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Bellmann, S. (author), Krishnan, S. (author), de Graaf, A. (author), de Ligt, R.A. (author), Pasman, W.J. (author), Minekus, M. (author), Havenaar, R. (author)The expected increase of global obesity prevalence makes it necessary to have information about the effects of meal intakes on the feeling of appetite. Because human clinical studies are time and cost intensive, there is a need for a reliable alternative. The aim of this study was to develop and evaluate an in vitro-in silico technology to...article 2019
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Verwei, M. (author), Minekus, M. (author), Zeijdner, E. (author), Schilderink, R. (author), Havenaar, R. (author)Pharmaceutical research needs predictive in vitro tools for API bioavailability in humans. We evaluated two dynamic in vitro gastrointestinal models: TIM-1 and tiny-TIM. Four low-soluble APIs in various formulations were investigated in the TIM systems under fasted and fed conditions. API small-intestinal bioaccessibility profiles were evaluated...article 2016
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Havenaar, R. (author), de Jong, A. (author), Koenen, M.E. (author), van Bilsen, J. (author), Janssen, A.M. (author), Labij, E. (author), Westerbeek, H.J.M. (author)Aim of this study was to investigate the digestion of transglutaminase cross-linked caseinate (XLC) versus native caseinate (NC) in solution and in cheese spread under digestive conditions for adults and children mimicked in a gastrointestinal model. Samples were collected for gel electrophoresis and nitrogen analysis. The results showed no...article 2013
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Havenaar, R. (author), Anneveld, B. (author), Hanff, L.M. (author), de Wildt, S.N. (author), de Koning, B.A.E. (author), Mooij, M.G. (author), Lelieveld, J.P.A. (author), Minekus, M. (author)There is a need for information on the bioavailability in pediatric patients of drugs from manipulated dosage forms when applied in combination with food and/or co-medication under realistic daily practice circumstances. We describe the development, validation and application of a dynamic, computer-controlled in vitro system mimicking the...article 2013
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Björck, I. (author), Östman, E. (author), Kristensen, M. (author), Mateo Anson, N. (author), Price, R.K. (author), Haenen, G.R.M.M. (author), Havenaar, R. (author), Bach Knudsen, K.E. (author), Frid, A. (author), Mykkänen, H. (author), Welch, R.W. (author), Riccardi, G. (author)Epidemiological studies have linked whole grain intake to the prevention of the metabolic syndrome, obesity and associated chronic diseases such as CVD and T2D. The Nutrition module within the HEALTHGRAIN project, included 10 partners and undertook in vitro, animal and human in vivo studies with the overall aims of elucidating the components and...article 2012
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Mateo Anson, N. (author), Aura, A.-M. (author), Selinheimo, E. (author), Mattila, I. (author), Poutanen, K. (author), van den Berg, R. (author), Havenaar, R. (author), Bast, A. (author), Haenen, G.R.M.M. (author)Whole grain consumption has been linked to a lower risk of metabolic syndrome, which is normally associated with a lowgrade chronic inflammation. The benefits of whole grain are in part related to the inclusion of the bran, rich in phenolic acids and fiber. However, the phenols are poorly bioaccessible from the cereal matrix. The aim of the...article 2011
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Havenaar, R. (author)This review tries to find a scientific answer on the following two questions: (1) to what extent do we understand the specific role of colonic microbial metabolites, especially short-chain fatty acids (SCFA), in maintaining the health status and prevention of diseases of the colon and the host; (2) to what extent can we influence or even control...article 2011
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Mateo Anson, N. (author), Havenaar, R. (author), Vaes, W. (author), Coulier, L. (author), Venema, K. (author), Selinheimo, E. (author), Bast, A. (author), Haenen, G.R.M.M. (author)The health benefits of whole grain consumption can be partly attributed to the inclusion of the bran or outer-layers of the grain rich in dietary fibre. Fibre is fermented in the colon, leading to the production of beneficial metabolites, such as short-chain fatty acids (SCFA). The effect of five different types of bread on the SCFA production...article 2011
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- Zhu, Y. (author), Havenaar, R. (author), Venema, K. (author) article 2011
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Mateo Anson, N. (author), Havenaar, R. (author), Bast, A. (author), Haenen, G.R.M.M. (author), TNO Kwaliteit van Leven (author)Wholegrain consumption is associated with several health benefits, in contrast to the consumption of refined grains. This can partly be related to the antioxidant compounds in the outer parts of the grain kernel. The bioaccessibility of these antioxidant compounds from the wholegrain matrix during gastrointestinal digestion is crucial for their...article 2010
