Searched for: author:"Escher, S.E."
(1 - 7 of 7)
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Rovida, C. (author), Escher, S.E. (author), Herzler, M. (author), Bennekou, S.H. (author), Kamp, H. (author), Kroese, D.E. (author), Maslankiewicz, L. (author), Moné, M.J. (author), Patlewicz, G. (author), Sipes, N. (author), van Aerts, L. (author), White, A. (author), Yamada, T. (author), van de Water, B. (author)
The use of new approach methodologies (NAMs) in support of read-across (RAx) approaches for regulatory purposes is a main goal of the EU-ToxRisk project. To bring this forward, EU-ToxRisk partners convened a workshop in close collaboration with regulatory representatives from key organizations including European regulatory agencies, such as the...
article 2021
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Moné, M.J. (author), Pallocca, G. (author), Escher, S.E. (author), Exner, T. (author), Herzler, M. (author), Hougaard Bennekou, S. (author), Kamp, H. (author), Kroese, E.D. (author), Leist, M. (author), Steger-Hartmann, T. (author), van de Water, B. (author)
In 2016, the European Commission launched the EU-ToxRisk research project to develop and promote animal-free approaches in toxicology. The 36 partners of this consortium used in vitro and in silico methods in the context of case studies (CSs). These CSs included both compounds with a highly defined target (e.g. mitochondrial respiratory chain...
article 2020
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Escher, S.E. (author), Kamp, H. (author), Bennekou, S.H. (author), Bitsch, A. (author), Fisher, C. (author), Graepel, R. (author), Hengstler, J.G. (author), Herzler, M. (author), Knight, D. (author), Leist, M. (author), Norinder, U. (author), Ouédraogo, G. (author), Pastor, M. (author), Stuard, S. (author), White, A. (author), Zdrazil, B. (author), van de Water, B. (author), Kroese, D. (author)
Read-across is one of the most frequently used alternative tools for hazard assessment, in particular for complex endpoints such as repeated dose or developmental and reproductive toxicity. Read-across extrapolates the outcome of a specific toxicological in vivo endpoint from tested (source) compounds to “similar” (target) compound(s). If...
article 2019
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Graepel, R. (author), ter Braak, B. (author), Escher, S.E. (author), Fisher, C. (author), Gardner, I. (author), Kamp, H. (author), Kroese, D. (author), Leist, M. (author), Moné, M.J. (author), Pastor, M. (author), van de Water, B. (author)
The EU-ToxRisk research project is an interdisciplinary research project that aims to advance the paradigm shift in toxicology towards new approach methodology (NAM)–based approaches for risk assessment. In this European research project, experts in the fields of in vitro and in silico techniques and risk assessment from academia, industry and...
article 2019
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Tluczkiewicz, I. (author), Batke, M. (author), Kroese, D. (author), Buist, H. (author), Aldenberg, T. (author), Pauné, E. (author), Grimm, H. (author), Kühne, R. (author), Schüürmann, G. (author), Mangelsdorf, I. (author), Escher, S.E. (author), TNO Kwaliteit van Leven (author), KvL (author)
In the FP6 European project OSIRIS, Integrated Testing Strategies (ITSs) for relevant toxicological endpoints were developed to avoid new animal testing and thus to reduce time and costs. The present paper describes the development of an ITS for repeated-dose toxicity called RepDose ITS which evaluates the conditions under which in vivo non...
article 2013
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Tluczkiewicz, I. (author), Buist, H.E. (author), Martin, M.T. (author), Mangelsdorf, I. (author), Escher, S.E. (author)
The present report describes a strategy to refine the current Cramer classification of the TTC concept using a broad database (DB) termed TTC RepDose. Cramer classes 1-3 overlap to some extent, indicating a need for a better separation of structural classes likely to be toxic, moderately toxic or of low toxicity.Groups of structurally similar...
article 2011
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Escher, S.E. (author), Tluczkiewicz, I. (author), Batke, M. (author), Bitsch, A. (author), Melber, C. (author), Kroese, E.D. (author), Buist, H.E. (author), Mangelsdorf, I. (author), TNO Kwaliteit van Leven (author)
The thresholds of toxicological concern (TTCs) define limit values for substances of unknown toxicity below which dietary intake is considered to be of no concern to human health. The TTC concept has already been used for risk assessment of e.g. food contaminants or flavoring substances and is in discussion to be applied to other classes of...
article 2010
Searched for: author:"Escher, S.E."
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