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Use of a gastro-intestinal model and gastroplus[tm] for the prediction of in vivo performance

Naylor, T.A. (author), Connolly, P.C. (author), Martini, L.G. (author), Elder, D.P. (author), Minekus, M. (author), Havenaar, R. (author), Zeijdner, E. (author), TNO Kwaliteit van Leven (author)

article 2006

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Research goals for folate and related B vitamin in Europe

Finglas, P.M. (author), de Meer, K. (author), Molloy, A. (author), Verhoef, P. (author), Pietrzik, K. (author), Powers, H.J. (author), van der Straeten, D. (author), Jägerstad, M. (author), Varela-Moreiras, G. (author), van Vliet, T. (author), Havenaar, R. (author), Buttriss, J. (author), Wright, A.J.A. (author), TNO Kwaliteit van Leven (author)

In the past decade, the understanding of folate bioavailability, metabolism and related health issues has increased, but several problems remain, including the difficulty of delivering the available knowledge to the populations at risk. Owing to the low compliance of taking folic acid supplements, for example, among women of child-bearing age...

article 2006

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Predicted serum folate concentrations based on in vitro studies and kinetic modeling are consistent with measured folate concentrations in humans

Verwei, M. (author), Freidig, A.P. (author), Havenaar, R. (author), Groten, J.P. (author), TNO Kwaliteit van Leven (author)

The nutritional quality of new functional or fortified food products depends on the bioavailability of the nutrient(s) in the human body. Bioavailability is often determined in human intervention studies by measurements of plasma or serum profiles over a certain time period. These studies are time and cost consuming and often appear to lack an...

article 2006

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Effect of folate-binding protein on intestinal transport of folic acid and 5-methyltetrahydrofolate across Caco-2 cells

Verwei, M. (author), van den Berg, H. (author), Havenaar, R. (author), Groten, J.P. (author), TNO Defensie en Veiligheid TNO Kwaliteit van Leven (author)

Background: Milk products are a potential matrix for fortification with synthetic folic acid or natural 5-methyltetrahydrofolate (5-CH 3-H4folate) to enhance the daily folate intake. In milk, folate occurs bound to folatebinding proteins (FBP). Our previous studies with an in vitro gastrointestinal model showed that 70% of the initial FBP...

article 2005

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The effect of folate-binding proteins on bioavailability of folate from milk products

Verwei, M. (author), Arkbåge, K. (author), Groten, J.P. (author), Witthöft, C. (author), van den Berg, H. (author), Havenaar, R. (author), TNO Defensie en Veiligheid TNO Kwaliteit van Leven (author)

article 2005

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Effect of partially hydrolyzed guar gum (PHGG) on the bioaccessibility of fat and cholesterol

Minekus, M. (author), Jelier, M. (author), Xiao, J.-Z. (author), Kondo, S. (author), Iwatsuki, K. (author), Kokubo, S. (author), Bos, M. (author), Dunnewind, B. (author), Havenaar, R. (author), TNO Kwaliteit van Leven (author)

The Addition of a compound that lowers the intestinal uptake of fat and cholesterol might be an interesting strategy to reduce the risk of vascular disease. Partially hydrolyzed guar gum (PHGG) has been shown to have this effect in healthy volunteers after intake of a yogurt drink with 3 to 6% PHGG. In the present study a yogurt drink with 3%...

article 2005

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A dynamic artificial gastrointestinal system for studying the behavior of orally administered drug dosage forms under various physiological conditions

Blanquet, S. (author), Zeijdner, E. (author), Beyssac, E. (author), Meunier, J.-P. (author), Denis, S. (author), Havenaar, R. (author), Alric, M. (author), TNO Voeding (author)

Purpose. The purpose of this study was to demonstrate the potential of a dynamic, multicompartmental in vitro system simulating the human stomach and small intestine (TIM-1) for studying the behavior of oral drug dosage forms under various physiological gastrointestinal conditions. Methods. Two model drug compounds were studied in TIM-1: a...

article 2004

document

The Binding of Folic Acid and 5-Methyltetrahydrofolate to Folate-Binding Proteins during Gastric Passage Differs in a Dynamic in Vitro Gastrointestinal Model

