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Krul, C.A.M. (author), Luiten-Schuite, A. (author), Baan, R. (author), Verhagen, H. (author), Mohn, G. (author), Feron, V. (author), Havenaar, R. (author)The TNO gastro-Intestinal tract Model (TIM) is a dynamic computer-controlled in vitro system that mimics the human physiological conditions in the stomach and small intestine. In the current TIM physiological parameters such as pH, temperature, peristaltic movements, secretion of digestion enzymes, bile and pancreatic juices, and absorption of...article 2000
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- Zeijdner, E.E. (author), Havenaar, R. (author) article 2000
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- Smeets-Peeters, M.J.E. (author), Minekus, M. (author), Havenaar, R. (author), Schaafsma, G. (author), Verstegen, M.W.A. (author) article 1999
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- Havenaar, R. (author) article 1999
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- Minekus, M. (author), Smeets-Peeters, M. (author), Bernalier, A. (author), Marol-Bonnin, S. (author), Havenaar, R. (author), Marteau, P. (author), Alric, M. (author), Fonty, G. (author), Huis in 't Veld, J.H.J. (author) article 1999
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Minekus, M. (author), Smeets-Peeters, M. (author), Havenaar, R. (author), Bernalier, A. (author), Fonty, G. (author), Marol-Bonnin, S. (author), Alric, M. (author), Marteau, P. (author), in 't Huis Veld, J.H.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)This paper introduces a new type of system to simulate conditions in the large intestine. This system combines removal of metabolites and water with peristaltic mixing to obtain and handle physiological concentrations of microorganisms, dry matter and microbial metabolites. The system has been designed to be complementary to the dynamic multi...article 1999
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Havenaar, R. (author), Bonnin-Marol, S. (author), van Dokkum, W. (author), Petitet, S. (author), Schaafsma, G. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)It is well documented that the indigenous microflora, particularly in the colon, plays an important role as a natural resistance factor against pathogenic microorganisms. The number of beneficial bacteria can be increased by specific non-digestible carbohydrates known as prebiotics. One category of prebiotic is inulin, a non-starch...article 1999
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Smeets-Peeters, M.J.E. (author), Minekus, M. (author), Havenaar, R. (author), Schaafsma, G. (author), Verstegen, M.W.A. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)In order to manufacture complete and balanced dog diets, it is important to know the nutrient requirements of dogs and the availability of these nutrients from food. As pet food manufacturers are restricted in their options for (invasive) animal studies, due to ethical constraints, it is important to have alternative methods for researching the...article 1999
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- van der Vossen, J. (author), Havenaar, R. (author) article 1999
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- Venema, K. (author), Zeijder, E.E. (author), Minekus, M. (author), Havenaar, R. (author) conference paper 1999
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- Smeets-Peeters, M. (author), Havenaar, R. (author) article 1999
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- Havenaar, R. (author), Bonnin-Marol, S. (author), van Dokkum, W. (author), Petitet, S. (author), Schaafsma, G. (author) article 1999
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- van der Klis, J.D. (author), Bakker, G.C.M. (author), Havenaar, R. (author), Centraal Instituut voor Voedingsonderzoek TNO (author) bookPart 1999
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- van der Vossen, J.M.B.M. (author), Havekes, W.A.L.M. (author), Koster, D.S. (author), ten Brink, B. (author), Minekus, M. (author), Havenaar, R. (author), Huis in 't Veld, J.H.J. (author), Overeem, J. (author), Hendriks, N. (author), Hofstra, H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author) article 1998
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Spanhaak, S. (author), Havenaar, R. (author), Schaafsma, G. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Objective: To determine the effect of consumption of milk fermented by Lactobacillus casei strain Shirota (L. casei Shirota) on the composition and metabolic activities of the intestinal microflora, and immune parameters in humans. Subjects: Twenty healthy male subjects aged 40-65 years were selected. Design: A placebo-controlled trial was...article 1998
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Smeets-Peeters, M. (author), Watson, T. (author), Minekus, M. (author), Havenaar, R. (author)Food and nutrition studies in animals and human beings often meet with technical difficulties and sometimes with ethical questions. An alternative to research in living animals is the dynamic multicompartmental in vitro model for the gastrointestinal tract described by Minekus et al. (1995) and Havenaar & Minekus (1996). The dynamic conditions...article 1998
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- Havenaar, R. (author), Spanhaak, S. (author), Schaafsma, G. (author), Centraal Instituut voor Voedingsonderzoek TNO (author) bookPart 1998
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- Huis in't Veld, J.H.J. (author), Havenaar, R. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author) article 1997
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- Havenaar, R. (author), TNO Voeding (author) bookPart 1996
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- Havenaar, R. (author), Minekus, M. (author), TNO voeding (author) article 1996