Searched for: author%3A%22Boomsma%2C+D.I.%22
(1 - 20 of 27)

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Draisma, H.H. (author), Reijmers, T.H. (author), Meulman, J.J. (author), van der Greef, J. (author), Hankemeier, T. (author), Boomsma, D.I. (author)
Twin and family studies are typically used to elucidate the relative contribution of genetic and environmental variation to phenotypic variation. Here, we apply a quantitative genetic method based on hierarchical clustering, to blood plasma lipidomics data obtained in a healthy cohort consisting of 37 monozygotic and 28 dizygotic twin pairs, and...
article 2013
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Vink, J.M. (author), Boomsma, D.I. (author), Medland, S.E. (author), de Moor, H.M. (author), Stubbe, J.H. (author), Corner, B.K. (author), Martin, N.G. (author), Skytthea, A. (author), Kyvik, K.O. (author), Rose, R.J. (author), Kujala, U.M. (author), Kaprio, J. (author), Harris, J.R. (author), Pedersen, N.L. (author), Cherkas, L. (author), Spector, T.D. (author), Geus, E.J. (author)
Physical activity is influenced by genetic factors whose expression may change with age. We employed an extension to the classical twin model that allows a modifier variable, age, to interact with the effects of the latent genetic and environmental factors. The model was applied to self-reported data from twins aged 19 to 50 from seven countries...
article 2011
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Draisma, H.H.M. (author), Reijmers, T.H. (author), van Kloet, F.D. (author), Bobeldijk-Pastorova, I. (author), Spies-Faber, E. (author), Vogels, J.T.W.E. (author), Meulman, J.J. (author), Boomsma, D.I. (author), van Greef, J.D. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)
Combination of data sets from different objects (for example, from two groups of healthy volunteers from the same population) that were measured on a common set of variables (for example, metabolites or peptides) is desirable for statistical analysis in "omics" studies because it increases power. However, this type of combination is not directly...
article 2010
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Willemsen, G. (author), de Geus, E.J.C. (author), Bartels, M. (author), van Beijsterveldt, C.E.M.T. (author), Brooks, A.I. (author), Estourgie-van Burk, G.F. (author), Fugman, D.A. (author), Hoekstra, C. (author), Hottenga, J.-J. (author), Kluft, K. (author), Meijer, P. (author), Montgomery, G.W. (author), Rizzu, P. (author), Sondervan, D. (author), Smit, A.B. (author), Spijker, S. (author), Suchiman, H.E.D. (author), Tischfield, J.A. (author), Lehner, T. (author), Slagboom, P.E. (author), Boomsma, D.I. (author), TNO Kwaliteit van Leven (author)
In 2004 the Netherlands Twin Register (NTR) started a large scale biological sample collection in twin families to create a resource for genetic studies on health, lifestyle and personality. Between January 2004 and July 2008, adult participants from NTR research projects were invited into the study. During a home visit between 7:00 and 10:00 am...
article 2010
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Boomsma, D.I. (author), Willemsen, G. (author), Sullivan, P.F. (author), Heutink, P. (author), Meijer, P. (author), Sondervan, D. (author), Kluft, C. (author), Smit, G. (author), Nolen, W.A. (author), Zitman, F.G. (author), Smit, J.H. (author), Hoogendijk, W.J. (author), van Dyck, R. (author), de Geus, E.J.C. (author), Penninx, B.W.J.H. (author), TNO Kwaliteit van Leven (author)
To identify the genomic regions that confer risk and protection for major depressive disorder (MDD) in humans, large-scale studies are needed. Such studies should collect multiple phenotypes, DNA, and ideally, biological material that allows gene expression analysis, transcriptomic, proteomic, and metabolomic studies. In this paper, we briefly...
article 2008
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TNO Kwaliteit van Leven (author), Draisma, H.H.M. (author), Reijmers, T.H. (author), Bobeldijk-Pastorova, I. (author), Meulman, J.J. (author), van Estourgie-Burk, G.F. (author), Bartels, M. (author), Ramaker, R. (author), van der Greef, J. (author), Boomsma, D.I. (author), Hankemeier, T. (author)
Differences in genetic background and/or environmental exposure among individuals are expected to give rise to differences in measurable characteristics, or phenotypes. Consequently, genetic resemblance and similarities in environment should manifest as similarities in phenotypes. The metabolome reflects many of the system properties, and is...
