Cytogenetic findings in mouse multiple myeloma and Waldenström's macroglobulinemia

Multiple myeloma (MM) and Waldenström's macroglobulinemia-like lymphoma (MW) appear spontaneously in C57BL/KaLwRij mice at a frequency of 0.5% and 0.2%, respectively. They can readily be propagated by intravenous transfer of mainly bone marrow or spleen cells into syngeneic recipients. Previous studies demonstrated that these mouse malignant...

Simultaneous occurrence of acute monoblastic leukemia and an abnormal B-cell clone with both cell types characterized by specific cytogenetic and immunological markers

2 different, unrelated, abnormal clones of cells were found in a patient with acute leukemia, each clone being characterized by specific cytogenetic abnormalities and a distinct immunological phenotype. Bone marrow morphology and cytochemistry indicated an acute monoblastic leukemia, a diagnosis supported by the finding of a t(9;11) in bone...