Verwei, M. (author), Arkbåge, K. (author), Mocking, H. (author), Havenaar, R. (author), Groten, J. (author), TNO Voeding (author)

Despite its low natural folate concentration, milk is responsible for 10-15% of the daily folate intake in countries with a high dairy consumption. Milk products can be considered as a potential matrix for folate fortification, e.g., with synthetic folic acid, to enhance the daily intake of folate. In untreated milk, the natural folate, 5...

article 2004

document

Evaluation of the intestinal absorption of deoxynivalenol and nivalenol by an in vitro gastrointestinal model, and the binding efficacy of activated carbon and other adsorbent materials

Avantaggiato, G. (author), Havenaar, R. (author), Visconti, A. (author), TNO Voeding (author)

In vitro screening of 14 adsorbent materials, including some commercial products used to detoxify Fusarium-mycotoxins, were tested in the pH range of 3-8 for deoxynivalenol (DON)- and nivalenol (NIV)-binding ability. Only activated carbon showed to be effective with binding capacities of 35.1 μmol and 8.8 μmol DON and NIV/g adsorbent,...

article 2004

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In vitro techniques for intestinal health

Venema, K. (author), van de Sandt, J.J.M. (author), Havenaar, R. (author), TNO Voeding (author)

article 2004

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An in vitro model of the large intestine to study bioconversion of compounds

Venema, K. (author), Krul, C.A.M. (author), Havenaar, R. (author), TNO Voeding (author)

article 2004

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In vitro techniques and ex vivo systems for studying the metabolism of intestinal bacteria

Venema, K. (author), van de Sandt, J.J.M. (author), Havenaar, R. (author), TNO Voeding (author)

article 2004

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Intragastric formation and modulation of N-nitrosodimethylamine in a dynamic in vitro gastrointestinal model under human physiological conditions

Krul, C.A.M. (author), Zeilmaker, M.J. (author), Schothorst, R.C. (author), Havenaar, R. (author), TNO Voeding (author)

Human exposure to carcinogenic N-alkylnitrosamines can occur exogenously via food consumption or endogenously by formation of these compounds through nitrosation of amine precursors. Information on the intragastric formation of NDMA from complex mixtures of precursors and inhibitors in humans is not available. In this study the formation of N...

article 2004

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The use of a dynamic in vitro model of the gastrointestinal tract (TIM) in studying mycotoxin adsorbents

Zeijdner, E.E. (author), Avantaggiato, G. (author), Sidler, S. (author), Escribano, F. (author), Visconti, A. (author), Havenaar, R. (author), TNO Voeding (author)

article 2004

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Advanced in vitro dissolution system to study food effects and underlying drug-nutrient interactions

Zeijdner, E.E. (author), Witkamp, R. (author), Venema, K. (author), Minekus, M. (author), Havenaar, R. (author), TNO Voeding (author)

article 2004

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Evaluation of potentional mutagenic and antimutagenic properties of foods in dynamic in vitro models of the gastrointestinal tract

Havenaar, R. (author), Krul, C.A.M. (author), Schothorst, R. (author), Venema, K. (author), Humblot, C. (author)

conference paper 2003

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Efficacy of a natural magnesium smectite against aflatoxin B1 and zearalenone tested in a dynamic in vitro model of the gastric and small intestine simulating the pig

Zeijdner, E.E. (author), Sidler, S. (author), Gómez, G. (author), Havenaar, R. (author), Escribano, F. (author), TNO Voeding (author)

conference paper 2003

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Biomarkers for intestinal health: Effect of inulin and its microbial fermentation products on the metabolic profile of cultured enterocytes

Venema, K. (author), van Nesselrooij, J. (author), Lamers, R.J. (author), Havenaar, R. (author), van de Sandt, J. (author), TNO Voeding (author)

conference paper 2003

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Advanced in vitro models of the gastro-intestinal tract: Novel tools to study functionality of dietary fibres

Venema, K. (author), Minekus, M. (author), Havenaar, R. (author), TNO Voeding (author)

conference paper 2003

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Folate bioaccessibility from fortifief dairy products and effect of folate binding protein studied in a dynamic in vitro gastrointestinal model

Havenaar, R. (author), Verwei, M. (author), Arkbåge, K. (author), Witthöft, C.M. (author), TNO Voeding (author)

conference paper 2003