article 2008
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de Lange, M. (author), de Geus, E.J.C. (author), Kluft, C. (author), Meijer, P. (author), van Doornen, L.J.P. (author), Boomsma, D.I. (author), Snieder, H. (author), TNO Kwaliteit van Leven (author)
Differences in genetic influence on death from CHD between males and females have been reported. Haemostatic factors have consistently been associated with risk for coronary heart disease (CHD), but sex differences in genetic architecture have not been studied. This study in middle-aged twins investigates whether there are sex differences in...
article 2006
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van Dommelen, P. (author), de Gunst, M.C.M. (author), van der Vaart, A.W. (author), van Buuren, S. (author), Boomsma, D.I. (author), TNO Preventie en Gezondheid (author)
Objective. To determine the magnitude of the growth retardation in Dutch monozygotic and dizygotic twins during infancy in comparison with the Dutch reference growth charts for general population infants from 1997 and to construct reference growth charts for twins. Design. Descriptive. Method. The growth of twins was studied using longitudinal...
article 2004
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Beekman, M. (author), Posthuma, D. (author), Heijmans, B.T. (author), Lakenberg, N. (author), Suchiman, H.E.D. (author), Snieder, H. (author), de Knijff, P. (author), Frants, R.R. (author), van Ommen, G.J.B. (author), Kluft, C. (author), Vogler, G.P. (author), Slagboom, P.E. (author), Boomsma, D.I. (author)
Combined association and linkage analysis is a powerful tool for pinpointing functional quantitative traits (QTLs) responsible for regions of significant linkage identified in genome-wide scans. We applied this technique to apoE plasma levels and the APOEε2/ε3/ε4 polymorphism in two Dutch twin cohorts of different age ranges. Across chromosome...
article 2004
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Gaubius Instituut TNO Preventie en Gezondheid (author), Hoekstra, C. (author), Meijer, P. (author), Kluft, C. (author), Heutink, P. (author), Smit, G. (author), de Geus, E. (author), Smit, J.H. (author), van Bruggen, A. (author), Montgomery, G.W. (author), Boomsma, D.I. (author)
To locate the genes that make a substantial contribution to variation in natural dizygotic twinning in humans, large-scale studies are needed. New studies should not stop at DNA genotyping, but collect material that allow gene-expression analysis, transcriptomics, proteomics and endocrinology. In this article we describe a pilot study to examine...
article 2004
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van Dommelen, P. (author), de Gunst, M.C.M. (author), van der Vaart, A.W. (author), Boomsma, D.I. (author)
Longitudinal height and weight data from 4649 Dutch twin pairs between birth and 2.5 years of age were analyzed. The data were first summarized into parameters of a polynomial of degree 4 by a mixed-effects procedure. Next, the variation and covariation in the parameters of the growth curve (size at one year of age, growth velocity, deceleration...
article 2004
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Beekman, M. (author), Heijmans, B.T. (author), Martin, N.G. (author), Whitfield, J.B. (author), Pedersen, N.L. (author), de Faire, U. (author), Snieder, H. (author), Lakenberg, N. (author), Suchiman, H.E.D. (author), de Knijff, P. (author), Frants, R.R. (author), van Ommen, G.J.B. (author), Kluft, C. (author), Vogler, G.P. (author), Boomsma, D.I. (author), Slagboom, P.E. (author)
The genetic basis of cardiovascular disease (CVD) with its complex etiology is still largely elusive. Plasma levels of lipids and apolipoproteins are among the major quantitative risk factors for CVD and are well-established intermediate traits that may be more accessible to genetic dissection than clinical CVD end points. Chromosome 19 harbors...
article 2003
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Beekman, M. (author), Heijmans, B.T. (author), Martin, N.G. (author), Whitfield, J.B. (author), Pedersen, N.L. (author), de Faire, U. (author), Snieder, H. (author), Lakenberg, N. (author), de Knijff, P. (author), Frants, R.R. (author), van Ommen, G.J.B. (author), Kluft, C. (author), Vogler, G.P. (author), Slagboom, P.E. (author), Boomsma, D.I. (author)
Plasma levels of lipoprotein(a) - Lp(a) - are associated with cardiovascular risk (Danesh et al., 2000) and were long believed to be influenced by the LPA locus on chromosome 6q27 only. However, a recent report of Broeckel et al. (2002) suggested the presence of a second quantitative trait locus on chromosome 1 influencing Lp(a) levels. Using a...
