Searched for: author%3A%22Bouwman%2C+J.%22
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Bayle, M.L. (author), Wopereis, S. (author), Bouwman, J. (author), van Ommen, B. (author), Scalbert, A. (author), Pujos-Guillot, E. (author)
Recommended dietary allowances for micronutrients fluctuate noticeably within European Union countries. The Network of Excellence EURRECA (EURopean micronutrient RECommendations Aligned) aims at harmonising micronutrient intake recommendations through population groups. The lack of proper markers of status for some micronutrients limits progress...
article 2012
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Szymańska, E. (author), Bouwman, J. (author), Strassburg, K. (author), Vervoort, J. (author), Kangas, A.J. (author), Soininen, P. (author), Ala-Korpela, M. (author), Westerhuis, J. (author), van Duynhoven, J.P.M. (author), Mela, D.J. (author), MacDonald, I.A. (author), Vreeken, R.J. (author), Smilde, A.K. (author), Jacobs, D.M. (author)
Obesity is a risk factor for cardiovascular diseases and type 2 diabetes especially when the fat is accumulated to central depots. Novel biomarkers are crucial to develop diagnostics for obesity and related metabolic disorders. We evaluated the associations between metabolite profiles (136 lipid components, 12 lipoprotein subclasses, 17 low...
article 2012
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Wei, H. (author), Hu, C. (author), Wang, M. (author), van den Hoek, A.M. (author), Reijmers, T.H. (author), Wopereis, S. (author), Bouwman, J. (author), Ramaker, R. (author), Korthout, H.A.A.J. (author), Vennik, M. (author), Hankemeier, T. (author), Havekes, L.M. (author), Witkamp, R.F. (author), Verheij, E.R. (author), Xu, G. (author), van der Greef, J. (author)
Background: Causes and consequences of the complex changes in lipids occurring in the metabolic syndrome are only partly understood. Several interconnected processes are deteriorating, which implies that multi-target approaches might be more successful than strategies based on a limited number of surrogate markers. Preparations from Chinese...
article 2012
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Bouwman, J. (author), Vogels, J.T.W.E. (author), Wopereis, S. (author), Rubingh, C.M. (author), Bijlsma, S. (author), van Ommen, B. (author)
Background: Being able to visualize multivariate biological treatment effects can be insightful. However the axes in visualizations are often solely defined by variation and thus have no biological meaning. This makes the effects of treatment difficult to interpret. Methods: A statistical visualization method is presented, which analyses and...
article 2012
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van Eunen, K. (author), Rossell, S. (author), Bouwman, J. (author), Westerhoff, H.V. (author), Bakker, B.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Regulation analysis is a methodology that quantifies to what extent a change in the flux through a metabolic pathway is regulated by either gene expression or metabolism. Two extensions to regulation analysis were developed over the past years: (i) the regulation of Vmax can be dissected into the various levels of the gene-expression cascade,...
conference paper 2011
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Hu, C. (author), Wei, H. (author), Kong, H. (author), Bouwman, J. (author), Gonzalez-Covarrubias, V. (author), van der Heijden, R. (author), Reijmers, T.H. (author), Bao, X. (author), Verheij, E.R. (author), Hankemeier, T. (author), Xu, G. (author), van der Greef, J. (author), Wang, M. (author)
Although a number of animal experiments and clinical trials have investigated the effects of ginseng roots on diabetes, the relationship between their therapeutic effects on diabetes and the quality and the growth age of this herb have not yet been reported. This study systematically investigated the effects of 3- to 6-year-old ginseng roots on...
article 2011
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Bouwman, J. (author), Kiewiet, J. (author), Lindenbergh, A. (author), van Eunen, K. (author), Siderius, M. (author), Bakker, B.M. (author)
Intracellular accumulation of glycerol is essential for yeast cells to survive hyperosmotic stress. Upon hyperosmotic stress the gene expression of enzymes in the glycerol pathway is strongly induced. Recently, however, it was shown that this gene-expression response is not essential for survival of an osmotic shock [Mettetal JT et al. (2008)...
article 2011
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Hu, C. (author), Wei, H. (author), van den Hoek, A.M. (author), Wang, M. (author), van der Heijden, R. (author), Spijksma, G. (author), Reijmers, T.H. (author), Bouwman, J. (author), Wopereis, S. (author), Havekes, L.M. (author), Verheij, E. (author), Hankemeier, T. (author), Xu, G. (author), van der Greef, J. (author)
Background: Lipids are known to play crucial roles in the development of life-style related risk factors such as obesity, dyslipoproteinemia, hypertension and diabetes. The first selective cannabinoid-1 receptor blocker rimonabant, an anorectic anti-obesity drug, was frequently used in conjunction with diet and exercise for patients with a body...
article 2011
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Haanstra, J.R. (author), Kerkhoven, E.J. (author), van Tuijl, A. (author), Blits, M. (author), Wurst, M. (author), van Nuland, R. (author), Albert, M-A. (author), Michels, P.A. (author), Bouwman, J. (author), Clayton, C. (author), Westerhoff, H.V. (author), Bakker, B.M. (author)
Awareness is growing that drug target validation should involve systems analysis of cellular networks. There is less appreciation, though, that the composition of networks may change in response to drugs. If the response is homeostatic (e.g. through upregulation of the target protein), this may neutralize the inhibitory effect. In this scenario...
article 2011
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van Eunen, K. (author), Dool, P. (author), Canelas, AB. (author), Kiewiet, J. (author), Bouwman, J. (author), van Gulik, W.M. (author), Westerhoff, H.V. (author), Bakker, B.M. (author)
In this study, the authors investigated how the glycolytic flux was regulated in time upon nitrogen starvation of cells with different growth histories. We have compared cells grown in glucose-limited chemostat cultures under respiratory conditions (low dilution rate of 0.1/h) to cells grown under respirofermentative conditions (high dilution...
