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Fransman, W. (author), Otten, W. (author), Marquart, H. (author), Preuhs, K. (author), Willemsen, J. (author), Boumann, H. (author), Gerritsen, R. (author)Objectives: Within the chemical legislation, REACH was implemented in order to improve safe working conditions with hazardous substances. Literature and real-life experiences by those concerned have shown that there are still gaps with a need for improved risk communication. This study elaborated on how information provided by REACH is...article 2023
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Fransman, W. (author), Arnone, M. (author), Borghi, F. (author), Cattaneo, A. (author), Cavallo, D.M. (author), Cherrie, J.W. (author), Franken, R. (author), Galea, K.S. (author), van der Haar, R. (author), Heussen, G.A.H. (author), Jensen, K.A. (author), Koponen, M. (author), Koppisch, D. (author), Kromhout, H. (author), Luo, KY.S. (author), McNally, K. (author), Säämänen, A. (author), Spinazzè, A. (author), van Tongeren, M. (author), Jeroen, (author), Vanoirbeek, J. (author), Verpaele, S. (author), Vetter, D. (author), Viegas, S. (author), Warren, N. (author)In this article, we have responded to the key statements in the article by Koivisto et al. (2022) that were incorrect and considered to be a biased critique on a subset of the exposure models used in Europe (i.e. ART and Stoffenmanager®) used for regulatory exposure assessment. We welcome scientific discussions on exposure modelling (as was done...article 2022
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Schlüter, U. (author), Arnold, S. (author), Borghi, F. (author), Cherrie, J. (author), Fransman, W. (author), Heussen, H. (author), Jayjock, M. (author), Jensen, K.A. (author), Koivisto, J. (author), Koppisch, D. (author), Meyer, J. (author), Spinazzè, A. (author), Tanarro, C. (author), Verpaele, S. (author), von Goetz, N. (author)On 20 October 2020, the Working Group “Exposure Models” of the Europe Regional Chapter of the International Society of Exposure Science (ISES Europe) organised an online workshop to discuss the theoretical background of models for the assessment of occupational exposure to chemicals. In this report, participants of the workshop with an active...article 2022
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Kroese, E.D. (author), Fransman, W. (author), Dekkers, S. (author)Op Europees niveau worden stoffen die C, M of R zijn door het agentschap ECHA1 op een autorisatielijst gezet met als doel ze op termijn te verbieden en wordt tot dat moment gebruik van de stof slechts beperkt toegestaan en/of enkel verleend op uitdrukkelijke verzoek voor specifieke toepassingen. In Nederland moeten bedrijven volgens het...report 2022
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van den Bossche, S. (author), Dhondt, S. (author), Fransman, W. (author)The world of work is changing at an ever-increasing rate. Digitalisation, with the COVID-19 pandemic as a catalyst, climate change and demographic developments are causing shifts in the labour market. Some jobs are changing, others are disappearing and new jobs are taking their place. These changes offer opportunities, but are at the same time...other 2022
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Schlüter, U. (author), Meyer, J. (author), Ahrens, A. (author), Borghi, F. (author), Clerc, F. (author), Delmaar, C. (author), Di Guardo, A. (author), Dudzina, T. (author), Fantke, P. (author), Fransman, W. (author), Hahn, S. (author), Heussen, H. (author), Jung, C. (author), Koivisto, J. (author), Koppisch, D. (author), Paini, A. (author), Savic, N. (author), Spinazzè, A. (author), Jeddi, M.Z. (author), von Goetz, N. (author)Exposure models are essential in almost all relevant contexts for exposure science. To address the numerous challenges and gaps that exist, exposure modelling is one of the priority areas of the European Exposure Science Strategy developed by the European Chapter of the International Society of Exposure Science (ISES Europe). A strategy was...article 2022
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in der Maur, M. (author), Kuijpers, E. (author), Fransman, W. (author), van der Wal-Bellaart, M. (author)Gezond en veilig werken begint bij de Risico Inventarisatie en Evaluatie (RI&E) inclusief een plan van aanpak (PVA). De RI&E is de kurk waar het arbobeleid op drijft. Een kwalitatief goede RI&E helpt bij het creëren van een goede, veilige en gezonde werkomgeving voor werknemers. Elk jaar overlijden circa 4100 mensen door beroepsziekten, waarvan...report 2022
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Otten, W. (author), Marquart, H. (author), Preuhs, K. (author), Willemsen, J. (author), Boumann, H. (author), Gerritsen, R. (author), Fransman, W. (author)Presently, there is a lack of knowledge on the effectiveness of the information exchange on safe use conditions up and down the supply chain. The aim of the present research project CEFIC LRI B23 was to provide a substantial contribution to the knowledge needed to optimize information exchange on safe use conditions, specifically under REACH....report 2022
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Janssen, A. (author), Fransman, W. (author)Verslag bijeenkomst Contactgroep Gezondheid en Chemie (CGC) in samenwerking met de Nederlandse Vereniging voor Arbeidshygiëne (NVvA) 25 november 2021.article 2022
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Krystek, P. (author), Shandilya, N. (author), Fransman, W. (author)Driven by the concept of the ‘four generations of nanomaterials’, the current state of the knowledge on risk assessment of future generation is explored for active nanomaterials. Through case studies, we identify challenges and evaluate the preparedness of characterization methods, available risk assessment modeling tools, and analytical...article 2021
