document

The expression of aB-crystallin in multiple sclerosis brains: where, when, how, and why?

Gezondheidsorganisatie TNO Gaubius instituut TNO (author), Bajramovic, J.J. (author)

doctoral thesis 2000

document

Postprandial lipoprotein metabolism in normolipidemic men with and without coronary artery disease

Groot, P.H.E. (author), van Stiphout, W.A. (author), Krauss, X.H. (author), Jansen, H. (author), van Tol, A. (author), van Ramshorst, E. (author), Chin-On, S. (author), Hofman, A. (author), Cresswell, S.R. (author), Havekes, L. (author), Gezondheidsorganisatie TNO Gaubius instituut TNO (author)

article 1991

document

Extrinsic activation of human coagulation factors IX and X on the endothelial surface

Bom, V.J.J. (author), van Hinsbergh, V.W.M. (author), Reinalda-Poot, H.H. (author), Mohanlal, R.W. (author), Bertina, R.M. (author), Gezondheidsorganisatie TNO Gaubius Instituut TNO (author)

In previous kinetic studies, the catalytic efficiency of the activation of human coagulation factors IX and X by factor VIIa in the presence of purified tissue factor apoprotein was found to be essentially equal. These activation reactions were now studied on the surface of human umbilical vein endothelial cells. The cells were stimulated with...

article 1991

document

Heterogeneity of rat liver parenchyma in cholesterol 7α-hydroxylase and bile acids synthesis

Gezondheidsorganisatie TNO Gaubius Instituut TNO (author), Ugele, B. (author), Kempen, J.M. (author), Gebhardt, R. (author), Mijer, P. (author), Burger, H.J. (author), Princen, H.M.G. (author)

Periportal and perivenous hepatocytes were isolated from rat liver by digitonin/collagenase perfusion for investigating the acinar distribution of bile acid synthesis. The specific activity of cholesterol 7 alpha-hydroxylase (EC 1.14.13.17) was 7.9-fold higher in perivenous cells than in periportal hepatocytes. Mass production of bile acids...

article 1991

document

Plasminogen activator, extracellular proteolysis and cancer

Gezondheidsorganisatie TNO Gaubius Instituut TNO (author), Quax, P.H.A. (author)

doctoral thesis 1991

document

Pharmacological modulation of the release of tissue-type plasminogen activator and Von Willebrand factor; a study in the perfused rat hindleg

Gezondheidsorganisatie TNO Gaubius instituut TNO (author), Tranquille-Mouchabeck, N. (author)

doctoral thesis 1991

document

Structure and expression of the human plasminogen activator inhibitor I gene

Gezondheidsorganisatie TNO Gaubius instituut TNO Instituut voor verouderings- en vaatziekten onderzoek TNO (author), Bosma, P.J. (author)

doctoral thesis 1991

document

Diabetes mellitus and fibrinolysis

Gezondheidsorganisatie TNO Gaubius instituut TNO (author), Potter van Loon, B.J (author)

doctoral thesis 1991

document

Cholesterol: geen fabels maar feiten

Gezondheidsorganisatie TNO Gaubius Instituut TNO (author), Gevers Leuven, J.A. (author)

article 1991

document

Use of Mpc-amino acids in solid phase peptide synthesis leads to improved coupling efficiencies

Gezondheidsorganisatie TNO Gaubius Instituut TNO (author), Schielen, W.J.G. (author), Adams, H.P.H.M. (author), Nieuwenhuizen, W. (author), Tesser, G.J. (author)

The Mpc‐group has a somewhat better stability than the Fmoc‐group, resists catalytic hydrogenolysis, is highly stable in acidic media and its elimination product does not polymerize spontaneously. In a direct comparison of coupling efficiencies obtained in solid phase peptide syntheses using Mpc‐ or Fmoc‐amino acids it is shown that the use of...

article 1991

document

The formation, measurement and clinical value of fibrinogen derivatives

Gezondheidsorganisatie TNO Gaubius Instituut TNO (author), Nieuwenhuizen, W. (author)

bookPart 1991

document

Plasma HMW fibrinogen in patients with ischaemic heart disease

Munkvad, S. (author), Nieuwenhuizen, W. (author), Jespersen, J. (author), Gezondheidsorganisatie TNO Gaubius Instituut TNO (author)

article 1990

document

Modulation of the permeability of human endothelial cell monolayers

Gezondheidsorganisatie TNO Gaubius instituut TNO (author), Langeler, E. (author)

doctoral thesis 1990

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Structural requirements of fibrinogen fragments, which enhance the rate of plasminogen activation by t-PA

Gezondheidsorganisatie TNO Gaubius instituut TNO (author), Schielen, W.J.G. (author)

doctoral thesis 1990

document

Genetic heterogeneity in familial dysbetalipoproteinemia; the E2(lys146->gln) variant results in a dominant mode of inheritance

Gezondheidsorganisatie TNO Gaubius Instituut TNO (author), Smit, M. (author), de Knijff, P. (author), van der Kooij-Meijs, C. (author), Groenedijk, C. (author), van den Maagdenberg, A.M.J.M. (author), Gevers Leuven, J.A. (author), Stalenhoef, A.F.H. (author), Stuyt, P.M.J. (author), Frants, R.R. (author), Havekes, L.M. (author)

article 1990

document

Regulation of bile acid synthesis in cultured hepatocytes

Gezondheidsorganisatie TNO Gaubius instituut TNO (author), Kwekkeboom, J. (author)

doctoral thesis 1990

document

Clinical studies on fibrinolytic inhibitors synthesized by the liver

Gezondheidsorganisatie TNO Gaubius instituut TNO (author), Leebeek, F.W.G. (author)

doctoral thesis 1990

document

Influence of apo E polymorphism on the response to simvastatin treatment in patients with heterozygous familial hypercholesterolemia

Gezondheidsorganisatie TNO Gaubius Instituut TNO (author), de Knijff, P. (author), Stalenhoef, A.F.H. (author), Mol, M.J.T.M. (author), Gevers Leuven, J.A. (author), Smit, J. (author), Erkelens, D.W. (author), Schouten, J. (author), Frants, R.R. (author), Havekes, L.M. (author)

In a group of 120 patients with heterozygous familial hypercholesterolemia (FH) the influence of the apolipoprotein E (apoE) polymorphism on pre-treatment plasma lipid levels and on the response to treatment with simvastatin was studied. The apoE phenotype distribution did not differ significantly between the FH group and a sample group of the...

article 1990

document

Receptor-mediated endocytosis of tissue-type plasminogen activator (t-PA) by liver cells

Gezondheidsorganisatie TNO Gaubius Instituut TNO (author), Rijken, D.C. (author), Otter, M. (author), Kuiper, J. (author), van Berkel, T.J.C. (author)

article 1990

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Pharmacokinetics and systemic effects of tissue-type plasminogen activator in normal subjects

Tanswell, P. (author), Seifried, E. (author), Su, P.C.A.F. (author), Feuerer, w. (author), Rijken, D.C. (author), Gezondheidsorganisatie TNO Gaubius instituut TNO (author)

Pharmacokinetics and systemic effects of recombinant tissue-type plasminogen activator (rt-PA) were studied in 18 healthy male volunteers after 30-minute intravenous infusions of placebo, 0.25 mg/kg rt-PA, and 0.5 mg/kg rt-PA. Highly comparable pharmacokinetic parameters were obtained after analysis of rt-PA as both an antigen and an activity....

article 1989