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Diverse effects of the Dutch guidelines for a healthy diet on serum lipids of male patients with type IIA and type IIB hyperlipoproteinemia

Wijsman, B.P. (author), Adrichem, C.M. (author), van 't Hooft, F.M. (author), Gevers Leuven, J.A. (author), van der Laarse, A. (author), Smelt, A.H.M. (author), Gaubius instituut Instituut voor verouderings- en vaatziekten onderzoek TNO (author)

article 1993

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Lipoprotein (a): Relation to other risk factors and genetic heritability; results from a Dutch parent-twin study

Boomsma, D.I. (author), Kaptein, A. (author), Kempen, H.J. (author), Gevers Leuven, J.A. (author), Princen, H.M. (author), Gaubius instituut Instituut voor verouderings- en vaatziekten onderzoek TNO (author)

We measured plasma levels of lipoprotein(a) (Lp(a)) in a sample of 152 Dutch adolescent mono- and dizygotic twin pairs and their parents. The distribution of Lp(a) levels was skewed, with the highest frequencies at low levels and was similar for adult men and women and their children. The relationship of Lp(a) concentrations with other...

article 1993

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Evolutionary conservation of the mouse apolipoprotein e-c1-c2 gene cluster: Structure and genetic variability in inbred mice

Hoffer, M.J.V. (author), Hofker, M.H. (author), van Eck, M.M. (author), Havekes, L.M. (author), Frants, R.R. (author), Gaubius instituut Instituut voor verouderings- en vaatziekten onderzoek TNO (author)

The human apolipoprotein E (APOE), APOC1, pseudo APOC1 (APOC1'), and APOC2 genes are clustered within 48 kb on the long arm of chromosome 19. A mouse Apoe cDNA probe was used to isolate overlapping cosmid clones from a cosmid library of the C57BL/Rij inbred mouse strain. These clones were investigated for the presence of the Apoc1 and Apoc2...

article 1993

document

Eiwitafbraak en tumorcel migratie

Quax, P.H.A. (author), Gaubius instituut Instituut voor verouderings- en vaatziekten onderzoek TNO (author)

article 1993

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Activated protein C accelerates clot lysis by virtue of its coagulant activity

de Fouw, N.J. (author), van Tilburg, N.H. (author), Haverkate, F. (author), Bertina, R.M. (author), Gaubius instituut Instituut voor verouderings- en vaatziekten onderzoek TNO (author)

The effect of human activated protein C (APC) on t-PA dependent fibrinolysis was studied in vitro using plasma (and whole blood) clot lysis techniques. Clot lysis was monitored by measuring the release of soluble 125I-labelled fibrin degradation products from the clot over time. It was demonstrated that the stimulatory effect of APC on plasma...

article 1993

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Lipoproteins in familial dysbetalipoproteinemia; variation of serum cholesterol level associated with VLDL concentration

Zhao, S.P. (author), Smelt, A.H. (author), Gevers Leuven, J.A. (author), van den Maagdenberg, A.M. (author), van der Laarse, A. (author), van 't Hooft, F.N. (author), Gaubius instituut Instituut voor verouderings- en vaatziekten onderzoek TNO (author)

Patients with familial dysbetalipoproteinemia (FD) associated with the apo E2/2 phenotype exhibit a marked interindividual variability in serum cholesterol and triglyceride concentrations. It has been proposed that this variability is due to a combination of the apo E2/2 phenotype and additional genetic factors implicated in diseases like...

article 1993

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High-dose aspirin, thrombin, and coronary angioplasty (letter to the editor)

Andreotti, F. (author), Davies, G.J. (author), Ujang, S.B. (author), Sritara, P. (author), Kluft, C. (author), Maseri, A. (author), Gaubius instituut Instituut voor verouderings- en vaatziekten onderzoek TNO (author)

article 1993

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Influence of acute myocardial infarction and rt-PA therapy on circulating fibrinogen

Seifried, E. (author), Oethinger, M. (author), Tanswell, P. (author), Hoegee-de Nobel, E. (author), Nieuwenhuizen, W. (author), Gaubius instituut Instituut voor verouderings- en vaatziekten onderzoek TNO (author)

In 12 patients treated with 100 mg rt-PA/3 h for acute myocardial infarction (AMI), serial fibrinogen levels were measured with the Clauss clotting rate assay ("functional fibrinogen") and with a new enzyme immunoassay for immunologically intact fibrinogen ("intact fibrinogen"). Levels of functional and "intact fibrinogen" were strikingly...

article 1993

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Perifeer arterieel vaatlijden op jeugdige leeftijd; onderzoek naar de mogelijke oorzaken

Raben, A.M.T.J. (author), Aronson, D.C. (author), van Bockel, J.H. (author), Brommer, E.P.J. (author), Gevers Leuven, J.A. (author), Briet, E. (author), Onkenhout, W. (author), Gaubius instituut Instituut voor verouderings- en vaatziekten onderzoek TNO (author)

article 1993

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Gemfibrozil therapy increases LDL particle size in patients with type IIB hyperlipoproteinaemia

Zhao, S.P. (author), van 't Hooft, F.M. (author), smnelt, a.H.M. (author), Gevers Leuven, J.A. (author), Hollaar, L. (author), van der Laarse, A. (author), Gaubius instituut Instituut voor verouderings- en vaatziekten onderzoek TNO (author)

article 1993

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Reactive coagulation induced by plasmin in patients treated with recombinant tissue-type plasminogen activator

Gram, J. (author), Munkvad, S. (author), Leebeek, F.W.G. (author), Kluft, C. (author), Jespersen, J. (author), Gaubius instituut Instituut voor verouderings- en vaatziekten onderzoek TNO (author)

