Dewey, F.E. (author), Gusarova, V. (author), Dunbar, R.L. (author), O'Dushlaine, C. (author), Schurmann, C. (author), Gottesman, O. (author), McCarthy, S. (author), van Hout, C.V. (author), Bruse, S. (author), Dansky, H.M. (author), Leader, J.B. (author), Murray, M.F. (author), Ritchie, M.D. (author), Kirchner, H.L. (author), Habegger, L. (author), Lopez, A. (author), Penn, J. (author), Zhao, A. (author), Shao, W. (author), Stahl, N. (author), Murphy, A.J. (author), Hamon, S. (author), Bouzelmat, A. (author), Zhang, R. (author), Shumel, B. (author), Pordy, R. (author), Gipe, D. (author), Herman, G.A. (author), Sheu, W.H.H. (author), Lee, I.T. (author), Liang, K.W. (author), Guo, X. (author), Rotter, J.I. (author), Chen, Y.I. (author), Kraus, W.E. (author), Shah, S.H. (author), Damrauer, S. (author), Small, A. (author), Rader, D.J. (author), Wulff, A.B. (author), Nordestgaard, B.G. (author), Tybjærg-Hansen, A. (author), van den Hoek, A.M. (author), Princen, H.M.G. (author), Ledbetter, D.H. (author), Carey, D.J. (author), Overton, J.D. (author), Reid, J.G. (author), Sasiela, W.J. (author), Banerjee, P. (author), Shuldiner, A.R. (author), Borecki, I.B. (author), Teslovich, T.M. (author), Yancopoulos, G.D. (author), Mellis, S.J. (author), Gromada, J. (author), Baras, A. (author) Background Loss-of-function variants in the angiopoietin-like 3 gene (ANGPTL3) have been associated with decreased plasma levels of triglycerides, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol. It is not known whether such variants or therapeutic antagonism of ANGPTL3 are associated with a reduced risk...
article 2017