document

The efficiacy of mycotoxin binders proven with a dynamic in vitro model of the gastrointestinal tract

Avantiaggiato, G. (author), Havenaar, R. (author), Visconti, A. (author), TNO Voeding (author)

conference paper 2003

document

The use of a dynamic in vitro model of the gastrointestinal tract in studying mycotoxin adsorbents

Zeijdner, E. (author), Havenaar, R. (author), TNO Voeding (author)

conference paper 2003

document

Effect of prebiotics on avtivity of microbiota and production of metabolites in a dynamic model of the large intestine

Havenaar, R. (author), Venema, K. (author), van Nuenen, M. (author), TNO Voeding (author)

conference paper 2003

document

Folic acid and 5-methyltetrahydrofolate in fortified milk are bioaccessible as determined in a dynamic in vitro gastrointestinal model

Verwei, M. (author), Arkbåge, K. (author), Havenaar, R. (author), van den Berg, H. (author), Witthöft, C. (author), Schaafsma, G. (author), TNO Voeding (author)

Dairy products are a potential matrix for folate fortification to enhance folate consumption in the Western world. Milk folate-binding proteins (FBP) are especially interesting because they seem to be involved in folate bioavailability. In this study, folate bioaccessibility was investigated using a dynamic computer-controlled gastrointestinal...

article 2003

document

The TNO gastro-intestinal model, a unique tool in evaluating gut performance of functional foods and food ingredients

Havenaar, R. (author), Venema, K. (author), Posno, M. (author), TNO Voeding (author)

conference paper 2003

document

Bioaccessibility of Folic Acid and (6S)-5-Methyltetrahydrofolate Decreases after the Addition of Folate-Binding Protein to Yogurt as Studied in a Dynamic in Vitro Gastrointestinal Model

Arkbåge, K. (author), Verwei, M. (author), Havenaar, R. (author), Witthöft, C. (author), TNO Voeding (author)

Milk products are only moderate sources of folate. Nevertheless, they are of interest due to their content of folate-binding proteins (FBP), which in some studies have been reported to increase folate bioavailability. The effect of FBP on folate bioavailability has been widely discussed. The aim of this study was to investigate the...

article 2003

document

Assessing the zearalenone-binding activity of adsorbent materials during passage through a dynamic in vitro gastrointestinal model

Avantaggiato, G. (author), Havenaar, R. (author), Visconti, A. (author), TNO Voeding (author)

A novel approach is presented herein to study the intestinal absorption of mycotoxins by using a laboratory model that mimics the metabolic processes of the gastrointestinal (GI) tract of healthy pigs. This model was used to evaluate the small-intestinal absorption of zearalenone from contaminated wheat (4.1 mg/kg) and the effectiveness of...

article 2003

document

Folate bioaccessibility from various food products studied in a dynamic in vitro gastrointestinal model

Havenaar, R. (author), Verwei, M. (author), Olivares, A.B. (author), Arkbage, K. (author), Ros, G. (author), Witthoft, C. (author), Walker, C. (author), Carnovale, E. (author), Kariuloto, S. (author), Finglas, P. (author), TNO Voeding (author)

conference paper 2003

document

Evaluation of potential mutagenic and antimutagenic properties of food in dynamic in vitro gastrointestinal models

Krul, C.A.M. (author), Schothorst, R. (author), Venema, K. (author), Humblot, C. (author), Havenaar, R. (author)

conference paper 2003

document

TIM: An advanced model for testing dissolution from drug delivery systems simulating dynamics conditions in the GI tract

Zeijdner, E.E. (author), Havenaar, R. (author), Venema, K. (author), Minekus, M. (author), TNO Voeding (author)

conference paper 2002

document

Metabolism of sinigrin (2-propenyl glucosinolate) by the human colonic microflora in a dynamic in vitro large-intestinal model

Krul, C.A.M. (author), Humblot, C. (author), Philippe, C. (author), Vermeulen, M. (author), van Nuenen, M. (author), Havenaar, R. (author), Rabot, S. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

Cruciferous vegetables, such as Brassica, which contain substantial quantities of glucosinolates, have been suggested to possess anticarcinogenic activity. Cutting and chewing of cruciferous vegetables releases the thioglucosidase enzyme myrosinase, which degrades glucosinolates to isothiocyanates and other minor metabolites. Cooking of...

article 2002

document

Alternatives to animal testing

Havenaar, R. (author), TNO Voeding (author)

conference paper 2002

document

Folate bioaccessibility from fortified dairy products and the effect of folate binding protein on folate retention studied in a dynamic in vitro gastro-intestinal model

Verwei, M. (author), Arkbåge, K. (author), Havenaar, R. (author), van den Berg, H. (author), Witthöft, C. (author), Schaafsma, G. (author), TNO Voeding (author)

conference paper 2002

document

Digestibility of potential allergens in TIM-1

Havenaar, R. (author), Rodrigues, S. (author), Fournier, M. (author), Guillet, C. (author), Penninks, A. (author), TNO Voeding (author)

conference paper 2002

document

FIDO: An alternative to invasive animal research

Havenaar, R. (author), TNO Voeding (author)

article 2002

document

Application of the TNO in vitro gastrointestinal model for research on food (anti)-mutagens

Krul, C.A.M. (author), Luiten-Schuitema, A. (author), Baan, R. (author), Verhagen, H. (author), Havenaar, R. (author)

article 2001

document

Lactulose: A review on effects, clinical results, and safety aspects in relation to its influence on the colonic environment

Havenaar, R. (author), van Dokkum, W. (author), TNO Voeding (author)

bookPart 2001

document

Antimutagenic activity of green tea and black tea extracts studied in a dynamic in vitro gastrointestinal model

Krul, C.A.M. (author), Luiten-Schuite, A. (author), Tenfelde, A. (author), van Ommen, B. (author), Verhagen, H. (author), Havenaar, R. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

An in vitro gastrointestinal model, which simulates the conditions in the human digestive tract, was used to determine potential antimutagenic activity of extracts of black tea and green tea. In this paper, results are presented on the availability for absorption of potential antimutagenic compounds present in tea and on the influence of the...

article 2001

document

Biologie en zoötechniek

Havenaar, R. (author), Ritskes-Hoitinga, J. (author), Meijer, J.C. (author), Zwart, P. (author), TNO Voeding (author)

bookPart 2001

document

Application of a dynamic in vitro gastro-intestinal tract model to study the antimutagenic activity of green tea and black tea extracts.

Krul, C.A.M. (author), Luiten-Schuite, A. (author), Tenfelde, A. (author), van Ommen, B. (author), Verhagen, H. (author), Havenaar, R. (author), TNO Voeding (author)

article 2001