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- Krabbendam, T. (author), van den Bogaart, F. (author), Fransman, W. (author), Hoedenmaeker, M. (author), Klaufus, H. (author), Verberk, R. (author), Lombaers, J. (author), Dhondt, S. (author), Wijngaart, M. (author), Albers, R. (author), Miedema, H. (author), Beenker, F. (author), Janssen, E. (author) report 2018
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- Houtman, I.L.D. (author), Fransman, W. (author), Pronk, A. (author), Steenbeek, R. (author) report 2018
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Marquart, H. (author), Franken, R. (author), Goede, H. (author), Fransman, W. (author), Schinkel, J. (author)The ECETOC TRA model (presently version 3.1) is often used to estimate worker inhalation and dermal exposure in regulatory risk assessment. The dermal model in ECETOC TRA has not yet been validated by comparison with independent measured exposure levels. This was the goal of the present study. Measured exposure levels and relevant contextual...article 2017
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Kuijpers, E. (author), Bekker, C. (author), Brouwer, D. (author), le Feber, M. (author), Fransman, W. (author)Exposure assessment for nano-objects, and their aggregates and agglomerates (NOAA), has evolved from explorative research toward more comprehensive exposure assessment, providing data to further develop currently used conservative control banding (CB) tools for risk assessment. This study aims to provide an overview of current knowledge on...article 2017
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- Manders, M. (author), van den Bogaart, F. (author), Dhondt, S. (author), Pelders, R. (author), Fransman, W. (author), de Vos, S. (author), Miedema, H. (author), Werij, H. (author), Verberk, R. (author), Lombaers, J. (author), Vink, H.J. (author), Janssen, E. (author), de Vlieger, J. (author) report 2017
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Bekker, C. (author), Fransman, W. (author), Boessen, R. (author), Oerlemans, A. (author), Ottenbros, I.B. (author), Vermeulen, R. (author)Background: Nano-specific inhalation exposure models could potentially be effective tools to assess and control worker exposure to nano-objects, and their aggregates and agglomerates (NOAA). However, due to the lack of reliable and consistent collected NOAA exposure data, the scientific basis for validation of the existing NOAA exposure models...article 2017
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Fransman, W. (author), Pronk, A. (author), Schelvis, R.M.C. (author), Moons, A.M.M. (author)Although work is good for you, it can actually be bad for your health, too. Poor working conditions are responsible for 5% of the total disease burden1, a percentage that is the same as the figure for the adverse health effects resulting from an unhealthy environment or obesity. After smoking, these three factors are responsible for the major...other 2017
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Schaddelee-Scholten, B. (author), Schuilenborg, L. (author), Fransman, W. (author), Spaan, S. (author), Weyers, M.M. (author)In de daarin geselecteerde branches Metaal, Chemie en Bouw zijn in het tweede tertaal bedrijfsbezoeken uitgevoerd, gekoppeld aan interviews met werkgevers en werknemers. Ook andere belangrijke stakeholders zijn geïnterviewd. Onderwerpen die aan de orde kwamen zijn o.a. de organisatie van de bedrijfsgezondheidszorg, de bedrijfscultuur met...report 2017
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Fransman, W. (author), Pronk, A. (author), Schelvis, R.M.C. (author), Moons, A.M.M. (author)In Nederland overlijden jaarlijks zo’n 4.100 mensen aan beroepsziekten, waarvan ongeveer 2.700 aan werkgerelateerde kanker. Ondanks goede initiatieven in risicovolle sectoren als de bouw, metaal en de houtverwerkende industrie om een gezonde werksituatie te creëren, blijkt de blootstelling aan kankerverwekkende stoffen als respirabel kwarts,...other 2017
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Brouwer, D. (author), Boessen, R. (author), van Duuren-Stuurman, B. (author), Bard, D. (author), Moehlmann, C. (author), Bekker, C. (author), Fransman, W. (author), Entink, R.K. (author)Tiered or stepwise approaches to assess occupational exposure to nano-objects, and their agglomerates and aggregates have been proposed, which require decision rules (DRs) to move to a next tier, or terminate the assessment. In a desk study the performance of a number of DRs based on the evaluation of results from direct reading instruments was...article 2016
