A novel model based approach of an integrated ventilation and heating model for monitoring and control

Control of HVAC systems may reduce congestion of the electricity grid on district level by shifting energy demand of buildings and increase the self-consumption of local photovoltaic energy. To achieve an optimal control of ventilation, occupant behaviour should be taken into account. To describe occupant behaviour, usually black box models are...

Reducing peak load of renewable energy at district level with predictive twins

One of the major challenges in the energy transition of the built environment is how to integrate energy-producing neighbourhoods into the existing energy infrastructure. The aim is to avoid the peak load of local renewable energy by consuming it at district level as much as possible. The energy transition puts an increasing burden on the local...

Reducing peak load of renewable energy at district level with predictive twins

One of the major challenges in the energy transition of the built environment is how to integrate energy-producing neighbourhoods into the existing energy infrastructure. The aim is to avoid the peak load of local renewable energy by consuming it at district level as much as possible. The energy transition puts an increasing burden on the local...

Space heating demand profiles of districts considering temporal dispersion of thermostat settings in individual buildings

Future energy infrastructures are expected to be smart, with the application of energy storage and demand-side management strategies. To size the energy storage and assess the flexibility of the heat demand in a district, insight into its heat demand profile is a prerequisite. A tool was developed to generate the hourly space heating demand of a...

A kinetic model predicts SpCas9 activity, improves off-target classification, and reveals the physical basis of targeting fidelity

The S. pyogenes (Sp) Cas9 endonuclease is an important gene-editing tool. SpCas9 is directed to target sites based on complementarity to a complexed single-guide RNA (sgRNA). However, SpCas9-sgRNA also binds and cleaves genomic off-targets with only partial complementarity. To date, we lack the ability to predict cleavage and binding activity...