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Klein Entink, R.H. (author), Fransman, W. (author), Brouwer, D.H. (author)Measurement strategies for exposure to nano-sized particles differ from traditional integrated sampling methods for exposure assessment by the use of real-time instruments. The resulting measurement series is a time series, where typically the sequential measurements are not independent from each other but show a pattern of autocorrelation. This...article 2011
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Agostini, M. (author), Fransman, W. (author), Vocht, F.D. (author), Joode, B.V.W.D. (author), Kromhout, H. (author), TNO Kwaliteit van Leven (author)Objective: To assess dermal exposure to bitumen condensate among road pavers and indoor mastic workers in multiple crews using a semi-quantitative observational method [DeRmal Exposure Assessment Method (DREAM)].Methods: Two skilled observers assessed dermal exposure to bitumen condensate among 85 asphalt workers from 12 crews from nine...article 2011
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Mc Donnell, P.E. (author), Schinkel, J.M. (author), Coggins, M.A. (author), Fransman, W. (author), Kromhout, H. (author), Cherrie, J.W. (author), Tielemans, E.L. (author), TNO Kwaliteit van Leven (author)As it is often difficult to obtain sufficient numbers of measurements to adequately characterise exposure levels, occupational exposure models may be useful tools in the exposure assessment process. This study aims to refine and validate the inhalable dust algorithm of the Advanced REACH Tool (ART) to predict airborne exposure of workers in the...article 2011
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Tielemans, E. (author), Warren, N. (author), Fransman, W. (author), van Tongeren, M. (author), McNally, K. (author), Tischer, M. (author), Ritchie, P. (author), Kromhout, H. (author), Schinkel, J. (author), Schneider, T. (author), Cherrie, J.W. (author), TNO Kwaliteit van Leven (author)This paper provides an outline of the Advanced REACH Tool (ART) version 1.0 and a discussion of how it could be further developed. ART is a higher tier exposure assessment tool that combines mechanistically modelled inhalation exposure predictions with available exposure data using a Bayesian approach. ART assesses exposure for scenarios across...article 2011
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Miller, B.G. (author), Fransman, W. (author), Heederik, D. (author), Hurley, J.F. (author), Kromhout, H. (author), Fitzsimons, E. (author), TNO Kwaliteit van Leven (author)Purpose Published case–control studies of risks of leukaemia following low exposures to benzene in the distribution of petroleum (gasoline) have not all identiWed the same level of risk, but the studies have had diVerences in cohort inclusion, case determination and availability of occupational and lifestyle data. We reviewed the quality and...article 2010
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Vlaanderen, J. (author), Fransman, W. (author), Miller, B. (author), Burstyn, I. (author), Heederik, D. (author), Hurley, F. (author), Vermeulen, R. (author), Kromhout, H. (author), TNO Kwaliteit van Leven (author)Introduction: In occupational epidemiology, differences in the temporal coverage of the exposure history by available exposure measurement data may affect the uncertainty of exposure estimates. In the reporting of results of studies, greater attention should be paid to the extent to which exposure assessments require extrapolation outside the...article 2010
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Schinkel, J. (author), Fransman, W. (author), Heussen, H. (author), Kromhout, H. (author), Marquart, H. (author), Tielemans, E. (author), TNO Kwaliteit van Leven (author)Objectives: For regulatory risk assessment under REACH a tiered approach is proposed in which the first tier models should provide a conservative exposure estimate that can discriminate between scenarios which are of concern and those which are not. The Stoffenmanager is mentioned as a first tier approach in the REACH guidance. In an attempt to...article 2010
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van de Ven, P. (author), Fransman, W. (author), Schinkel, J. (author), Rubingh, C. (author), Warren, N. (author), Tielemans, E. (author), TNO Kwaliteit van Leven (author)The web-based tool "Stoffenmanager" was initially developed to assist small- and medium-sized enterprises in the Netherlands to make qualitative risk assessments and to provide advice on control at the workplace. The tool uses a mechanistic model to arrive at a "Stoffenmanager score" for exposure. In a recent study it was shown that variability...article 2010
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- Spaan, S. (author), Fransman, W. (author), Warren, N. (author), Cotton, R. (author), Cocker, J. (author), Tielemans, E. (author), TNO Kwaliteit van Leven (author), KvL (author) article 2010