article 2003
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Gaubius Instituut TNO Preventie en Gezondheid (author), Boomsma, D.I. (author), Princen, H.M. (author), Frants, R.R. (author), Leuven, J.A.G. (author), Kempen, H.J.M. (author)
Significant familial aggregation was observed for plasma levels of lathosterol (an indicator of whole-body cholesterol synthesis) and plant sterols campesterol and β-sitosterol (indicators of cholesterol absorption) in 160 Dutch families consisting of adolescent mono- and dizygotic twin pairs and their parents. For lathosterol a moderate genetic...
article 2003
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TNO Preventie en Gezondheid (author), Boomsma, D.I. (author), Beem, A.L. (author), van den Berg, M. (author), Dolan, C.V. (author), Koopmans, J.R. (author), Vink, J.M. (author), de Geus, E.J.C. (author), Slagboom, P.E. (author)
In a longitudinal study of Dutch adolescent and young adult twins, their parents and their siblings, questionnaire data were collected on depression, anxiety and correlated personality traits, such as neuroticism. Data were collected by mailed surveys in 1991, 1993, 1995 and 1997. A total of 13 717 individuals from 3344 families were included in...
article 2000
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TNO Preventie en Gezondheid (author), Rietveld, M.J.H. (author), van der Valk, J.C. (author), Bongers, I.L. (author), Stroet, T.M. (author), Slagboom, P.E. (author), Boomsma, D.I. (author)
This study reports on zygosity determination in twins of childhood age. Parents responded to questionnaire items dealing with twin similarity in physical characteristics anti frequency of mistaking one twin for another by parents, relatives and strangers. The accuracy of zygosity diagnosis was evaluated across twins aged 6, 8, and 10 and across...
article 2000
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Gaubius Instituut TNO Preventie en Gezondheid (author), Neale, M.C. (author), de Knijff, P. (author), Havekes, L.M. (author), Boomsma, D.I. (author)
ApoE levels and chromosome 19 ApoE polymorphisms were measured in a sample of 156 Dutch families. Each pedigree consisted of parents aged 35-65 years and their twin offspring aged 14-21 years. A significant effect of the chromosome 19 apoE locus on quantitative plasma levels of apolipoprotein E was observed. The ApoE polymorphism explained 16%...
article 2000
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Hoffer, M.J.V. (author), Bredie, S.J.H. (author), Snieder, H. (author), Reymer, P.W.A. (author), Demacker, P.N.M. (author), Havekes, L.M. (author), Boomsma, D.I. (author), Stalenhoef, A.F.H. (author), Frants, R.R. (author), Kastelein, J.J.P. (author), Gaubius Instituut TNO (author)
Familial combined hyperlipidemia (FCHL) is a frequent cause of premature coronary artery disease. Affected family members are characterized by different combinations of elevated cholesterol and/or triglyceride levels. A reduction in lipoprotein lipase (LPL) activity has been observed in a subgroup of FCHL patients. Recently, we have demonstrated...
article 1998
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Vogler, G.P. (author), McClearn, G.E. (author), Snieder, H. (author), Boomsma, D.I. (author), Palmer, R. (author), de Knijff, P. (author), Slagboom, P.E. (author), TNO Preventie en Gezondheid (author)
This is the second in a series of three articles addressing the intersection of interests in behavioral genetics and behavioral medicine. In this article, we use risk factors for cardiovascular disease as a prototypical trait for which behavioral genetic approaches provide powerful tools for understanding how risk factors, behavior, and health...
article 1997
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Hoffer, M.J.V. (author), Bredie, S.J.H. (author), Boomsma, D.I. (author), Reymer, P.W.A. (author), Kastelein, J.J.P. (author), de Knijff, P. (author), Demacker, P.N.M. (author), Stalenhoef, A.F.H. (author), Havekes, L.M. (author), Frants, R.R. (author), Gaubius Instituut TNO (author)
Familial combined hyperlipidaemia (FCHL) is one of the major genetic causes of coronary heart disease (CHD) and is characterised by elevated levels of plasma cholesterol and/or triglycerides in individuals within a single family. Decreased lipoprotein lipase (LPL) activity has been found in some cases of FCHL. A recent study revealed a common...
article 1996
Searched for: author%3A%22Boomsma%2C+D.I.%22
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