document

Value of serum cartilage oligomeric matrix protein as a prognostic marker of large-joint damage in rheumatoid arthritis—data from the RAPIT study: Concise Report

de Jong, Z. (author), Munneke, M. (author), Vilim, V. (author), Zwinderman, A.H. (author), Kroon, H.M. (author), Ronday, H.K. (author), Lems, W.F. (author), Dijkmans, B.A.C. (author), Breedveld, F.C. (author), Vliet Vlieland, T.P.M. (author), Hazes, J.M.W. (author), de Groot, J. (author), TNO Kwaliteit van Leven (author)

Objective. To investigate the utility of serum COMP level measurements as a predictor of future damage of the weight-bearing (large) joints in RA patients participating in intensive exercise. Methods. Data of the 281 completers of a 2-yr randomized controlled trial (Rheumatoid Arthritis Patients In Training; RAPIT) comparing the effects of usual...

article 2008

document

Cartilage degradation and invasion by rheumatoid synovial fibroblasts is inhibited by gene transfer of TIMP-1 and TIMP-3

van der Laan, W.H. (author), Quax, P.H.A. (author), Seemayer, C.A. (author), Huisman, L.G.M. (author), Pieterman, E.J. (author), Grimbergen, J.M. (author), Verheijen, J.H. (author), Breedveld, F.C. (author), Gay, R.E. (author), Gay, S. (author), Huizinga, T.W.J. (author), Pap, T. (author), Gaubius Instituut TNO (author)

Matrix metalloproteinases (MMPs) are believed to be pivotal enzymes in the invasion of articular cartilage by synovial tissue in rheumatoid arthritis (RA). Here, we investigated the effects of gene transfer of tissue inhibitors of metalloproteinases (TIMPs) on the invasiveness of RA synovial fibroblasts (RASF) in vitro and in vivo. Adenoviral...

article 2003

document

Matrix metalloproteinases-3, -8, -9 as markers of disease activity and joint damage progression in early rheumatoid arthritis

TNO Preventie en Gezondheid (author), Tchetverikov, I. (author), Lard, L.R. (author), de Groot, J. (author), Verzijl, N. (author), TeKoppele, J.M. (author), Breedveld, F.C. (author), Huizinga, T.W.J. (author), Hanemaaijer, R. (author)

Objective: To analyse the relation between systemic levels of pro-MMP-3, -8, and -9 matrix metalloproteinase (MMP) activity in α2 macroglobulin (α2M)/MMP complexes and the progression of joint destruction in patients with recent onset rheumatoid arthritis (RA). Methods: 109 patients with RA of recent onset were entered into this longitudinal...

article 2003

document

Invasive properties of fibroblast-like synoviocytes Correlation with growth characteristics and expression of MMP-1 MMP-3 and MMP-10

TNO Preventie en Gezondheid (author), Tolboom, T.C.A. (author), Pieterman, E. (author), van der Laan, W.H. (author), Toes, R.E.M. (author), Huidekoper, A.L. (author), Nelissen, R.G.H.H. (author), Breedveld, F.C. (author), Huizinga, T.W.J. (author)

Background: Matrix metalloproteinases (MMPs) have a pivotal role in the destruction of cartilage in rheumatoid arthritis (RA), which is mediated by the fibroblast-like synoviocytes (FLS). Objective: To examine the in vitro invasiveness of synoviocytes obtained from inflamed joints of patients with arthritis in relation to the expression of MMP 1...

article 2002

document

Human granzyme B mediates cartilage proteoglycan degradation and is expressed at the invasive front of the synovium in rheumatoid arthritis

Ronday, H.K. (author), van der Laan, W.H. (author), Tak, P.P. (author), de Roos, J.A.D.M. (author), Bank, R.A. (author), Tekoppele, J.M. (author), Froelich, C.J. (author), Hack, C.E. (author), Hogendoorn, P.C.W. (author), Breedveld, F.C. (author), Verheijen, J.H. (author), Gaubius Instituut (author)

Objective. To investigate the cartilage-degrading capacity of granzyme B and the presence of granzyme B-positive cells at sites of erosion in the rheumatoid synovium. Methods. Granzyme B was added to [3H]proline/[35S]sulphate-labelled cartilage matrices and to cartilage explants. Proteoglycan degradation was assessed by the release of 35S and...

