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Najjar, A. (author), Punt, A. (author), Wambaugh, J. (author), Paini, A. (author), Ellison, C. (author), Fragki, S. (author), Bianchi, E. (author), Zhang, F. (author), Westerhout, J. (author), Mueller, D. (author), Li, H. (author), Shi, Q. (author), Gant, T.W. (author), Botham, P. (author), Bars, R. (author), Piersma, A. (author), van Ravenzwaay, B. (author), Kramer, N.I. (author)With an increasing need to incorporate new approach methodologies (NAMs) in chemical risk assessment and the concomitant need to phase out animal testing, the interpretation of in vitro assay readouts for quantitative hazard characterisation becomes more important. Physiologically based kinetic (PBK) models, which simulate the fate of chemicals...article 2022
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Fragki, S. (author), Piersma, A.H. (author), Westerhout, J. (author), Kienhuis, A. (author), Kramer, N.I. (author), Zeilmaker, M.J. (author)Toxicology is moving away from animal testing towards in vitro tools to assess chemical safety. This new testing framework requires a quantitative method, i.e. kinetic modelling, which extrapolates effective concentrations in vitro to a bioequivalent human dose in vivo and which can be applied on “high throughput screening” of a wide variety of...article 2022