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Boessen, R. (author), Lambers Heerspink, H.J. (author), de Zeeuw, D. (author), Grobbee, D.E. (author), Groenwold, R.H.H. (author), Roes, K.C.B. (author)Background: In many therapeutic areas, individual patient markers have been identified that are associated with differential treatment response. These markers include both baseline characteristics, as well as short-term changes following treatment. Using such predictive markers to select subjects for inclusion in randomized clinical trials could...article 2014
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Joosten, M.M. (author), Grobbee, D.E. (author), Verschuren, W.M.M. (author), Hendriks, H.F.J. (author), Beulens, J.W.J. (author), TNO Kwaliteit van Leven (author)Background: It has been suggested that the inverse association between alcohol and type 2 diabetes could be explained by moderate drinkers' healthier lifestyles. Objective: We studied whether moderate alcohol consumption is associated with a lower risk of type 2 diabetes in adults with combined low-risk lifestyle behaviors. Design: We...article 2010
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van Tits, L.J.H. (author), van Heerde, W.L. (author), van der Vleuten, G.M. (author), de Graaf, J. (author), Grobbee, D.E. (author), van de Vijver, L.P.L. (author), Stalenhoef, A.F. (author), Princen, H.M. (author), TNO Kwaliteit van Leven (author)Exogenous radiolabeled annexin A5 is taken up by atherosclerotic tissue. We measured endogenous plasma annexin A5 and circulating oxidized low-density lipoprotein (oxLDL), a biochemical marker of atherosclerosis, in men with either severe angiographically determined coronary stenosis (n = 90) or no or only minor stenosis (n = 96). Men without...article 2007
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van Trijp, M.J.C.A. (author), Beulens, J.W.J. (author), Bos, W.J.W. (author), Uiterwaal, C.S.P.M. (author), Grobbee, D.E. (author), Hendriks, H.F.J. (author), Bots, M.L. (author), TNO Kwaliteit van Leven (author)Background: Light-to-moderate alcohol consumption is associated with a decreased risk of ischemic cardiovascular disease, whereas increased alcohol intake is related to hypertension and intracerebral hemorrhage. We studied the effect of alcohol consumption on the augmentation index (AIx), a measure of arterial wave reflection in a population of...article 2005
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Beulens, J.W.J. (author), Stolk, R.P. (author), van der Schouw, Y.T. (author), Grobbee, D.E. (author), Hendriks, H.F.J. (author), Bots, M.L. (author), TNO Kwaliteit van Leven (author)OBJECTIVE - This study aimed to investigate the relation between alcohol consumption and type 2 diabetes among older women. RESEARCH DESIGN AND METHODS - Between 1993 and 1997, 16,330 women aged 49-70 years and free from diabetes were enrolled in one of the Dutch Prospect-EPIC (European Prospective Study Into Cancer and Nutrition) cohorts and...article 2005
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van den Elzen, A.P. (author), Sierksma, A. (author), Oren, A. (author), Vos, L.E. (author), Witteman, J.C. (author), Grobbee, D.E. (author), Hendriks, H.F. (author), Uiterwaal, C.S. (author), Bots, M.L. (author), TNO Kwaliteit van Leven (author)Background: Moderate alcohol consumption has been shown to protect against cardiovascular disease. Aortic stiffness can be regarded as a marker of cardiovascular disease risk. Previously we have shown an inverse to J-shaped association between alcohol intake and aortic stiffness in middle-aged and elderly men and postmenopausal women. Objective:...article 2005
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Sierksma, A. (author), Sarkola, T. (author), Eriksson, C.J.P. (author), van der Gaag, M.S. (author), Grobbee, D.E. (author), Hendriks, H.F.J. (author), TNO Voeding (author)Background: Moderate alcohol consumption is inversely associated with cardiovascular diseases. Changes in hormone levels might in part help explain the positive health effect. This study was performed to examine the effect of moderate alcohol consumption on plasma dehydroepiandrosterone sulfate (DHEAS), testosterone, and estradiol levels....article 2004
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Sierksma, A. (author), Patel, H. (author), Ouchi, N. (author), Kihara, S. (author), Funahashi, T. (author), Heine, R.J. (author), Grobbee, D.E. (author), Kluft, C. (author), Hendriks, H.F.J. (author), TNO Preventie en Gezondheid (author)OBJECTIVE - Epidemiological studies suggest that moderate alcohol consumers have enhanced insulin sensitivity and a reduced risk of type 2 diabetes. Adiponectin, an adipocyte-derived plasma protein, has been found to be negatively associated with adiposity and positively associated with insulin sensitivity. Moderate alcohol consumption may...article 2004
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Sierksma, A. (author), Grobbee, D.E. (author), Hendriks, H.F.J. (author), TNO Preventie en Gezondheid (author)This chapter focuses on the vascular and biochemical effects of moderate alcohol consumption and the mechanisms of protection against cardiovascular disease. Cardiovascular disease (CVD), including coronary heart disease, cerebrovascular disease, and peripheral vascular disease, is the leading cause of morbidity and mortality in the Western...bookPart 2004
