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Björck, I. (author), Östman, E. (author), Kristensen, M. (author), Mateo Anson, N. (author), Price, R.K. (author), Haenen, G.R.M.M. (author), Havenaar, R. (author), Bach Knudsen, K.E. (author), Frid, A. (author), Mykkänen, H. (author), Welch, R.W. (author), Riccardi, G. (author)Epidemiological studies have linked whole grain intake to the prevention of the metabolic syndrome, obesity and associated chronic diseases such as CVD and T2D. The Nutrition module within the HEALTHGRAIN project, included 10 partners and undertook in vitro, animal and human in vivo studies with the overall aims of elucidating the components and...article 2012
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Mateo Anson, N. (author), Aura, A.-M. (author), Selinheimo, E. (author), Mattila, I. (author), Poutanen, K. (author), van den Berg, R. (author), Havenaar, R. (author), Bast, A. (author), Haenen, G.R.M.M. (author)Whole grain consumption has been linked to a lower risk of metabolic syndrome, which is normally associated with a lowgrade chronic inflammation. The benefits of whole grain are in part related to the inclusion of the bran, rich in phenolic acids and fiber. However, the phenols are poorly bioaccessible from the cereal matrix. The aim of the...article 2011
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Mateo Anson, N. (author), Havenaar, R. (author), Vaes, W. (author), Coulier, L. (author), Venema, K. (author), Selinheimo, E. (author), Bast, A. (author), Haenen, G.R.M.M. (author)The health benefits of whole grain consumption can be partly attributed to the inclusion of the bran or outer-layers of the grain rich in dietary fibre. Fibre is fermented in the colon, leading to the production of beneficial metabolites, such as short-chain fatty acids (SCFA). The effect of five different types of bread on the SCFA production...article 2011
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Mateo Anson, N. (author), Havenaar, R. (author), Bast, A. (author), Haenen, G.R.M.M. (author), TNO Kwaliteit van Leven (author)Wholegrain consumption is associated with several health benefits, in contrast to the consumption of refined grains. This can partly be related to the antioxidant compounds in the outer parts of the grain kernel. The bioaccessibility of these antioxidant compounds from the wholegrain matrix during gastrointestinal digestion is crucial for their...article 2010
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Hemery, Y.M. (author), Anson, N.M. (author), Havenaar, R. (author), Haenen, G.R.M.M. (author), Noort, M.W.J. (author), Rouau, X. (author), TNO Kwaliteit van Leven (author)This study evaluated the potential of using ultra-fine grinding and electrostatic separation of wheat bran as methods to improve the bioaccessibility of para-coumaric acid (pCA), sinapic acid (SA) and ferulic acid (FA) from bran-rich breads. Bran fractions were produced and used to bake white bread, whole-grain bread, and seven different bran...article 2010
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- Mateo Anson, N. (author), Selinheimo, E. (author), Aura, A.M. (author), Havenaar, R. (author), Bast, A. (author), Haenen, G.R.M.M. (author) conference paper 2010
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Mateo Anson, N. (author), van den Berg, R. (author), Havenaar, R. (author), Bast, A. (author), Haenen, G.R.M.M. (author), TNO Kwaliteit van Leven (author)Epidemiological studies have linked whole grain consumption to prevention of several chronic diseases. Whole grain is a source of important phytochemicals, such as ferulic acid (FA). FA is the most abundant phenolic and major contributor to the in vitro antioxidant capacity of wheat grain. Several studies have reported highly variable results on...article 2009
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Mateo Anson, N. (author), Selinheimo, E. (author), Havenaar, R. (author), Aura, A.-M. (author), Mattila, I. (author), Lehtinen, P. (author), Bast, A. (author), Poutanen, K. (author), Haenen, G.R.M.M. (author), TNO Kwaliteit van Leven (author)Ferulic acid (FA) is the most abundant phenolic compound in wheat grain, mainly located in the bran. However, its bioaccessibility from the bran matrix is extremely low. Different bioprocessing techniques involving fermentation or enzymatic and fermentation treatments of wheat bran were developed aiming at improving the bioaccessibility of...article 2009
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Mateo Anson, N. (author), van den Berg, R. (author), Havenaar, R. (author), Bast, A. (author), Haenen, G.R.M.M. (author), TNO Kwaliteit van Leven (author), KvL (author)Grain is an important source of phytochemicals, which have potent antioxidant capacity. They have been implicated in the beneficial health effect of whole grains in reducing cardiovascular disease and type 2 diabetes. The aim of the present study was to identify the most important antioxidant fractions of wheat grain. It was found that the...article 2008
