In het kader van het Arboconvenant grondstofallergie is onderzoek gedaan naar de stof- en allergeenblootstelling (tarweallergeen en schimmel a-amylase) in industriële bakkerijen, de maalindustrie en bakkerijgrondstoffenindustrie. De resultaten zijn vergeleken met metingen uit 2000-2001. Er wordt geconcludeerd dat de doelstellingen voor wat...book 2007
- document
- TNO Kwaliteit van Leven (author), Schinkel, J.M. (author), Tjoe Nij, E.I.M. (author), Spaan, S. (author), Tielemans, E.L.J.P. (author), Preller, E.A. (author), wouters, I.M. (author), Heederik, D. (author) report 2007
- document
-
Meijster, T. (author), Fransman, W. (author), van Hemmen, J. (author), Kromhout, H. (author), Heederik, D. (author), Tielemans, E. (author), TNO Kwaliteit van Leven (author)Objective: The main goal was to investigate the potential of a probabilistic approach for exposure assessment and use this information to evaluate the impact of a complex of policy actions/interventions on dermal exposure to antineoplastic agents among oncology nurses. The central theme of this study was to make optimal use of existing data,...article 2006
- document
-
Goldbohm, R.A. (author), Tielemans, E.L.J.P. (author), Heederik, D. (author), Rubingh, C.M. (author), Dekkers, S. (author), Willems, M.I. (author), Dinant Kroese, E. (author), TNO Kwaliteit van Leven (author)It is generally recognized that human, epidemiological data, if available, are preferred as the starting point for quantitative risk analysis above the use of data from animal studies. Although methods to obtain proper risk estimates from epidemiological data are available, several impediments prevent their widespread application. These...article 2006
- document
-
Pronk, A. (author), Tielemans, E. (author), Skarping, G. (author), Bobeldijk, I. (author), van Hemmen, J. (author), Heederik, D. (author), Preller, L. (author), TNO Kwaliteit van Leven (author)As part of a large-scale epidemiological study, occupational isocyanate exposure was assessed in spray-painting environments. The aim was to assess which compounds contribute to isocyanate exposure in car body repair shops and industrial painting companies, and to identify tasks with high risk of isocyanate exposure. Mainly personal task-based...article 2006
- document
-
Meijster, T. (author), Tielemans, E. (author), de Pater, N. (author), Heederik, D. (author), TNO Kwaliteit van Leven (author)Introduction: Recent studies have shown that even low exposure levels to flour dust and related allergens can cause severe respiratory symptoms. In The Netherlands the Dutch government and responsible branch organizations [from bakeries (traditional & industrial), flour mills and bakery ingredient producers] signed a covenant to reduce exposure...article 2006