Searched for: author:"Centraal Instituut voor Voedingsonderzoek TNO "
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TNO Kwaliteit van Leven Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)
ln 2018 komt er een einde aan de aanwezigheid van TNO aan de Utrechtseweg 48 in Zeist. Duizenden TNO'ers (en bezoekers) zijn gedurende vele jaren het markante gebouw met de nog markantere trap binnengekomen en hebben gedurende die jaren daar hun beste krachten gegeven. Wanneer het gebouw kon spreken, dan zouden we wellicht versteld staan wat er...
book 2017
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Loman, S. (author), van der Kamp, J.W. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Background: Current dietary and public health recommendations addressing obesity do not as yet include recommendations pertaining to the gut microbiome. As a corollary, no microbiome-related health claims made on foods have as yet been proposed. Scope: The MyNewGut project aims, amongst others, to provide guidance for the establishment of...
article 2016
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Moerman, F. (author), Kastelein, J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
To satisfy consumer demand for "fresh-like" additive-free foods, many food producers nowadays apply mild processing and conservation techniques that often shorten the shelf-life of food, may put food at risk and may compromise consumer health. However, food legislation developed in many countries around the globe requires that microbiologically...
bookPart 2014
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Chen, Y. (author), Sun, A. (author), Wang, M. (author), Zhu, Z. (author), Ouwerkerk, P.B.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Glutelins are the most abundant storage proteins in rice grain and can make up to 80 % of total protein content. The promoter region of GluB-1, one of the glutelin genes in rice, has been intensively used as a model to understand regulation of seed-storage protein accumulation. In this study, we describe a zinc finger gene of the Cys3His1 (CCCH...
article 2014
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Martin, A.H. (author), Baigts Allende, D. (author), Munialo, C.D. (author), Urbonaite, V. (author), Pouvreau, L. (author), de Jongh, H.H.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The exploration of microstructures and textures of protein based systems is essential to understand (oral) breakdown properties and thereby textural aspects, or macroscopic functionalities such as water holding. Upon structure breakdown, the applied energy (W) is primarily directed towards fracture (Wf) for particulate gels. For stranded gels...
conference paper 2013
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van Eunen, K. (author), Rossell, S. (author), Bouwman, J. (author), Westerhoff, H.V. (author), Bakker, B.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Regulation analysis is a methodology that quantifies to what extent a change in the flux through a metabolic pathway is regulated by either gene expression or metabolism. Two extensions to regulation analysis were developed over the past years: (i) the regulation of Vmax can be dissected into the various levels of the gene-expression cascade,...
conference paper 2011
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Monachese, M. (author), Cunningham-Rundles, S. (author), Diaz, M.A. (author), Guerrant, R. (author), Hummelen, R. (author), Kemperman, R. (author), Kerac, M. (author), Kort, R. (author), Merenstein, D. (author), Panigrahi, P. (author), Ramakrishna, B. (author), Safdar, N. (author), Shane, A. (author), Trois, L. (author), Reid, G. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Infectious disease in the developing world continues to represent one of the greatest challenges facing humanity. Every year over a million children suffer and die from the sequela of enteric infections, and in 2008 was estimated almost 2.7 million (UNAIDS 2009 update) adults and children became infected with human immunodeficiency virus (HIV)....
article 2011
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Rubio-Aliaga, I. (author), de Roos, B. (author), Duthie, S.J. (author), Crosley, L.K. (author), Mayer, C. (author), Horgan, G. (author), Colquhoun, I.J. (author), Le Gall, G. (author), Huber, F. (author), Kremer, W. (author), Rychlik, M. (author), Wopereis, S. (author), van Ommen, B. (author), Schmidt, G. (author), Heim, C. (author), Bouwman, F.G. (author), Mariman, E.C. (author), Mulholland, F. (author), Johnson, I.T. (author), Polley, A.C. (author), Elliott, R.M. (author), Daniel, H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Fasting is one of the simplest metabolic challenges that can be performed in humans. We here report for the first time a comprehensive analysis of the human "fasting metabolome" obtained from analysis of plasma and urine samples in a small cohort of healthy volunteers, using nuclear magnetic resonance (NMR), gas chromatography- and liquid...
article 2011
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Bildt, M.M. (author), Snoek-van Beurden, A.M.P. (author), de Groot, J. (author), van El, B. (author), Kuijpers-Jagtman, A.M. (author), van den Hoff, J.W. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Background and Objective: The purpose of this study was to investigate the effects of chemically modified tetracyclines (CMTs) on the production of gelatinases [matrix metalloproteinase (MMP)-2 and -9] by human periodontal ligament (PDL) cells, and on the activity of recombinant gelatinases. Material and Methods: Human PDL cells were cultured...
article 2006
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Schouten, L.J. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
Although obesity is an established risk factor for endometrial cancer, evidence linking risk to height, weight change since age 20, and physical activity is limited. In this case-cohort study, 62 573 women from The Netherlands Cohort Study on Diet and Cancer were followed up from 1986 to 1995, and 226 endometrial cancer case patients were...
article 2004
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Fox, T.E. (author), van den Heuvel, E.G.H.M. (author), Atherton, C.A. (author), Dainty, J.R. (author), Lewis, D.J. (author), Langford, N.J. (author), Crews, H.M. (author), Luten, J.B. (author), Lorentzen, M. (author), Sieling, F.W. (author), van Aken-Schneyder, P. (author), Hoek, M. (author), Kotterman, M.J.J. (author), van Dael, P. (author), Firweather-Tail, S.J. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
Objective: To measure the bioavailability of selenium from cooked and raw fish in humans by estimating and comparing apparent absorption and retention of selenium in biosynthetically labelled fish with labelled selenate and biosynthetically labelled selenium in brewers yeast. Design: The intervention study was a parallel, randomised, reference...