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van den Berg, R. (author), Haenen, G.R.M.M. (author), van den Berg, H. (author), Bast, A. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)Nuclear factor-κB (NF-κB) is an oxidative stress sensitive transcription factor involved in the regulation of inflammatory genes. Activation of NF-κB results into increased expression of inflammatory genes such as for interleukins, endothelial cell leukocyte adhesion molecules and inducible NO synthase. Our study, with six smokers and 10 non...article 2001
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van den Berg, R. (author), van Vliet, T. (author), Broekmans, W.M.R. (author), Cnubben, N.H.P. (author), Vaes, W.H.J. (author), Roza, L. (author), Haenen, G.R.M.M. (author), Bast, A. (author), van den Berg, H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The potential benefits of a high fruit and vegetable intake on the antioxidant status and on relevant biomarkers of oxidative damage to lipids, proteins and DNA and on (functional) markers of oxidative stress were evaluated. A randomized, free living, open placebo-controlled cross-over trial of 3 wk, with a 2-wk washout period between treatments...article 2001
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- Drent, M. (author), van den Berg, R. (author), Haenen, G.R.M.M. (author), van den Berg, H. (author), Wouters, E.F.M. (author), Bast, A. (author), TNO Voeding (author) article 2001
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Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author), van den Berg, R. (author), Haenen, G.R.M.M. (author), van den Berg, H. (author), Bast, A. (author)There is increasing interest in the involvement of transcription factors, such as of the transcription factor NF-κB (nuclear factor-κB), in the pathogenesis of various diseases. NF-κB is involved in the control of the transcription of a variety of cellular genes that regulate the inflammatory response by the production of cytokines, chemokines,...article 2001
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van den Berg, R. (author), Haenen, G.R.M.M. (author), van den Berg, H. (author), van der Vijgh, W. (author), Bast, A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The antioxidant capacity of a series of structurally related flavonoids is quantified by the amount of ABTS [2,2'-azinobis-(3-ethylbenzthiazoline-6-sulfonate)] radical anions (ABTS(.)-) that is able to react with the flavonoid and expressed as the Trolox equivalent antioxidant capacity (TEAC). To evaluate the predictive value of the TEAC, the...article 2000
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van den Berg, R. (author), Haenen, G.R.M.M. (author), van den Berg, H. (author), Bast, A. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)The TEAC (Trolox equivalent antioxidant capacity) assay is based on scavenging of 2,2'-azinobis-(3- ethylbenzothiazoline-6-sulfonate) radical anions (ABTS(.-)). In this report we describe a modification based on pre-generation of the ABTS radical anions with a thermolabile azo compound, 2,2'-azobis- (2-amidinopropane)HCl (ABAP). This...article 1999
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Bast, A. (author), Haenen, G.R.M.M. (author), van den Berg, R. (author), van den Berg, H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Surprisingly, neither the precise pharmacological effect nor the toxicological profile is usually established for food components. Carotenoids are no exception in this regard. Only limited insight into the pharmacology and toxicology of carotenoids exists. It is known that the antioxidant action of carotenoids is determined by 1. electron...article 1998
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TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author), Ploemen, J.P.H.T.M. (author), Wormhoudt, L.W. (author), Haenen, G.R.M.M. (author), Oudshoorn, M.J. (author), Commandeur, J.N.M. (author), Vermeulen, N.P.E. (author), de Waziers, I. (author), Beaune, P.H. (author), Watabe, T. (author), van Bladeren, P.J. (author)Ethylene dibromide (1,2-dibromoethane, EDB) is metabolized by two routes: a conjugative route catalyzed by glutathione S-transferases (GST) and an oxidative route catalyzed by cytochrome P450 (P450). The GST route is associated with carcinogenicity. An approach is presented to use human purified GST and P450 enzymes to explore the importance of...article 1997
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Hissink, A.M. (author), Oudshoorn, M.J. (author), van Ommen, B. (author), Haenen, G.R.M.M. (author), van Bladeren, P.J. (author)The oxidative biotransformation of 1, 2-dichlorobenzene (1, 2-DCB) was investigated using hepatic microsomes from male Wistar, Fischer-344 and Sprague-Dawley (SD) rats, phenobarbital (PB)- and isoniazid (ISO) pretreated male Wistar rats and from man. In addition, microsomes from cell lines selectively expressing one cytochrome P450 (P4502E1, 1A1...article 1996
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Bast, A. (author), van der Plas, R.M. (author), van den Berg, H. (author), Haenen, G.R.M.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Objective: Beta-carotene has been shown to exhibit a good radical-trapping antioxidant activity in vitro. We were interested to see if dietary β-carotene in combination with various intake levels for vitamin A would also inhibit lipid peroxidation. Design: Sixty male Wistar rats received vitamin A (as retinyl palmitate) for 14 weeks in the diet ...article 1996