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Hemery, Y.M. (author), Anson, N.M. (author), Havenaar, R. (author), Haenen, G.R.M.M. (author), Noort, M.W.J. (author), Rouau, X. (author), TNO Kwaliteit van Leven (author)This study evaluated the potential of using ultra-fine grinding and electrostatic separation of wheat bran as methods to improve the bioaccessibility of para-coumaric acid (pCA), sinapic acid (SA) and ferulic acid (FA) from bran-rich breads. Bran fractions were produced and used to bake white bread, whole-grain bread, and seven different bran...article 2010
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- Mateo Anson, N. (author), Selinheimo, E. (author), Aura, A.M. (author), Havenaar, R. (author), Bast, A. (author), Haenen, G.R.M.M. (author) conference paper 2010
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Mateo Anson, N. (author), van den Berg, R. (author), Havenaar, R. (author), Bast, A. (author), Haenen, G.R.M.M. (author), TNO Kwaliteit van Leven (author)Epidemiological studies have linked whole grain consumption to prevention of several chronic diseases. Whole grain is a source of important phytochemicals, such as ferulic acid (FA). FA is the most abundant phenolic and major contributor to the in vitro antioxidant capacity of wheat grain. Several studies have reported highly variable results on...article 2009
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Mateo Anson, N. (author), Selinheimo, E. (author), Havenaar, R. (author), Aura, A.-M. (author), Mattila, I. (author), Lehtinen, P. (author), Bast, A. (author), Poutanen, K. (author), Haenen, G.R.M.M. (author), TNO Kwaliteit van Leven (author)Ferulic acid (FA) is the most abundant phenolic compound in wheat grain, mainly located in the bran. However, its bioaccessibility from the bran matrix is extremely low. Different bioprocessing techniques involving fermentation or enzymatic and fermentation treatments of wheat bran were developed aiming at improving the bioaccessibility of...article 2009
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Mitea, C. (author), Havenaar, R. (author), Wouter Drijfhout, J. (author), Edens, L. (author), Dekking, L. (author), Koning, F. (author), Dekking, E.H.A. (author), TNO Kwaliteit van Leven (author)Background: Coeliac disease is caused by an immune response to gluten. As gluten proteins are proline rich they are resistant to enzymatic digestion in the gastrointestinal tract, a property that probably contributes to the immunogenic nature of gluten. Aims: This study determined the efficiency of gluten degradation by a post-proline cutting...article 2008
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Mateo Anson, N. (author), van den Berg, R. (author), Havenaar, R. (author), Bast, A. (author), Haenen, G.R.M.M. (author), TNO Kwaliteit van Leven (author), KvL (author)Grain is an important source of phytochemicals, which have potent antioxidant capacity. They have been implicated in the beneficial health effect of whole grains in reducing cardiovascular disease and type 2 diabetes. The aim of the present study was to identify the most important antioxidant fractions of wheat grain. It was found that the...article 2008
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- TNO Kwaliteit van Leven (author), Mateo Anson, N. (author), Berg, R.V.D. (author), Havenaar, R. (author), Haenen, G. (author), Bast, A. (author) article 2008
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Avantaggiato, G. (author), Havenaar, R. (author), Visconti, A. (author), TNO Kwaliteit van Leven (author)A laboratory model, set to simulate the in vivo conditions of the porcine gastrointestinal tract, was used to study the small intestinal absorption of several mycotoxins and the effectiveness of Standard Q/FIS (a carbon/aluminosilicate-based product) in reducing mycotoxin absorption when added to multitoxin-contaminated diets. Mycotoxins were...article 2007
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Lankhorst, C. (author), Tran, Q.D. (author), Havenaar, R. (author), Hendriks, W.H. (author), van der Poel, A.F.B. (author), TNO Kwaliteit van Leven (author)A 3 × 2 × 2 factorial trial was designed to investigate the effect of different extrusion conditions and product parameters on the nutritional quality as determined by a number of in vitro measurements (e.g. reactive lysine, and starch gelatinization degree) as well as physical quality of the kibble (durability and hardness) of a canine diet....article 2007
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Lankhorst, C. (author), Tran, Q.D. (author), Havenaar, R. (author), Hendriks, W.H. (author), van der Poel, A.F.B. (author), TNO Kwaliteit van Leven (author)Commercially available dry dog foods are often manufactured using extrusion cooking. Normal extrusion conditions can promote Maillard reactions involving the amino acid lysine. This non-enzymatic browning reaction occurs between a carbonyl group and an amino group in a diet. This study investigated the influence of a number of extrusion...article 2006