article 2001

document

Cartilage invasion by rheumatoid synovial fibroblasts in vivo is inhibited by gene transfer of a cell surface-targeted plasmin inhibitor: Abstract

van der Laan, W.H. (author), Ronday, H.K. (author), Grimbergen, J.M. (author), Huisman, L.G.M. (author), TeKoppele, J.M. (author), Breedveld, F.C. (author), Gay, R.E. (author), Gay, S. (author), Huizinga, T.W.J. (author), Verheijen, J.H. (author), Quax, P.H.A. (author), Pap, T. (author), Gaubius Instituut TNO (author)

article 2000

document

Cartilage degradation and invasion by rheumatoid synovial fibroblasts is inhibited by gene transfer of a cell surface-targeted plasmin inhibitor

van der Laan, W.H. (author), Pap, T. (author), Ronday, H.K. (author), Grimbergen, J.M. (author), Huisman, L.G.M. (author), TeKoppele, J.M. (author), Breedveld, F.C. (author), Gay, R.E. (author), Gay, S. (author), Huizinga, T.W.J. (author), Verheijen, J.H. (author), Quax, P.H.A. (author)

article 2000

document

Lack of effect of doxyxyxline on disease activity and pyridinoline excretion rates in rheumatoid arthritis: a double-blind placebo-controlled study: abstract

Gaubius Instituut TNO (author), van der Laan, W.H. (author), Molenaar, E.T. (author), Verheijen, J.H. (author), Breedveld, F.C. (author), Dijkmans, B.A.C. (author), te Koppele, J.M. (author)

article 2000

document

Afbraak van kraakbeenmatrix door rheumatoïde synoviocyten wordt geremd door een membraan gebonden plasmine remmer via gentherapie

van der Laan, W.H. (author), Ronday, H.K. (author), Grimbergen, J.M. (author), Huisman, L.G.M. (author), TeKoppele, J.M. (author), Huizinga, T.W.J. (author), Breedveld, F.C. (author), Verheijen, J.H. (author), Quax, P.H.A. (author), Gaubius Instituut TNO (author)

bookPart 1999

document

Degradation of a cartilage-like matrix by rheumatoid synovial fibroblasts is inhibited by gene transfer with a cell surface-targeted plasmin inhibitor: abstract

Gaubius Instituut TNO (author), van der Laan, W.H. (author), Ronday, H.K. (author), Grimbergen, J.M. (author), Huisman, L.G.M. (author), Breedveld, F.C. (author), te Koppele, J.M. (author), Huizinga, T.W.J. (author), Quax, P.H.A. (author), Verheijen, J.H. (author)

article 1999

document

Tranexamic acid, an inhibitor of plasminogen activation, reduces urinary collagen cross-link excretion in both experimental and rheumatoid arthritis

Ronday, H.K. (author), TeKoppele, J.M. (author), Greenwald, R.A. (author), Moak, S.A. (author), de Roos, J.A.D.M. (author), Dijkmans, B.A.C. (author), Breedveld, F.C. (author), Verheijen, J.H. (author), Gaubius Instituut TNO (author)

The plasminogen activation system is one of the enzyme systems held responsible for bone and cartilage degradation in rheumatoid arthritis (RA). In this study, we evaluated the effect of tranexamic acid (TEA), an inhibitor of plasminogen activation, on urinary collagen cross-link excretion and radiological joint damage in rat adjuvant arthritis ...

article 1998

document

A genetic association study of the IGF-1 gene and radiological osteoarthritis in a population-based cohort study (the Rotterdam study)

Gaubius Instituut TNO (author), Meulenbelt, I. (author), Bijkerk, C. (author), Miedema, H.S. (author), Breedveld, F.C. (author), Hofman, A. (author), Valkenburg, H.A. (author), Pols, H.A.P. (author), Slagboom, P.E. (author), van Duijn, C.M. (author)

Objective - A genetic association study was performed to investigate whether radiographical osteoarthritis (ROA) was associated with specific genotypes of the insulin-like growth factor I (IGF-1) gene. Methods - Subjects aged 55-65 years were selected from a population-based study of which ROA at the knee, hip, spine, and hand was assessed....

