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Najjar, A. (author), Punt, A. (author), Wambaugh, J. (author), Paini, A. (author), Ellison, C. (author), Fragki, S. (author), Bianchi, E. (author), Zhang, F. (author), Westerhout, J. (author), Mueller, D. (author), Li, H. (author), Shi, Q. (author), Gant, T.W. (author), Botham, P. (author), Bars, R. (author), Piersma, A. (author), van Ravenzwaay, B. (author), Kramer, N.I. (author)
With an increasing need to incorporate new approach methodologies (NAMs) in chemical risk assessment and the concomitant need to phase out animal testing, the interpretation of in vitro assay readouts for quantitative hazard characterisation becomes more important. Physiologically based kinetic (PBK) models, which simulate the fate of chemicals...
article 2022
Heusinkveld, H. (author), Braakhuis, H. (author), Gommans, R. (author), Botham, P. (author), Corvaro, M. (author), van der Laan, J.W. (author), Lewis, D. (author), Madia, F. (author), Manou, I. (author), Schorsch, F. (author), Wolterink, G. (author), Woutersen, R. (author), Corvi, R. (author), Mehta, J. (author), Luijten, M. (author)
Chemical substances are subjected to assessment of genotoxic and carcinogenic effects before being marketed to protect man and the environment from health risks. For agrochemicals, the long-term rodent carcinogenicity study is currently required from a regulatory perspective. Although it is the current mainstay for the detection of nongenotoxic...
article 2020