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Goede, H. (author), Kuijpers, E. (author), Krone, T. (author), le Feber, M. (author), Franken, R. (author), Fransman, W. (author), Duyzer, J. (author), Pronk, A. (author)This commentary explores the use of high-resolution data from new, miniature sensors to enrich models that predict exposures to chemical substances in the workplace. To optimally apply these sensors, one can expect an increased need for new models that will facilitate the interpretation and extrapolation of the acquired time-resolved data. We...article 2021
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Janssen, A. (author), Fransman, W. (author)Inarticle 2021
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Kuijpers, E. (author), van Wel, L. (author), Loh, M. (author), Galea, K.S. (author), Makris, K.C. (author), Stierum, R. (author), Fransman, W. (author), Pronk, A. (author)Introduction: Oil and gas workers have been shown to be at increased risk of chronic diseases including cancer, asthma, chronic obstructive pulmonary disease, and hearing loss, among others. Technological advances may be used to assess the external (e.g. personal sensors, smartphone apps and online platforms, exposure models) and internal...article 2021
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Nymark, P. (author), Bakker, M. (author), Dekkers, S. (author), Franken, R. (author), Fransman, W. (author), García-Bilbao, A. (author), Greco, D. (author), Gulumian, M. (author), Hadrup, N. (author), Halappanavar, S. (author), Hongisto, V. (author), Hougaard, K. (author), Jensen, K. (author), Kohonen, P. (author), Koivisto, A.J. (author), Dal Maso, M. (author), Oosterwijk, T. (author), Poikkimäki, M. (author), Rodriguez-Llopis, I. (author), Stierum, R. (author), Sørli, J.B. (author), Grafström, R. (author)Advanced material development, including at the nanoscale, comprises costly and complex challenges coupled to ensuring human and environmental safety. Governmental agencies regulating safety have announced interest toward acceptance of safety data generated under the collective term New Approach Methodologies (NAMs), as such technologies...article 2020
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Shandilya, N. (author), Marcoulaki, E. (author), Barruetabeña, L. (author), Rodríguez Llopis, I. (author), Noorlander, C. (author), Sánchez Jiménez, A. (author), Oudart, Y. (author), Puelles, R.C. (author), Pérez-Fernández, M. (author), Falk, A. (author), Resch, S. (author), Sips, A. (author), Fransman, W. (author)The challenge in ensuring the safety of manufactured nanomaterials and products stems from the lack of knowledge among industries about the potential environment and health risks of nanotechnology based innovations and the legislations that apply to them. A lack of information and preparedness for the regulatory safety assessment of innovative...article 2020
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Franken, R. (author), Heringa, M.B. (author), Oosterwijk, T. (author), dal Maso, M. (author), Fransman, W. (author), Kanerva, T. (author), Liguori, B. (author), Poikkimäki, M. (author), Rodriguez-Llopis, I. (author), Säämänen, A. (author), Stockmann-Juvala, H. (author), Suarez-Merino, B. (author), alstrup Jensen, K. (author), Stierum, R. (author)The current work describes the interaction with various stakeholder groups to establish consensus on stage-gate specific criteria that human risk assessment (HRA) models for manufactured nanomaterials (MN) need to comply with. During the decisive steps in the innovation process, which can be described in a simplified way as stage-gates, it is...article 2020
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Franken, R.A. (author), Kasiotis, K.M. (author), Tsakirakis, A.N. (author), Chartzela, I. (author), Anastasiadou, P. (author), Fransman, W. (author), Gerritsen-Ebben, R.M. (author), Spaan, S. (author), Goede, H. (author), Machera, K. (author), Gerritsen-Ebben, R. (author)For many work situations only insufficient exposure data are available to perform proper risk assessment. Because measuring worker exposure can be time consuming and resource intense, the availability of reliable exposure models is important when performing risk assessments. However, the development and improvement of exposure models are...article 2020
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Cherrie, J.W. (author), Fransman, W. (author), Heussen, G.A.H. (author), Koppisch, D. (author), Jensen, K.A. (author)Model tools for estimating hazardous substance exposure are an accepted part of regulatory risk assessments in Europe, and models underpin control banding tools used to help manage chemicals in workplaces. Of necessity the models are simplified abstractions of real-life working situations that aim to capture the essence of the scenario to give...article 2020
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Shandilya, N. (author), Marcoulaki, E. (author), Vercauteren, S. (author), Witters, H. (author), Johansson, E. (author), Salazar-Sandoval, E.J. (author), Viitanen, A.K. (author), Bressot, C. (author), Fransman, W. (author)This work presents a blueprint or set of guidelines for the planning and development of sustainable national centers dealing with the safety of nanomaterials and nanotechnologies toward public health and environment. The blueprint was developed following a methodological approach of EU-wide online survey and workshop with several stakeholders....article 2020
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Franken, R. (author), Shandilya, N. (author), Marquart, H. (author), McNally, K. (author), Fransman, W. (author)Measured data are generally preferred to modelled estimates of exposure. Grouping and read-across is already widely used and accepted approach in toxicology, but an appropriate approach and guidance on how to use existing exposure measurement data on one substance and work situation for another substance and/or work situation is currently not...article 2020