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The effect of inhibitors of the cholesterol synthesis on HMG-CoA reductase activity in the human hepatoma cell line Hep G2

Gezondheidsorganisatie TNO Gaubius Instituut TNO (author), Cohen, L.H. (author), Boogaard, A. (author), Kempen, H.J. (author)

article 1986

document

The apolipoprotein E polymorphism at the DNA-level: abstract

Gezondheidsorganisatie TNO Gaubius Instituut TNO (author), Havekes, L. (author), Smit, M. (author), Klasen, E. (author)

article 1986

document

The postoperative fibrinolytic shutdown: A rapidly reverting acute phase pattern for the fast-acting inhibitor of tissue-type plasminogen activator after trauma

Kluft, C. (author), Verheijen, J.H. (author), Jie, A.F.H. (author), Rijken, D.C. (author), Preston, F.E. (author), Sue-Ling, H.M. (author), Jespersen, J. (author), Aasen, A.O. (author), Gezondheidsorganisatie TNO Gaubius Instituut TNO (author)

The plasma activity level of the recently discovered fast-acting inhibitor of tissue-type plasminogen activator (t-PA) was found to be temporarily increased after surgery, myocardial infarction and severe trauma. Detailed analysis of the postoperative period revealed simultaneously increased t-PA antigen and inhibition and decreased t-PA...

article 1985

document

Diurnal course of the suitability of serum samples obtained from normal subjects and from patients with primary endogenous hypertriglyceridaemia to serve as substrate for milk lipoprotein lipase

Pagano Mirano-Oostdijk, C. (author), Havekes, L. (author), den Boer, P.J. (author), de Wit, E. (author), Terpstra, J. (author), Gezondheidsorganisatie TNO Gaubius Instituut TNO (author)

Serum samples, obtained at various times of the day from four normal subjects and five patients with primary endogenous hypertriglyceridaemia on a carbohydrate-rich diet (meals at 09.00, 13.00 and 17.00 h), were incubated with cows' milk lipoprotein lipase (LPL) to investigate the susceptibility of the triglyceride(TG)-rich lipoprotein fraction...

article 1985

document

Specific targeting of high density lipoproteins to liver hepatocytes by incorporation of a tris-galactoside-terminated cholesterol derivative

Gezondheidsorganisatie TNO Gaubius Instituut TNO (author), van Berkel, T.J.C. (author), Kruijt, J.K. (author), Kempen, H.J.M. (author)

article 1985

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Stimulation of the LDL receptor activity in the human hepatoma cell line Hep G2 by high-density serum fractions

Gezondheidsorganisatie TNO Gaubius instituut TNO (author), Havekes, L. (author), de Wit, E. (author), Verboom, H. (author), Princen, H. (author)

conference paper 1985

document

The influence of glucocorticoid on the fibrinogen messenger RNA content of rat liver in vivo and in hepatocyte suspension culture

Gezondheidsorganisatie TNO Gaubius Instituut TNO (author), Princen, H.M.G. (author)

article 1984

document

Inhibition of tissue type plasminogen activator inhibitor activity by activated protein C: abstract

Gezondheidsorganisatie TNO Gaubius Instituut TNO (author), Bertina, R.M. (author), van Hinsbergh, V.W.M. (author), Emeis, J.J. (author), van Wijngaarden, A. (author)

Abstr. no. 374

article 1984

document

The effect of a water-soluble tris-galactoside terminated cholesterol dertivative on the catabolism of low density lipoprotein: abstract

Gezondheidsorganisatie TNO Gaubius Instituut TNO (author), van Berkel, T.J.C. (author), Kempen, H.J.M. (author)

Abstr. no. 1256

article 1984

document

Secretion of fibrinolysis components and factor VIII related antigen by cultured endothelial cells from human aorta and vena cava: abstract

Gezondheidsorganisatie TNO Gaubius Instituut TNO (author), van Hinsbergh, V.W.M. (author), Sprengers, E.D. (author), Bertina, R.M. (author), Rijken, D.C. (author)

Abstr. no. 378

article 1984

document

Role of endothelial cells and their products in the modification of LDL: abstract