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Sierksma, A. (author), Lebrun, C.E.I. (author), van der Schouw, Y.T. (author), Grobbee, D.E. (author), Lamberts, S.W.J. (author), Hendriks, H.F.J. (author), Bots, M.L. (author), TNO Voeding (author)Objective-Moderate alcohol consumption has been postulated to be cardioprotective. Such an effect might be reflected in large-artery properties, such as arterial stiffness and wave reflections. Methods and Results-Three hundred seventy-one healthy postmenopausal women aged 50 to 74 years were sampled from a population-based study. Alcohol intake...article 2004
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Sierksma, A. (author), Muller, M. (author), van der Schouw, Y.T. (author), Grobbee, D.E. (author), Hendriks, H.F.J. (author), Bots, M.L. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)Objective: Moderate alcohol consumption has been proposed to be anti-atherogenic and protect against coronary heart disease. Arterial stiffness provides a summary measure of atherosclerotic arterial damage and cardiovascular risk. A vascular protective effect of moderate alcohol consumption would be reflected in an inverse association between...article 2004
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Sierksma, A. (author), Vermunt, S.H.F. (author), Lankhuizen, I.M. (author), van der Gaag, M.S. (author), Scheek, L.M. (author), Grobbee, D.E. (author), van Tol, A. (author), Hendriks, H.F.J. (author), TNO Voeding (author)Background: Alcohol consumption is associated with increased high-density lipoprotein (HDL) cholesterol levels. One of the main antiatherogenic functions of HDL is reverse cholesterol transport. Three early steps of reverse cholesterol transport are (1) cellular cholesterol efflux, (2) plasma cholesterol esterification (EST), and (3) cholesteryl...article 2004
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Uiterwaal, C.S.P.M. (author), Grobbee, D.E. (author), Sakkers, R.J.B. (author), Helders, P.J.M. (author), Bank, R.A. (author), Engelbert, R.H.H. (author), TNO Preventie en Gezondheid (author)Background. Blood pressure, particularly pulse pressure, is associated with arterial wall stiffness, but little is known about its relation to stiffness of other parts of the body. We examined the extent to which blood pressure levels in young healthy children are related to stiffness of various tissues. Methods. In November 2000, we studied 95...article 2003
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- Sierksma, A. (author), Hulshof, K.F.A.M. (author), Grobbee, D.E. (author), Hendriks, H.F.J. (author), TNO Voeding (author) bookPart 2003
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Sierksma, A. (author), van der Gaag, M.S. (author), Grobbee, D.E. (author), Hendriks, H.F.J. (author)1. The present study investigated the acute and chronic effect of dinner with alcoholic beverages on serum nitric oxide (NO) metabolites, namely nitrate and nitrite (NOx), in 11 healthy, non-smoking middle-aged men. 2. In a randomized, diet-controlled, cross-over trial, subjects consumed dinner with four glasses of red wine, beer, spirits (Dutch...article 2003
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TNO Biomedical Instrumentation (author), van Popele, N.M. (author), Bos, W.J.W. (author), de Beer, N.A.M. (author), van der Kuip, D.A.M. (author), Hofman, A. (author), Grobbee, D.E. (author), Witteman, J.C.M. (author)Oscillometric blood pressure devices tend to overestimate systolic blood pressure and underestimate diastolic blood pressure compared with sphygmomanometers. Recent studies indicate that discrepancies in performance between these devices may differ between healthy and diabetic subjects. Arterial stiffness in diabetics could be the underlying...article 2000
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- van de Vijver, L.P.L. (author), Kardinaal, A.F.M. (author), van Duyvenvoorde, W. (author), Kruijssen, D.A.C.M. (author), Grobbee, D.E. (author), van Poppel, G. (author), Princen, H.M.G. (author) article 1999
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van de Vijver, L.P.L. (author), Kardinaal, A.F.M. (author), van Duyvenvoorde, W. (author), Kruijssen, D.A.C.M. (author), Grobbee, D.E. (author), van Poppel, G. (author), Princen, H.M.G. (author), TNO Preventie en Gezondheid (author)Evidence has accumulated for oxidative modification of low-density lipoproteins (LDL) to play an important role in the atherogenic process. Therefore, we investigated the relation between susceptibility of LDL to oxidation and risk of peripheral atherosclerosis among 249 men between 45 and 80 years of age. The ankle-arm index was calculated for...article 1999
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Klipstein-Grobusch, K. (author), Witteman, J.C.M. (author), den Breeijen, J.H. (author), Goldbohm, R.A. (author), Hofman, A. (author), de Jong, P.T.V.M. (author), Pols, H.A. (author), Grobbee, D.E. (author)Objective: Description and application of an adapted semiquantitative food frequency questionnaire (SFFQ) for dietary assessment in the elderly population of the Rotterdam Study. Design: Dietary assessment consisting of a two-step approach was performed in 5434 participants (2225 men, 3029 women) of the Rotterdam Study from 1990 to 1993, a...article 1999
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- Klipstein-Grobusch, K. (author), Geleijnse, J.M. (author), van Breeijen, J.H. (author), Boeing, H. (author), Hofman, A. (author), Grobbee, D.E. (author), Witteman, J.C.M. (author) article 1999