Background: We and others have demonstrated that administration of thrombolytic agents causes the generation of thrombosis-promoting agents. At present, we have studied whether formation in vivo of excessive amounts of plasmin is responsible for the activation of coagulation in patients treated with recombinant tissue-type plasminogen activator....

article 1993

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Fibrinolytic properties of low and high molecular weight single-chain urokinase-type plasminogen activator

Gaubius instituut Instituut voor verouderings- en vaatziekten onderzoek TNO (author), de Munk, G.A.W. (author)

doctoral thesis 1993

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Characterization of genes involved in the metabolism of atherogenic lipoproteins in the mouse

Gaubius instituut Instituut voor verouderings- en vaatziekten onderzoek TNO (author), Hoffer, M. (author)

doctoral thesis 1993

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Preferential association of apolipoprotein E Leiden with very low density lipoproteins of human plasma

Gaubius instituut Instituut voor verouderings- en vaatziekten onderzoek TNO (author), Fazio, S. (author), Horie, Y. (author), Weisgraber, K.H. (author), Havekes, L.M. (author), Rall Jr., S.C. (author)

Apolipoprotein (apo) E Leiden is a rare variant of human apoE characterized by defective receptor binding and associated with dominant transmission of type III hyperlipoproteinemia. In heterozygotes, apoE Leiden is present in higher concentrations in both total plasma and very low density lipoproteins (VLDL) than the other apoE allele product....

article 1993

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Molecular assembly of plasminogen and tissue-type plasminogen activator on an evolving fibrin surface

Gaubius instituut Instituut voor verouderings- en vaatziekten onderzoek TNO (author), Fleury, V. (author), Loyau, S. (author), Lijnen, H.R. (author), Nieuwenhuizen, W. (author), Anglés-Cano, E. (author)

A well characterized model of an intact and a degraded surface of fibrin that represents the states of fibrin during the initiation and the progression of fibrinolysis was used to quantitatively characterize the molecular interplay between tissue-type plasminogen activator (t-PA), plasminogen and fibrin. The molecular assembly of t-PA and...

article 1993

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The mutation in fibrinogen Bicêtre II (gamma Asn308-->Lys) does not affect the binding of t-PA and plasminogen to fibrin

Gaubius instituut Instituut voor verouderings- en vaatziekten onderzoek TNO (author), Grailhe, P. (author), Boyer-Neumann, C. (author), Haverkate, F. (author), Grimbergen, J. (author), Larrieu, M.J. (author), Anglés-Cano, E. (author)

The aim of this study was to investigate the interactions of t-PA and plasminogen with fibrin derived from an abnormal fibrinogen detected in a 40-year-old male patient who had had an episode of thrombophlebitis with pulmonary embolism. An abnormal fibrinogen was diagnosed on the basis of prolonged thrombin and reptilase times also detected in...

article 1993

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Early cross-linked fibrin in human plasma contains α-polymers with intact fibrinopeptide A

Grøn, B. (author), Filion-Myklebust, C. (author), Benninck, A. (author), Nieuwenhuizen, W. (author), Matsueda, G.R. (author), Brosstad, F. (author), Gaubius instituut Instituut voor verouderings- en vaatziekten onderzoek TNO (author)

alpha-polymer formation, as opposed to gamma-chain dimerization has been considered a relatively late event in factor XIII-induced fibrin stabilization. Recently it has been shown, however, that plasma from healthy individuals and from patients with fibrinaemia contains small amounts of soluble fibrin/fibrinogen oligomers interlinked through...

article 1992

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Effects of exercise training on plasminogen activator inhibitor activity

de Geus, E.J.C. (author), Kluft, C. (author), de Bart, A.C. (author), van Doornen, L.J. (author), Gaubius instituut Instituut voor verouderings- en vaatziekten onderzoek TNO (author)

Plasminogen activator inhibitor (PAI) activity, an important regulator within the fibrinolytic system, has been shown to be a risk indicator for venous and arterial thrombosis. The present study aimed to test the effects of exercise training on PAI activity, and to link possible changes in PAI activity to changes in cardiovascular fitness, body...

article 1992

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Consensus aangaande triglyceriden en 'high density'-lipoproteïne-cholesterol in de Verenigde Staten

Gevers Leuven, J.A. (author), Gaubius instituut Instituut voor verouderings- en vaatziekten onderzoek TNO (author)

Een verhoogd cholesterolgehalte van het bloed is een risicofactor voor vroegtijdige kransslagadervernauwing. De Consensus Cholesterol 1987 en de herziening daarvan in 1991 gaven beleidslijnen voor opsporing, afkappunten, verder onderzoek, interventie et cetera. Dit beleid is goeddeels ook in de rapporten van de Ziekenfondsraad en de...

article 1992

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Grupo de trabajo de Leiden sobre fibrinolysis: procedimientos de recogida y manipulación de sangre para la evaluación del activador del plasminógeno de tipo tisular (t-PA) y del inhibidor-1 del activador del plasminógeno (PAI-1) [Leiden fibrinolysis working party : blood collection and handling procedures for assessment of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1)]

Gaubius instituut Instituut voor verouderings- en vaatziekten onderzoek TNO (author), Kluft, C. (author), Verheijen, J.H. (author)

Procedures of blood collection and handling are different for the various variables in haemostasis and tend to change gradually with progress in knowledge and methods. The Working Party has gathered background information about procedures and discussed minimal requirements specifically for t-PA and PAI-1 assessment. The general procedure from...

article 1992