document

Intravascular coagulation: A common phenomenon in minor experimental head injury

van der Sande, J.J. (author), Emeis, J.J. (author), Lindeman, J. (author), Gezondheidsorganisatie TNO Gaubius Instituut TNO (author)

Fibrin microthrombi were demonstrated by an immunoenzymehistochemical method in the small blood vessels of the lung and, to a lesser extent, in the brain in rats after minor experimental head injury. It was concluded that intravascular coagulation is a common phenomenon in head injury.

article 1981

document

Enhancement of in vitro plasma fibrinolysis by sulphated polysaccharides

Kluft, C. (author), Gezondheidsorganisatie TNO Gaubius Instituut TNO (author)

conference paper 1980

document

Plasminogen proactivators and activators in human plasma: Factor XII-dependent fibrinolysis

Kluft, C. (author), Gezondheidsorganisatie TNO Gaubius Instituut TNO (author)

Factor XII-prekallikrein dependent processes contribute to the fibrinolytic activity of plasma, Evidence for the occurrence of a plasminogen proactivator separate from factor XII, factor XI and prekallikrein is summarized.

conference paper 1980

document

New prospects in the activation of fibrinolysis

Kluft, C. (author), Gezondheidsorganisatie TNO Gaubius Instituut TNO (author)

bookPart 1980

document

Kontakt-aktivering van stolling, fibrinolyse en het kininesysteem: Bestudering van het centrale enzym kallikreine met chromogene substraten

Kluft, C. (author), Gezondheidsorganisatie TNO Gaubius Instituut TNO (author)

In de vorige edities (Para Medica 1, 2, 3) werd aandacht besteed aan algemene principes en praktische aspekten van chromogene en fluorogene substraten voor de bestudering van bloedstolling en fïbrinolyse. Dit verhaal gaat nader in op de ontwikkeling van een bepaling, namelijk die voor plasma prekallikreine, de centrale komponent in de kontakt...

article 1980

document

Studies on the human vascular plasminogen activator

Gezondheidsorganisatie TNO Gaubius Instituut TNO (author), Allen, R.A. (author)

article 1980

document

C1 inhibitor: The main inhibitor of human plasma kallikrein

Trumpi-Kalshoven, M.M. (author), Kluft, C. (author), Gezondheidsorganisatie TNO Gaubius Instituut TNO (author)

The relative importance of two plasma inhibitors C1 inhibitor and α_2-macroglobulin in the inhibition of plasma kallikrein was studied using the synthetic substrate PPAN. The inhibition of plasma kallikrein by purified inhibitors as well as by normal plasma and inhibitor-depleted plasma was determined. The sensitivity of purified kallikrein,...

conference paper 1979

document

4-methyl-2-oxopentanoate oxidation by rat skeletal-muscle mitochondria

Gezondheidsorganisatie TNO Gaubius Instituut TNO (author), van Hinsbergh, V.W.M. (author), Veerkamp, J.H. (author), Glatz, J.F.C. (author)

1. Oxidative decarboxylation of 4-methyl-2-oxopentanoate (2-oxoisocaproate) by mitochondria of rat skeletal muscle showed biphasic kinetics. Two apparent Km values of 9.1 micronM and 0.78 mM were established. In broken mitochondria the rate of oxidation was lower and only the higher apparent Km value was found. 2. Isovalerylcarnitine inhibited 4...

article 1979

document

Studies on the fibrinolytic system in human plasma: Quantitative determination of plasminogen activators and proactivators

Kluft, C. (author), Gezondheidsorganisatie TNO Gaubius Instituut TNO (author)

Effects due to plasma plasminogen activators and proactivators are usually studied in assay systems where inhibitors influence the activity and where the degree of activation of proactivators is unknown. Quantitative information on activator and proactivator levels in plasma is therefore not available. Studies on the precipitating and activating...

article 1979

document

Voedingsgewoonten en relevante gezondheidsaspecten van bejaarden in een Rotterdamse huisartspraktijk 1971-1975: onderzoek naar voedingsgewoonten, anthropometrische gegevens en klinisch-chemische bevindingen omtrent de status van hemoglobine, ijzer, diverse vitamines en van serum-lipiden