article 2004
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Kralj, S. (author), van Geel-Schutten, G.H. (author), van der Maarel, M.J.E.C. (author), Dijkhuizen, L. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
Lactobacillus reuteri strain 121 uses sucrose for synthesis of a unique, soluble glucan ('reuteran') with mainly α-(1→4) glucosidic linkages. The gene (gtfA) encoding this glucansucrase enzyme had previously been characterized. Here, a detailed biochemical and molecular analysis of the GTFA enzyme is presented. This is believed to be the first...
article 2004
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ter Bogt, N.C.W. (author), Hoekstra, T. (author), Roest, M. (author), van de Vijver, L.P.L. (author), Verhoef, P. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
article 2004
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Waalkens-Berendsen, D.H. (author), Kuilman-Wahls, M.E.M. (author), Bär, A. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
The embryotoxicity/teratogenicity of neohesperidin dihydrochalcone (NHDC) was examined in Wistar Crl:(WI)WU BR rats. NHDC was fed at dietary concentrations of 0, 1.25, 2.5 or 5 to groups of 28 mated female rats from day 0 to 21 of gestation. At Cesarean section 25, 22, 23, and 23 rats were found to be pregnant in the control, low-, mid-, and...
article 2004
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Kralj, S. (author), van Geel-Schutten, G.H. (author), Dondorff, M.M.G. (author), Kirsanovs, S. (author), van der Maarel, M.J.E.C. (author), Dijkhuizen, L. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
Members of the genera Streptococcus and Leuconostoc synthesize various α-glucans (dextran, alternan and mutan). In Lactobacillus, until now, the only glucosyltransferase (GTF) enzyme that has been characterized is gtfA of Lactobacillus reuteri 121, the first GTF enzyme synthesizing a glucan (reuteran) that contains mainly α-(1 → 4) linkages...
article 2004
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Brink, E.J. (author), Boelsma, E. (author), Steijns, J. (author), Hendriks, H.F.J. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
The aim of the study was to investigate the bioavailability of tryptophan (Trp) from a Trp-enriched peptide mixture in healthy men. A second objective was to investigate the effect of this Trp-enriched protein hydrolysate on potential parameters of serotonergic activity. serum serotonim melatonin and prolactin and urinary 5-hydroxyindol-acetic...
article 2004
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Snopov, S.A. (author), de Gruijl, F.R. (author), Roza, L. (author), van der Leun, J.C. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
Studies of UV-induced skin cancers show that malignisation of skin cells, as well as alterations in anti-tumor immune control, are triggered by UV-induced lesions in cellular DNA. Such lesions can probably appear in the human mononuclear leukocytes (lymphocytes) during exposure of skin to sunlight. With the aim of studying the processing of UV...
article 2004
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Cho, E. (author), Smith-Warner, S.A. (author), Spiegelman, D. (author), Beeson, W.L. (author), van den Brandt, P.A. (author), Colditz, G.A. (author), Folsom, A.R. (author), Fraser, G.E. (author), Freudenheim, J.L. (author), Giovannucci, E. (author), Goldbohm, R.A. (author), Graham, S. (author), Miller, A.B. (author), Pietinen, P. (author), Potter, J.D. (author), Rohan, T.E. (author), Terry, P. (author), Toniolo, P. (author), Virtanen, M.J. (author), Willet, W.C. (author), Wolk, A. (author), Wu, K. (author), Yaun, S.-S. (author), Zeleniuch-Jacquotte, A. (author), Hunter, D.J. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
Background: Studies in animals have suggested that calcium may reduce the risk of colorectal cancer. However, results from epidemiologic studies of intake of calcium or dairy foods and colorectal cancer risk have been inconclusive. Methods: We pooled the primary data from 10 cohort studies in five countries that assessed usual dietary intake by...
article 2004
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Männistö, S. (author), Smith-Warner, S.A. (author), Spiegelman, D. (author), Albanes, D. (author), Anderson, K. (author), van den Brandt, P.A. (author), Cerhan, J.R. (author), Colditz, G. (author), Feskanich, D. (author), Freudenheim, J.L. (author), Giovannucci, E. (author), Goldbohm, R.A. (author), Graham, S. (author), Miller, A.B. (author), Rohan, T.E. (author), Virtamo, J. (author), Willett, W.C. (author), Hunter, D.J. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
Intervention trials with supplemental β-carotene have observed either no effect or a harmful effect on lung cancer risk. Because food composition databases for specific carotenoids have only become available recently, epidemiological evidence relating usual dietary levels of these carotenoids with lung cancer risk is limited. We analyzed the...
article 2004
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Tielemans, E. (author), Heederik, D. (author), Kromhout, H. (author), van Hemmen, J. (author), Meijster, T. (author), Fransman, W. (author), Spaan, S. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
Dit artikel beschrijft een benadering om op branche niveau trends in blootstelling aan chemische en biologische agentia te onderzoeken. Hiervoor is de internationale literatuur over blootstellingstrends geïntentariseerd en beschreven. Hierbij is gebleken dat blootstellingsveranderingen in verschillende industrieën zijn onderzocht. Deze zijn...
article 2004
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