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Fransman, W. (author), Schinkel, J. (author), Meijster, T. (author), van Hemmen, J. (author), Tielemans, E. (author), Goede, H. (author), TNO Kwaliteit van Leven (author)Objectives: This paper describes the development and evaluation of an evidence database on the effectiveness of risk management measures (RMMs) to control inhalation exposure. This database is referred to as Exposure Control Efficacy Library (ECEL). Methods: A comprehensive review of scientific journals in the occupational hygiene field was...article 2008
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Tielemans, E. (author), Noy, D. (author), Schinkel, J. (author), Heussen, H. (author), van der Schaaf, D. (author), West, J. (author), Fransman, W. (author), TNO Kwaliteit van Leven (author)In The Netherlands, the web-based tool called 'Stoffenmanager' was initially developed to assist small- and medium-sized enterprises to prioritize and control risks of handling chemical products in their workplaces. The aim of the present study was to explore the accuracy of the Stoffenmanager exposure algorithm. This was done by comparing its...article 2008
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Fransman, W. (author), Roeleveld, N. (author), Peelen, S. (author), de Kort, W. (author), Kromhout, H. (author), Heederik, D. (author), TNO Kwaliteit van Leven (author)BACKGROUND: Nurses and other hospital workers are exposed to antineoplastic drugs during daily activities. Previous studies suggest that antineoplastic drugs at occupational exposure levels may be toxic to reproduction, but these studies are not consistent or conclusive. METHODS: Self-administered questionnaires were completed by 4393 exposed...article 2007
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- Fransman, W. (author), Roeleveld, N. (author), Peelen, S. (author), de Kort, W. (author), Kromhout, H. (author), Heederik, D. (author), TNO Kwaliteit van Leven (author) article 2007
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Meijster, T. (author), Fransman, W. (author), van Hemmen, J. (author), Kromhout, H. (author), Heederik, D. (author), Tielemans, E. (author), TNO Kwaliteit van Leven (author)Objective: The main goal was to investigate the potential of a probabilistic approach for exposure assessment and use this information to evaluate the impact of a complex of policy actions/interventions on dermal exposure to antineoplastic agents among oncology nurses. The central theme of this study was to make optimal use of existing data,...article 2006
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van Wendel de Joode, B. (author), Vermeulen, R. (author), van Hemmen, J.J. (author), Fransman, W. (author), Kromhout, H. (author), TNO Kwaliteit van Leven (author)Background: The authors recently developed a Dermal Exposure Assessment Method (DREAM), an observational semiquantitative method to assess dermal exposures by systematically evaluating exposure determinants using pre-assigned default values. Aim: To explore the accuracy of the DREAM method by comparing its estimates with quantitative dermal...article 2005
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Rajan-Sithamparanadarajah, R. (author), Roff, M. (author), Delgado, P. (author), Eriksson, K. (author), Fransman, W. (author), Gijsbers, J.H.J. (author), Hughson, G. (author), Mäkinen, M. (author), van Hemmen, J.J. (author), TNO Voeding (author)Workplace dermal exposure assessment is a complex task that aims to understand the dynamic interaction between the skin and the hazardous substances present in the surrounding environment. A European project known as RISKOFDERM gathered dermal exposure data in 85 workplaces (industrial and other types) in five countries in Europe. In order to...article 2004
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- Tielemans, E. (author), Heederik, D. (author), Kromhout, H. (author), van Hemmen, J. (author), Meijster, T. (author), Fransman, W. (author), Spaan, S. (author), TNO Voeding (author) article 2004
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Kromhout, H. (author), Fransman, W. (author), Vermeulen, R. (author), Roff, M. (author), van Hemmen, J.J. (author), TNO Voeding (author)Introduction: The RISKOFDERM project collected task-based estimates of potential dermal exposure from a wide range of industries and services from around Europe. A formal statistical analysis was carried out to explore the main components of variability in dermal exposure levels. The central research question was to what extent dermal exposure...article 2004
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TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author), Tielemans, E. (author), Heederik, D. (author), Kromhout, H. (author), van Hemmen, J. (author), Meijster, T. (author), Fransman, W. (author), Spaan, S. (author)Dit artikel beschrijft een benadering om op branche niveau trends in blootstelling aan chemische en biologische agentia te onderzoeken. Hiervoor is de internationale literatuur over blootstellingstrends geïntentariseerd en beschreven. Hierbij is gebleken dat blootstellingsveranderingen in verschillende industrieën zijn onderzocht. Deze zijn...article 2004