Fibrinolysis and inflammation

The acute-phase reaction of the fibrinolytic system in acute myocardial infarction and unstable angina

A specific allele of the histidine-rich glycoprotein (HRG) locus is linked with elevated plasma levels of HRG in a Dutch family with thrombosis

Recent studies describe families with both elevated plasma HRG levels and thrombosis. In order to study the possibility that allelic variants of the HRG locus are associated with differences in HRG level, we studied linkage between HRG levels and a dinucleotide repeat polymorphism in a Dutch family which was selected on the presence of both...

The fibrinolytic system in the hemolytic uremic syndrome: In vivo and in vitro studies

Fibrinolytic parameters and von Willebrand factor (vWF) antigen were measured in the plasma of 10 patients with hemolytic uremic syndrome (HUS). Samples were taken at presentation and again 2 wk later, before and after infusion of 1-desamino-8-arginine vasopressin. Compared with the plasma values of healthy control children, levels of tissue...

Composition and susceptibility to thrombolysis of human arterial thrombi and the influence of their age

Each of three distinct, concentric layers of human arterial thrombi, was analysed immunochemically for the plasminogen and fibrin content, and for the ex vivo susceptibility to thrombolysis by various thrombolytic agents in a saline or plasma milieu. The age of the thrombus layer determined: (a) the plasminogen content; (b) the fibrin content,...

Composition and susceptibility to thrombolysis of pathological human arterial thrombi

Chemicals/CAS: Plasminogen, 9001-91-6; Streptokinase, EC 3.4.-.

Elevated plasminogen activator inhibitor (PAI), a cause of thrombophilia? A study in 203 patients with familial or sporadic venous thrombophilia

Two hundred and three patients with venous thrombophilia were investigated in order to find out whether an elevated plasma concentration of plasminogen activator inhibitor (PAI) could be a cause of their tendency to thrombosis. The patients were studied in an asymptomatic period about 3 months after their last thromboembolic episode. PAI...

Thrombolytica, nieuwe ontwikkelingen

Renal and hepatic handling of endogenous tissue-type plasminogen activator (t-PA) and its inhibitor in man

In eight male patients with normal liver and kidney function fibrinolytic components were measured in arterial blood and in renal and hepatic vein blood, obtained during catheterization for analysis of hypertension. Blood samples were collected simultaneously from veins und corresponding arteries before and 5 minutes after the completion of...

Clinical relevance of t-PA levels and of fibrinolytic assays

Thrombophilia: Its causes and a rough estimate of its prevalence

Abstract.

Hemostasis and fibrinolysis in severe liver failure and their relation to hemorrhage

In a study of severe, decompensated liver failure, we tried to find a correlation between hemorrhage and parameters of hemostasis and fibrinolysis. Three groups of patients were studied: alcoholic cirrhosis; nonalcoholic cirrhosis, and acute liver failure without known prior liver disease. The two cirrhotic groups did not differ significantly...

Onderzoek naar de oorzaken van veneuze trombose en longembolie

Bepaling van afbraakprodukten van fibrine en fibrinogeen in plasma met een monoklonaal antilichaam

Abstract.

Achtergronden van fibrinolytische therapie

A familial hemorrhagic diathesis in a Dutch family: An inherited deficiency of ??2-antiplasmin

This study concerns a case of congenital homozygous deficiency in ??2-antiplasmin associated with a severe hemorrhagic diathesis. Heterozygous family members also show a mild bleeding tendency. The propositus is a 17-yr-old male born of white parents and showing a severe hemorrhagic diathesis characterized by spontaneous bleeding in the joints...

Response of fibrinolytic activity and factor VIII-related antigen to stimulation with desmopressin in hyperlipoproteinemia

Impairment of fibrinolysis is supposed to contribute to CVD. In 38 hyperlipoproteinemic patients, known to be at risk for early CVD, fibrinolytic activity was measured before and after stimulation with DDAVP. A negative correlation was found between serum triglyceride levels and fibrinolytic activity, both before and after DDAVP. A subnormal...

Progress in fibrinolysis