article 1998

document

Investigation of the association of the CRTM and CRTL1 genes with radiographically evident osteoarthritis in subjects from the Rotterdam study

Meulenbelt, I. (author), Bijkerk, C. (author), de Wildt, S.C.M. (author), Miedema, H.S. (author), Valkenburg, H.A. (author), Breedveld, F.C. (author), Pols, H.A.P. (author), TeKoppele, J.M. (author), Sloos, V.F.G. (author), Hofman, A. (author), Slagboom, P.E. (author), van Duijn, C.M. (author)

Objective. To investigate whether radiographically evident osteoarthritis (ROA) in 55-65-year-old men and women is associated with specific alleles or genotypes of the cartilage matrix protein (CRTM) and cartilage link protein (CRTL1) genes. Methods. Cases were selected from a population-based study on the presence of ROA of the knee or hip....

article 1997

document

Increased expression of interferon (IFN)-gamma together with IFN-gamma receptor in the rheumatoid synovial membrane compared with synovium of patients with osteoarthritis

Dolhain, R.J.E.M. (author), ter Haar, N.T. (author), Hoefakker, S. (author), Tak, P.P. (author), de Ley, M. (author), Claassen, E. (author), Breedveld, F.C. (author), Miltenburg, A.M.M. (author), TNO Preventie en Gezondheid (author)

Data concerning the presence of T-cell-derived cytokines in the rheumatic joint are conflicting, challenging the hypothesis that rheumatoid arthritis (RA) is a T-cell-mediated disease. In this study synovial tissue specimens of 11 patients with RA and eight patients with osteoarthritis (OA) were stained for interferon-gamma IFN-γ) and its...

article 1996

document

The plasminogen activation system in rheumatoid arthritis

Ronday, H.K. (author), Breedveld, F.C. (author), Verheijen, J.H. (author), Gaubius Instituut TNO (author)

article 1996

document

Difference in expression of the plasminogen activation system in synovial tissue of patients with rheumatoid arthritis and osteoarthritis

Ronday, H.K. (author), Smits, H.H. (author), van Muijen, G.N.P. (author), Pruszczynski, M.S.M. (author), Dolhain, R.J.E.M. (author), van Langelaan, E.J. (author), Breedveld, F.C. (author), Verheijen, J.H. (author), Gaubius Instituut TNO (author)

Proteolytic joint destruction in inflammatory and non-inflammatory arthropathy is believed to be mediated, at least in part, by the plasminogen activation (PA) system. To further investigate possible involvement of the PA system, we quantified immunoreactive urokinase-type plasminogen activator (u-PA), tissue-type plasminogen activator (t-PA),...

article 1996

document

Direct assessment of junctional diversity in rearranged T cell receptor β chain encoding genes by combined heteroduplex and single strand conformation polymorphism (SSCP) analysis

Offermans, M.T.C. (author), Struyk, L. (author), de Geus, B. (author), Breedveld, F.C. (author), van den Elsen, P.J. (author), Rozing, J. (author), TNO Preventie en Gezondheid (author)

In order to define the extent of T cell heterogeneity and clonality, unique DNA sequences in the junctional region in rearranged T cell receptor (TcR) genes can be studied. For this purpose we have adapted a non-denaturing nucleic acid gel electrophoresis procedure to detect TcR junctional diversity. Detection of junctional diversity is based...

article 1996

document

The role of genetic factors in the etiology of osteoarthritis;

Slagboom, P.E. (author), Breedveld, F.C. (author), Meulenbelt, I. (author), Gaubius Instituut TNO (author)

Osteoarthritis (OA) ls characterized by degeneration ol the articular cartilage and formation of new bone. Little is known about the etiology of this multifactorial disease. The most ¡mportant r¡sk factors are age, trauma, obesity, metabolic disturbances, anatomical abnormal¡ties and genetic predisposition. The role of genetic factors in the...

conference paper 1995

document

Urokinase mediated, plasmin degradation of bone-like matrix

Ronday, H.K. (author), Smits, H.H. (author), Quax, P.H.A. (author), van der Pluijm, G. (author), Löwik, C.W.G.M. (author), Breedveld, F.C. (author), Verheijen, J.H. (author), Gaubius Instituut TNO (author)

article 1995