Gezondheidsorganisatie TNO Gaubius instituut TNO (author), Bowles, C.H. (author)

doctoral thesis 1979

document

Radioimmunoassay of pancreatic glucagon

Gezondheidsorganisatie TNO Gaubius instituut TNO (author), Nooijen, W.J. (author)

doctoral thesis 1979

document

On the role of the recipient cell during conjugation in Escherichia coli

Gezondheidsorganisatie TNO Gaubius Instituut TNO (author), Hoekstra, W.P.M. (author), Havekes, A.M. (author)

To study the role of the E. coli recipient cell in conjugation recipient cell mutants deficient in conjugation (Con-) were isolated. Mutants specific for F-type E. coli donor cells (ConF-) and mutants specific deficient in conjugation with I-type donor cells (ConI-) were isolated. Both ConF- and ConI- mutants were blocked in stable mating pair...

article 1979

document

The fibrinolytic response of man to vasoactive drugs measured in arterial blood

Rosing, D.R. (author), Redwood, D.R. (author), Brakman, P. (author), Astrup, T. (author), Epstein, S.E. (author), Gezondheidsorganisatie TNO Gaubius Instituut TNO (author)

To contribute to the elucidation of the modes by which blood fibrinolytic activity is induced the effects of some vasoactive drugs on the fibrinolytic activity in man were studied in samples of arterial blood. No causal relationship could be demonstrated between the vascular and fibrinolytic effects of the vasoactive drugs. Rather, our data...

article 1978

document

Gehoorbeschermingsprogramma: Taak van de Bedrijfsgeneeskundige Dienst

Nederlands instituut voor praeventieve gezondheidszorg TNO Gezondheidsorganisatie TNO Gaubius Instituut TNO (author), Lindeman, J. (author), Hoolboom, H. (author)

other 1978

document

Blood fibrinolysis ; proactivators and activators in human plasma

Gezondheidsorganisatie TNO Gaubius instituut TNO (author), Kluft, C. (author)

doctoral thesis 1978

document

Activators and inhibitors of fibrinolysis in rheumatoid and nonrheumatoid synovial membranes

van de Putte, L.B.A. (author), Noordhoek Hegt, V. (author), Overbeek, T.E. (author), Gezondheidsorganisatie TNO Gaubius Instituut TNO (author)

Histochemical studies of rheumatoid and non‐rheumatoid synovial membranes revealed lowered fibrinolytic activity at sites of chronic inflammatory infiltrates and deposits of fibrin‐like material (FLM). Inhibition of fibrinolysis occurred over these areas and was always inversely related to the fibrinolytic activity. Hence the low fibrinolytic...

article 1977

document

Histochemical studies on vascular fibrinolysis

Gezondheidsorganisatie TNO Gaubius instituut TNO (author), Noordhoek Hegt, V. (author)

doctoral thesis 1977

document

Microthrombose en fibrinolysis: een pathologisch-anatomisch onderzoek

Gezondheidsorganisatie TNO Gaubius instituut TNO (author), Lindeman, J. (author)

doctoral thesis 1976

document

Effect of flufenamate on euglobulin fibrinolysis: Involvement of C1-inactivator

Kluft, C. (author), Brakman, P. (author), Gezondheidsorganisatie TNO Gaubius Instituut TNO (author)

bookPart 1975

document

Resting levels of blood fibrinolysis in hyperlipoproteinemia

Brakman, P. (author), Astrup, T. (author), Levy, R.I. (author), Frederickson, D.S. (author), Gezondheidsorganisatie TNO Gaubius Instituut TNO (author)

To correlate resting levels of blood fibrinolysis with different types of hyperlipidemia, the concentrations of fibrinogen and plasminogen and the euglobulin activity (precipitated at pH 5.9 and assayed on fibrin plates prepared with bovine, plasminogen-rich fibrinogen) were determined in fasting plasma samples from a group of normal controls (...

article 1974