Gezondheidsorganisatie TNO Gaubius Instituut TNO (author), van Hinsbergh, V.W.M. (author), Havekes, L. (author), Scheffer, M. (author)

Abstr. no. 546

article 1984

document

In vivo and in vitro catabolism of native and biologically modified LDL

Gezondheidsorganisatie TNO Gaubius Instituut TNO (author), Nagelkerke, J.F. (author), Havekes, L. (author), van Hinsbergh, V.W.M. (author), van Berkel, T.J.C. (author)

article 1984

document

Diurnal variation of cytosolic fatty acid-binding protein content and of palmitate oxidation in rat liver and heart

Gezondheidsorganisatie TNO Gaubius Instituut TNO (author), Glatz, J.F.C. (author)

article 1984

document

Effect of diet on total cholesterol/HDL-C ratio in patients of Leiden regression trial: abstract

Gezondheidsorganisatie TNO Gaubius Instituut TNO (author), Arntzenius, A.C. (author), Kromhout, D. (author), Kempen, N. (author), van der Velde, E.A. (author), Houtsmuller, U.M.T. (author), van Gent, C.M. (author), Reiber, J.H.C. (author), Barth, J.D. (author)

Abstr. no. 904

article 1983

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Individual levels of plasma histidine-rich glycoprotein (HRG) during the normal menstrual cycle in women on oral contraceptives low in oestrogen

Jespersen, J. (author), Kluft, C. (author), Gezondheidsorganisatie TNO Gaubius Instituut TNO (author)

Histidine-rich glycoprotein (HRG), a 3.8 S-αc2-glycoprotein recently identified as a new flbrinolysis regulating protein, was determined by an electroimmunoassay in samples of plasma collected during one menstrual or hormone cycle in 15 young women and in 11 women using oral contraceptives with 30 μg ethinyl oestradiol and 150 μg levo-norgestrel...

article 1982

document

Coronary lesions and S.lipids before and after 2 years diet in 22 patients: abstract

Gezondheidsorganisatie TNO Gaubius Instituut TNO (author), Arntzenius, A.C. (author), Strikwerda, S. (author), Kempen, N. (author), Bruschke, A.V.G. (author), Reiber, H. (author), Barth, J.D. (author), van Gent, C.M. (author), Houtsmuller, U.M.T. (author), Buis, B. (author)

article 1982

document

A one-step separation of human serum high density lipoproteins 2 and 3 by rate-zonal density gradient ultracentrifugation in a swinging bucket rotor

Gezondheidsorganisatie TNO Gaubius Instituut TNO (author), Groot, P.H.E. (author), Scheek, L.M. (author), Havekes, L. (author), van Noort, W.L. (author), van 't Hooft, F.M. (author)

A method was developed for the separation of the high density lipoprotein subclasses HDL2 and HDL3 from human serum. Six serum samples are fractionated in a single-step ultracentrifugal procedure using the Beckman (SW-40) swinging bucket rotor. The method is based on a difference in flotation rate of the high density lipoprotein subclasses....

article 1982

document

Experimental arterial thrombosis: investigations based on a new microsurgical model for arterial thrombosis in rat aorta

Gezondheidsorganisatie TNO Gaubius instituut TNO (author), van Aken, P.J. (author)

doctoral thesis 1982

document

Generation of fibrinolytic activity in bovine plasma by the combined effects of chloroform and dextran sulphate

Jenks, R.L. (author), Kluft, C. (author), Astrup, T. (author), Gezondheidsorganisatie TNO Gaubius Instituut TNO (author)

Bovine plasma yields fibrinolytically inactive euglobulin fractions, even when prepared in the presence of dextran sulphate. Addition of flufenamate to these solutions only occasionally elicits a slight activity. However, highly fibrinolytic solutions are produced when euglobulins precipitated in the presence of dextran sulphate are exposed to...

article 1981

document

Progress in fibrinolysis

Brommer, E.J.P. (author), Brakman, P. (author), Haverkate, F. (author), Kluft, C. (author), Traas, D. (author), Wijngaards, G. (author), Gezondheidsorganisatie TNO Gaubius Instituut TNO (author)

bookPart 1981