Searched for: author%3A%22Busker%2C+R.W.%22
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Berghuis, N.F. (author), Mars-Groenendijk, R.H. (author), Busker, R.W. (author), Paauw, A. (author), van Leeuwen, H.C. (author)
CRISPR–Cas (CC)-based detection technologies have some exceptional features, which hold the promise of developing into the nextgeneration diagnostic platforms. One of these features is the ability to trigger non-specific single-stranded DNA/RNA cleavage activity after specific target recognition and Cas enzyme activation. This cleavage activity...
article 2022
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Karakitsios, S. (author), Maggos, T. (author), Busker, R.W. (author), Armand, P. (author), Bartzis, J.G. (author)
The overarching objective of the ERNCIP “Detection of Indoor Airborne Chemical & Biological Agents” Thematic Group (TG) is to strengthen resilience of critical infrastructure against airborne CB threats by improvement of detection capabilities. The subsidiary aim of the research described in this technical report is to develop knowledge on the...
report 2022
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Durán Jiménez, D. (author), de Bruin-Hoegee, J.M. (author), Alkema, D.P.W. (author), Noort, D. (author), Busker, R.W. (author), van Wuijckhuijse, A.L. (author)
conference paper 2022
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Noort, D. (author), Fidder, A. (author), van der Riet-van Oeveren, D. (author), Busker, R.W. (author), van der Schans, M.J. (author)
Novichok (NV) nerve agents were recently added to the list of Schedule 1 chemicals of the Chemical Weapons Convention. There is a well-accepted method for assessment of nerve agent exposure based on mass spectrometric analysis of a nonapeptide with the serine-198 residue modified by the nerve agent, but this approach has not yet been reported...
article 2021
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Bogers, J.F.M. (author), Berghuis, N.F. (author), Busker, R.W. (author), van Booma, A. (author), Paauw, A. (author), van Leeuwen, H.C. (author)
Fluorescence-based diagnostic tools are attractive and versatile tests with multiple advantages: ease of use, sensitivity and rapid results. The advent of CRISPR-Cas technology has created new avenues for the development of diagnostic testing tools. In this study, by effectively combining the specific functions of two enzymes, CRISPR-Cas12a and...
article 2021
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Karakitsios, S. (author), Busker, R.W. (author), Tjärnhage, T. (author), Armand, P. (author), Dybwad, M. (author), Nielseng, M.F. (author), Burmand, J. (author), Burkeh, J. (author), Brineki, J. (author), Bartzisj, J. (author), Maggosk, Th. (author), Theocharidoul, M. (author), Gattinesim, P. (author), Giannopoulos, G. (author), Sarigiannisa, D. (author)
Potential chemical and biological (CB) attacks in indoor spaces pose specific challenges for prevention and preparedness. This paper summarises the conclusions obtained from the work conducted in the framework of the ERNCIP1. A thorough review of the existing and emerging technologies for CB detection, coupled with simulations of CB airborne...
article 2020
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van der Schans, M.J. (author), van der Meer, J.A. (author), Olivier, R.C.M. (author), Busker, R.W. (author), Voorsluijs, G.M. (author), de Jong, A.J. (author)
The awareness of the possible presence of toxic chemical compounds at and around military compounds and other critical infra structures is crucial and normally monitored by point detectors. The disadvantage of these type of detectors is that large quantities (organized in a network) are needed when a large area is to be controlled. Secondly...
conference paper 2016
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Busker, R.W. (author)
Fortunately, the CBRN threat is only a minor segment of the spectrum of challenges that Defense and Security organizations have to be prepared for. Although not neglected, CBRN is not high on political agendas. This means that maintaining adequate CBRN defense, as well as the research needed to enable it, acquire only relatively moderate...
conference paper 2016
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Busker, R.W. (author), Foppen, H.M. (author)
conference paper 2014
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Busker, R.W. (author), van Wuijckhuijse, A.L. (author), Foppen, H.M. (author)
conference paper 2013
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Busker, R.W. (author), van Wuijckhuijse, A.L. (author), Foppen, M. (author)
conference paper 2012
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Busker, R.W. (author)
conference paper 2012
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Busker, R.W. (author)
conference paper 2012
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Busker, R.W. (author)
conference paper 2011
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Busker, R.W. (author)
conference paper 2011
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Busker, R.W. (author), Simonart, T. (author)
This first 1.5 day EU workshop on CBRN Research organized by the EC (DG ENTR) was well attended with 124 participants from 21 countries including many representatives from end user organizations. Major outcomes: first of all, in session 1 on EU institutional stakeholders, the high added value of continuous information sharing and cooperation...
report 2011
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Busker, R.W. (author), Green, T. (author), TNO Defensie en Veiligheid (author)
Late 2007 the European Commission launched an initiative to formulate a long-term vision on security challenges the EU is faced with. Thus, the European Security Research and Innovation Forum (ESRIF) was tasked to map out a security research and innovation agenda, to address: • Mid-term and long-term security perspectives (up to 20 years) •...
conference paper 2010
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Busker, R.W. (author)
conference paper 2010
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TNO Defensie en Veiligheid (author), van Wuijckhuijse, A.L. (author), Kientz, C.E. (author), van Baar, B.L.M. (author), Kievit, O. (author), Busker, R.W. (author), Stowers, M.A. (author), Kleefsman, I. (author), Marijnissen, J.C.M. (author)
Although banned by the BTWC in 1972, biological warfare agents continue to be a threat to military and public health. Countermeasures can only be effective if rapid detection and reliable identification techniques are in place. TNO Prins Maurits Laboratory, and Delft University of Technology and Bruker-Daltonik (Germany) are developing an...
conference paper 2005
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Kievit, O. (author), Busker, R.W. (author), Kientz, C.E. (author), Marijnissen, J.C.M. (author)
This paper describes the latest achievements in the development of a new rapid detector for biological warfare agents (BWA). The system uses aerodynamic particle sizing and matrix-assisted laser desorption/ionisation aerosol time-of-flight mass spectrometry (MALDI ATOFMS) to analyse individual aerosol particles sampled directly from the...
article 2003
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