article 2010
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Canelas, A.B. (author), Harrison, N. (author), Fazio, A. (author), Zhang, J. (author), Pitkänen, J.P. (author), van den Brink, J. (author), Bakker, B.M. (author), Bogner, L. (author), Bouwman, J. (author), Castrillo, J.I. (author), Cankorur, A. (author), Chumnanpuen, P. (author), Daran-Lapujade, P. (author), Dikicioglu, D. (author), van Eunen, K. (author), Ewald, J.C. (author), Heijnen, J.J. (author), Kirdar, B. (author), Mattila, I. (author), Mensonides, F.I. (author), Niebel, A. (author), Penttilä, M. (author), Pronk, J.T. (author), Reuss, M. (author), Salusjärvi, L. (author), Sauer, U. (author), Sherman, D. (author), Siemann-Herzberg, M. (author), Westerhoff, H. (author), de Winde, J. (author), Petranovic, D. (author), Oliver, S.G. (author), Workman, C.T. (author), Zamboni, N. (author), Nielsen, J. (author)
The field of systems biology is often held back by difficulties in obtaining comprehensive, high-quality, quantitative data sets. In this paper, we undertook an interlaboratory effort to generate such a data set for a very large number of cellular components in the yeast Saccharomyces cerevisiae, a widely used model organism that is also used in...
article 2010
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TNO Kwaliteit van Leven (author), van Eunen, K., (author), Bouwman, J. (author), Daran-Lapujade, P. (author), Postmus, J. (author), Canelas, A.B. (author), Mensonides, F.I. (author), I. Orij R, Tuzun, (author), van den Brink, J., (author), Smits, G.J. (author), van Gulik, W.M. (author), Brul, S. (author), Heijnen, J.J. (author), de Winde, J.H. (author), de Mattos, M.J. (author), Kettner, C. (author), Nielsen, J. (author), Westerhoff, H.V. (author), Bakker, B.M. (author)
article 2010
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TNO Kwaliteit van Leven (author), van Ommen, B. (author), Bouwman, J. (author), Dragsted, L.O. (author), Drevon, C.A. (author), Elliott, R. (author), de Groot, P. (author), Kaput, J. (author), Mathers, J.C. (author), Müller, M. (author), Pepping, F. (author), Saito, J. (author), Scalbert, A. (author), Radonjic, M. (author), Rocca-Serra, P. (author), Travis, A. (author), Wopereis, S. (author), Evelo, C.T. (author)
The challenge of modern nutrition and health research is to identify food-based strategies promoting life-long optimal health and well-being. This research is complex because it exploits a multitude of bioactive compounds acting on an extensive network of interacting processes. Whereas nutrition research can profit enormously from the revolution...
article 2010
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TNO Kwaliteit van Leven (author), van Ommen, B. (author), El-Sohemy, A. (author), Hesketh, J. (author), Kaput, J. (author), Fenech, M. (author), Evelo, C.T. (author), McArdle, H.J. (author), Bouwman, J. (author), Lietz, G. (author), Mathers, J.C. (author), Fairweather-Tait, S. (author), van Kranen, H. (author), Elliott, R. (author), Wopereis, S. (author), Ferguson, L.R. (author), Méplan, C. (author), Perozzi, G. (author), Allen, L. (author), Rivero, D. (author)
Micronutrients influence multiple metabolic pathways including oxidative and inflammatory processes. Optimum micronutrient supply is important for the maintenance of homeostasis in metabolism and, ultimately, for maintaining good health. With advances in systems biology and genomics technologies, it is becoming feasible to assess the activity of...
article 2010
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van Eunen, K. (author), Dool, P. (author), Canelas, A.B. (author), Kiewiet, J. (author), Bouwman, J. (author), van Gulik, W.M. (author), Westerhoff, H.V. (author), Bakker, B.M. (author), TNO Kwaliteit van Leven (author)
In this study, the authors investigated how the glycolytic flux was regulated in time upon nitrogen starvation of cells with different growth histories. We have compared cells grown in glucose-limited chemostat cultures under respiratory conditions (low dilution rate of 0.1/h) to cells grown under respirofermentative conditions (high dilution...
article 2009
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Tas, A.C. (author), van der Greef, J. (author), de Waart, J. (author), Bouwman, J. (author), de Noever ten-Brauw, M.C. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Pyrograms of Serratia and Pseudomonas have been measured with direct chemical ionization (DCI) and direct-probe electron impact and chemical ionization. Using pattern recognition, it was found that DCI yields pyrograms with the highest specificity. Furthermore, DCI pyrolysis was found to be more sensitive than the other two methods and also...
article 1985
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van der Greef, J. (author), Bouwman, J. (author), Odink, J. (author), Schrijver, J. (author), ten Noever de Brouw, M.C. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
It is shown that a fast evaluation of field desorption mass spectrometric profiles can be obtained, using quotient spectra and calculation of quotient weight factors. The characteristics of a program developed for this purpose are described and as an example this approach has been applied to detect metabolites in urine samples
article 1984
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van der Greef, J. (author), Tas, A.C. (author), Bouwman, J. (author), ten Noever de Brauw, M.C. (author), Schreurs, W.H.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Field-desorption and fast atom-bombardment mass spectrometry are promising techniques for generating profiles of complex mixture of non-volatile compounds. This was concluded from results obtained with urine and wine samples. Pattern recognition techniques, such as non-linear mapping, K-nearest neighbours and principal component analysis, in...
article 1983
Searched for: author%3A%22Bouwman%2C+J.%22
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