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Fransman, W. (author), Bekker, C. (author), Tromp, P. (author), Duis, W.B. (author)Increasing production and applications of manufactured nano objects (MNOs) have become a source for human exposure and therefore raise concerns and questions about the possible health effects. In this study, the potential release of nano objects, their agglomerates, and aggregates (NOAA) as a result of sanding of hardwood treated with MNOs...article 2016
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van Harmelen, T. (author), Zondervan-van den Beuken, E.K. (author), Brouwer, D.H. (author), Kuijpers, E. (author), Fransman, W. (author), Buist, H.B. (author), Ligthart, T.N. (author), Hincapié, I. (author), Hischier, R. (author), Linkov, I. (author), Nowack, B. (author), Studer, J. (author), Hilty, L. (author), Som, C. (author)The fast penetration of nanoproducts on the market under conditions of significant uncertainty of their environmental properties and risks to humans creates a need for companies to assess sustainability of their products. Evaluation of the potential benefits and risks to build a coherent story for communication with clients, authorities,...article 2016
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Bekker, C. (author), Voogd, E. (author), Fransman, W. (author), Vermeulen, R. (author)Background: Control banding can be used as a first-tier assessment to control worker exposure to nano-objects and their aggregates and agglomerates (NOAA). In a second tier, more advanced modelling approaches are needed to produce quantitative exposure estimates. As currently no general quantitative nano-specific exposure models are available,...article 2016
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Oksel, C. (author), Subramanian, V. (author), Semenzin, E. (author), Ma, C.Y. (author), Hristozov, D. (author), Wang, X.Z. (author), Hunt, N. (author), Costa, A. (author), Fransman, W. (author), Marcomini, A. (author), Wilkins, T. (author)While the risk management of engineered nanomaterials (ENMs) receives significant attention, there is still a limited understanding of how to select optimal risk management measures (RMMs) for controlling and mitigating the risks associated with exposure to ENMs. Clearly, there exists a need to expand current risk management practices to ensure...article 2016
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- Don, B. (author), van den Bogaart, F. (author), Dhondt, S. (author), Pelders, R. (author), Fransman, W. (author), de Vos, S. (author), Miedema, H. (author), Snijders, B. (author), Verberk, R. (author), Lombaers, J. (author), Beenker, F. (author), Janssen, E. (author), de Vlieger, J. (author) report 2016
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- Bekker, C. (author), Kuijpers, E. (author), Brouwer, D.H. (author), Vermeulen, R. (author), Fransman, W. (author) article 2015
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Koivisto, A.J. (author), Aromaa, M. (author), Koponen, I.K. (author), Fransman, W. (author), Jensen, K.A. (author), Mäkelä, J.M. (author), Hämeri, K.J. (author)Nanoparticle (particles with diameter ≤100 nm) exposure is recognized as a potentially harmful size fraction for pulmonary particle exposure. During nanoparticle synthesis, the number concentrations in the process room may exceed 10 × 106 cm−3. During such conditions, it is essential that the occupants in the room wear highly reliable high...article 2015
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Jiménez, A.S. (author), Rashid, S. (author), Brouwer, D. (author), Fransman, W. (author), Fito, C. (author), Boulougouris, G. (author), van Tongeren, M. (author)The development of nanotechnology has reached a point where it is being widely applied, and numerous nanomaterials and nano-enabled products are handled across a broad range of industrial sectors. Exposure extends beyond occupational settings as products containing nanomaterials are used by different consumer groups. Despite the knowledge on...conference paper 2015
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Walser, T. (author), Meyer, D. (author), Fransman, W. (author), Buist, H. (author), Kuijpers, E. (author), Brouwer, D. (author)Life-Cycle Assessment (LCA) is a well-established method to evaluate impacts of chemicals on the environment and human health along the lifespan of products. However, the increasingly produced and applied nanomaterials (defined as one dimensionarticle 2015
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Schinkel, J. (author), Fransman, W. (author), McDonnell, P.E. (author), Entink, R.K. (author), Tielemans, E. (author), Kromhout, H. (author)Objectives: The aim of this study was to assess the reliability of the Advanced REACH Tool (ART) by (i) studying interassessor agreement of the resulting exposure estimates generated by the ART mechanistic model, (ii) studying interassessor agreement per model parameters of the ART mechanistic model, (iii) investigating assessor characteristics...article 2014