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Brok, H.P.M. (author), Tekoppele, J.M. (author), Hakimi, J. (author), Kerwin, J.A. (author), Nijenhuist, E.M. (author), de Groot, C.W. (author), Bontrop, R.E. (author), Hart 't, B.A. (author), Gaubius Instituut (author)CIA in the rhesus monkey is an autoimmune-based polyarthritis with inflammation and erosion of synovial joints that shares various features with human rheumatoid arthritis (RA). The close phylogenetic relationship between man and rhesus monkey makes the model very suitable for preclinical safety and efficacy testing of new therapeutics with...article 2001
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- Brok, H.P.M. (author), TeKoppele, J.M. (author), Hakimi, J. (author), Kerwin, A. (author), Nijenhuis, E.M. (author), de Groot, C.W. (author), Bontrop, R.E. (author), 't Hart, B.A. (author), Gaubius Instituut (author) article 2001
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't Hart, B.A. (author), Bank, R.A. (author), de Roos, J.A.D.M. (author), Brok, H. (author), Jonker, M. (author), Theuns, H.M. (author), Hakimi, J. (author), Koppele, J.M.Te. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The objective of this study was to analyse parameters in rhesus monkey collagen-induced arthritis (CIA) with which the inflammation and destruction of the joints can be described in quantitative terms. CIA was induced in genetically susceptible and resistant monkeys, which can be distinguished on the basis of the dominant resistance marker Mamu...article 1998