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- van den Berg, K.J. (author), Gramsbergen, J.B.P. (author), Hoogendijk, E.M.G. (author), Lammers, J.H.C.M. (author), Sloot, W.N. (author), Kulig, B.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author) conference paper 1995
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Sloot, W.N. (author), Gramsbergen, J.B.P. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)It has been suggested that salicylate (SA) hydroxylation can be used to detect hydroxyl radical formation in vivo. Here we describe a rapid and sensitive HPLC method using ultraviolet absorbance (UV) and electrochemical detection (EC) to detect SA (UV), its hydroxylated adducts 2,3- and 2,5- dihydroxybenzoic acids (DHBA) and catechol in...article 1995
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Sloot, W.N. (author), Gramsbergen, J.B.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The present study provides evidence for anterograde axonal transport of managanese (Mn) in the basal ganglia. Microinjections of 54Mn into rat substantia nigra or stratum revealed region-specific accumulation and retention of the isotope in globus pallidus, striatum, thalamus and substantia nigra for up to a least 48 or 72 h respectively. Within...article 1994
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- de Knegt, R.J. (author), Gramsbergen, J.B.P. (author), Schalm, S.W. (author), Centraal Instituut voor Voedingsonderzoek TNO (author) article 1994
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Sloot, W.N. (author), van der Sluijs-Gelling, A.J. (author), Gramsbergen, J.B.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Regional 45Ca2+ accumulation and analysis of monoamines and metabolites in dissected tissues were used to localize, quantify, and characterize brain damage after intracerebral injections of Mn2+ into striatum and hippocampus. The specificity of Mn2+-induced lesions is described in relation to brain damage produced by local Fe2+ or 6-...article 1994
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- van Nesselrooij, J.H.J. (author), Kuper, C.F. (author), Feron, V.J. (author), van den Berg, K.J. (author), Hoogendijk, E.M.G. (author), Kulig, B.M. (author), Cassee, F.R. (author), Groten, J.P. (author), Roggeband, R. (author), van den Berg, P.T.M. (author), Steenwinkel, M-J.S.T. (author), van Delft, J.H.M. (author), Baan, R.A. (author), Rompelberg, J.J.M. (author), van den Heuvel, P.D. (author), Bruijntjes-Rozier, T.C.D.M. (author), Leeman, R.R. (author), Verhagen, H. (author), van de Sandt, J.J.M. (author), Bos, T.A. (author), Rutten, A.A.J.J.L. (author), Sloot, W.N. (author), Gramsbergen, J.B.P. (author), Velthuis-te Wierik, E.J.M. (author), de Vogel, N. (author), Wolterbeek, A.P.M. (author), Schoevers, E.J. (author), van Moorsel, C.J.A. (author) article 1994
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- Gramsbergen, J.B.P. (author), van der Sluijs-Gelling, A.J. (author), Centraal Instituut voor Voedingsonderzoek TNO Medisch Biologisch Laboratorium TNO (author) article 1993
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van den Berg, K.J. (author), Gramsbergen, J.B.P. (author), Medisch Biologisch Laboratorium TNO Centraal Instituut voor Voedingsonderzoek TNO (author)Chemicals/CAS: calcium, 7440-70-2; kainic acid, 487-79-6; Biological Markers; Calcium, 7440-70-2; Glial Fibrillary Acidic Protein; Kainic Acid, 487-79-6; Neurotoxinsarticle 1993